IPAM Workshop on Regulatory and Epigenetic Stochasticity in Development and Disease, March 1-3

IPAM Workshop on Regulatory and Epigenetic Stochasticity in Development and Disease (Institute for Pure and Applied Mathematics, UCLA | March 1-3, 2017)
Epigenetics refers to information transmitted during cell division other than the DNA sequence per se, and it is the language that distinguishes stem cells from somatic cells, one organ from another, and even identical twins from each other. In contrast to the DNA sequence, the epigenome is relatively susceptible to modification by the environment as well as stochastic perturbations over time, adding to phenotypic diversity in the population. Despite its strong ties to the environment, epigenetics has never been well reconciled to evolutionary thinking, and in fact there is now strong evidence against the transmission of so-called “epi-alleles,” i.e. epigenetic modifications that pass through the germline.

However, genetic variants that regulate stochastic fluctuation of gene expression and phenotypes in the offspring appear to be transmitted as an epigenetic or even Lamarckian trait. Furthermore, even the normal process of cellular differentiation from a single cell to a complex organism is not understood well from a mathematical point of view. There is increasingly strong evidence that stem cells are highly heterogeneous and in fact stochasticity is necessary for pluripotency. This process appears to be tightly regulated through the epigenome in development. Moreover, in these biological contexts, “stochasticity” is hardly synonymous with “noise”, which often refers to variation which obscures a “true signal” (e.g., measurement error) or which is structural, as in physics (e.g., quantum noise). In contrast, “stochastic regulation” refers to purposeful, programmed variation; the fluctuations are random but there is no true signal to mask.

This workshop will serve as a forum for scientists and engineers with an interest in computational biology to explore the role of stochasticity in regulation, development and evolution, and its epigenetic basis. Just as thinking about stochasticity was transformative in physics and in some areas of biology, it promises to fundamentally transform modern genetics and help to explain phase transitions such as differentiation and cancer.

This workshop will include a poster session; a request for poster titles will be sent to registered participants in advance of the workshop.

Speaker List:
Adam Arkin (Lawrence Berkeley Laboratory)
Gábor Balázsi (SUNY Stony Brook)
Domitilla Del Vecchio (Massachusetts Institute of Technology)
Michael Elowitz (California Institute of Technology)
Andrew Feinberg (Johns Hopkins University)
Don Geman (Johns Hopkins University)
Anita Göndör (Karolinska Institutet)
John Goutsias (Johns Hopkins University)
Garrett Jenkinson (Johns Hopkins University)
Andre Levchenko (Yale University)
Olgica Milenkovic (University of Illinois)
Johan Paulsson (Harvard University)
Leor Weinberger (University of California, San Francisco (UCSF))

Syndicated copies to:

NIMBioS Tutorial: Evolutionary Quantitative Genetics 2016

NIMBioS Tutorial: Evolutionary Quantitative Genetics 2016 by NIMBioS (nimbios.org)
This tutorial will review the basics of theory in the field of evolutionary quantitative genetics and its connections to evolution observed at various time scales. Quantitative genetics deals with the inheritance of measurements of traits that are affected by many genes. Quantitative genetic theory for natural populations was developed considerably in the period from 1970 to 1990 and up to the present, and it has been applied to a wide range of phenomena including the evolution of differences between the sexes, sexual preferences, life history traits, plasticity of traits, as well as the evolution of body size and other morphological measurements. Textbooks have not kept pace with these developments, and currently few universities offer courses in this subject aimed at evolutionary biologists. There is a need for evolutionary biologists to understand this field because of the ability to collect large amounts of data by computer, the development of statistical methods for changes of traits on evolutionary trees and for changes in a single species through time, and the realization that quantitative characters will not soon be fully explained by genomics. This tutorial aims to fill this need by reviewing basic aspects of theory and illustrating how that theory can be tested with data, both from single species and with multiple-species phylogenies. Participants will learn to use R, an open-source statistical programming language, to build and test evolutionary models. The intended participants for this tutorial are graduate students, postdocs, and junior faculty members in evolutionary biology.

Syndicated copies to:

Nick Lane and Philip Ball Discuss Mitochondria, Sex, and How to Live Longer

Nick Lane and Philip Ball Discuss Mitochondria, Sex, and How to Live Longer by Philip Ball (Nautil.us)
In his 2010 book, Life Ascending: The Ten Great Inventions of Evolution, Nick Lane, a biochemist at University College London, explores with eloquence and clarity the big questions of life: how it began, why we age and die, and why we have sex. Lane been steadily constructing an alternative view of evolution to the one in which genes explain it all. He argues that some of the major events during evolutionary history, including the origin of life itself, are best understood by considering where the energy comes from and how it is used. Lane describes these ideas in his 2015 book, The Vital Question: Why Is Life the Way It Is?. Recently Bill Gates called it “an amazing inquiry into the origins of life,” adding, Lane “is one of those original thinkers who make you say: More people should know about this guy’s work.” Nautilus caught up with Lane in his laboratory in London and asked him about his ideas on aging, sex, and death.

