Leonard Cohen Hallelujah Covers | Spotify Playlist

Almost five hours of cover versions of one of Leonard Cohen's most famous songs

I hadn’t noticed until now because of a head cold that’s taken me out of commission this weekend, but because of the passing of Leonard Cohen at the end of last week and possibly the cold open of Saturday Night Live, a growing number of people are following/using a Spotify Playlist I had made earlier this year in January.

If you need almost five hours of all the extant Hallelujah covers on Spotify to soothe your soul (for any reason), please feel free to save yourself the time of building it and enjoy my playlist. If you’re aware of any missing covers (that exist on Spotify), please let me know and I’m happy to add them to the collection.

Keep your chin up!

Leonard Cohen (), a Canadian singer, songwriter, poet and novelist
in Various Positions (Recorded June 1984; released December 1984) for Columbia Records, produced by John Lissauer

 

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Transplantation of spinal cord–derived neural stem cells for ALS

Transplantation of spinal cord–derived neural stem cells for ALS (neurology.org)
Analysis of phase 1 and 2 trials testing the safety of spinal cord transplantation of human stem cells in patients with amyotrophic lateral sclerosis (ALS) with escalating doses and expansion of the trial to multiple clinical centers.

I built the microinjectors used in these experiments for injecting stem cells into the first human patients.

CNN also has a general interest article talking about some of the results.

Links to some earlier articles:

Transplantation of spinal cord–derived neural stem cells for ALS

Analysis of phase 1 and 2 trials

Authors: Jonathan D. Glass, MD; Vicki S. Hertzberg, PhD; Nicholas M. Boulis, MD; Jonathan Riley, MD; Thais Federici, PhD; Meraida Polak, RN; Jane Bordeau, RN; Christina Fournier, MD; Karl Johe, PhD; Tom Hazel, PhD; Merit Cudkowicz, MD; Nazem Atassi, MD; Lawrence F. Borges, MD; Seward B. Rutkove, MD; Jayna Duell, RN; Parag G. Patil, MD; Stephen A. Goutman, MD; Eva L. Feldman, MD, PhD

ABSTRACT

Objective: To test the safety of spinal cord transplantation of human stem cells in patients with amyotrophic lateral sclerosis (ALS) with escalating doses and expansion of the trial to multiple clinical centers.

Methods: This open-label trial included 15 participants at 3 academic centers divided into 5 treatment groups receiving increasing doses of stem cells by increasing numbers of cells/injection and increasing numbers of injections. All participants received bilateral injections into the cervical spinal cord (C3-C5). The final group received injections into both the lumbar (L2-L4) and cervical cord through 2 separate surgical procedures. Participants were assessed for adverse events and progression of disease, as measured by the ALS Functional Rating Scale–Revised, forced vital capacity, and quantitative measures of strength. Statistical analysis focused on the slopes of decline of these phase 2 trial participants alone or in combination with the phase 1 participants (previously reported), comparing these groups to 3 separate historical control groups.

Results: Adverse events were mostly related to transient pain associated with surgery and to side effects of immunosuppressant medications. There was one incident of acute postoperative deterioration in neurologic function and another incident of a central pain syndrome. We could not discern differences in surgical outcomes between surgeons. Comparisons of the slopes of decline with the 3 separate historical control groups showed no differences in mean rates of progression.

Conclusions: Intraspinal transplantation of human spinal cord–derived neural stem cells can be safely accomplished at high doses, including successive lumbar and cervical procedures. The procedure can be expanded safely to multiple surgical centers.

Classification of evidence: This study provides Class IV evidence that for patients with ALS, spinal cord transplantation of human stem cells can be safely accomplished and does not accelerate the progression of the disease. This study lacks the precision to exclude important benefit or safety issues.

Source: Transplantation of spinal cord–derived neural stem cells for ALS

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