Biochemist Nick Lane explains the elements of life, sex, and aging in an engaging popular science interview.

Read more

Books by Nick Lane

Syndicated copies to:

Popular Science Books on Information Theory, Biology, and Complexity

The beginning of a four part series in which I provide a gradation of books and texts that lie in the intersection of the application of information theory, physics, and engineering practice to the area of biology.

Previously, I had made a large and somewhat random list of books which lie in the intersection of the application of information theory, physics, and engineering practice to the area of biology.  Below I’ll begin to do a somewhat better job of providing a finer gradation of technical level for both the hobbyist or the aspiring student who wishes to bring themselves to a higher level of understanding of these areas.  In future posts, I’ll try to begin classifying other texts into graduated strata as well.  The final list will be maintained here: Books at the Intersection of Information Theory and Biology.

Introductory / General Readership / Popular Science Books

These books are written on a generally non-technical level and give a broad overview of their topics with occasional forays into interesting or intriguing subtopics. They include little, if any, mathematical equations or conceptualization. Typically, any high school student should be able to read, follow, and understand the broad concepts behind these books.  Though often non-technical, these texts can give some useful insight into the topics at hand, even for the most advanced researchers.

Complexity: A Guided Tour by Melanie Mitchell (review)

Possibly one of the best places to start, this text gives a great overview of most of the major areas of study related to these fields.

Entropy Demystified: The Second Law Reduced to Plain Common Sense by Arieh Ben-Naim

One of the best books on the concept of entropy out there.  It can be read even by middle school students with no exposure to algebra and does a fantastic job of laying out the conceptualization of how entropy underlies large areas of the broader subject. Even those with Ph.D.’s in statistical thermodynamics can gain something useful from this lovely volume.

The Information: A History, a Theory, a Flood by James Gleick (review)

A relatively recent popular science volume covering various conceptualizations of what information is and how it’s been dealt with in science and engineering.  Though it has its flaws, its certainly a good introduction to the beginner, particularly with regard to history.

The Origin of Species by Charles Darwin

One of the most influential pieces of writing known to man, this classical text is the basis from which major strides in biology have been made as a result. A must read for everyone on the planet.

Information, Entropy, Life and the Universe: What We Know and What We Do Not Know by Arieh Ben-Naim

Information Theory and Evolution by John Avery

The Touchstone of Life: Molecular Information, Cell Communication, and the Foundations of Life by Werner R. Loewenstein (review)

Information Theory, Evolution, and the Origin of Life by Hubert P. Yockey

The four books above have a significant amount of overlap. Though one could read all of them, I recommend that those pressed for time choose Ben-Naim first. As I write this I’ll note that Ben-Naim’s book is scheduled for release on May 30, 2015, but he’s been kind enough to allow me to read an advance copy while it was in process; it gets my highest recommendation in its class. Loewenstein covers a bit more than Avery who also has a more basic presentation. Most who continue with the subject will later come across Yockey’s Information Theory and Molecular Biology which is similar to his text here but written at a slightly higher level of sophistication. Those who finish at this level of sophistication might want to try Yockey third instead.

The Red Queen: Sex and the Evolution of Human Nature by Matt Ridley

Grammatical Man: Information, Entropy, Language, and Life  by Jeremy Campbell

Life’s Ratchet: How Molecular Machines Extract Order from Chaos by Peter M. Hoffmann

Complexity: The Emerging Science at the Edge of Order and Chaos by M. Mitchell Waldrop

The Big Picture: On the Origins of Life, Meaning, and the Universe Itself (Dutton, May 10, 2016) 

In the coming weeks/months, I’ll try to continue putting recommended books on the remainder of the rest of the spectrum, the balance of which follows in outline form below. As always, I welcome suggestions and recommendations based on others’ experiences as well. If you’d like to suggest additional resources in any of the sections below, please do so via our suggestion box. For those interested in additional resources, please take a look at the ITBio Resources page which includes information about related research groups; references and journal articles; academic, research institutes, societies, groups, and organizations; and conferences, workshops, and symposia.

Lower Level Undergraduate

These books are written at a level that can be grasped and understood by most with a freshmen or sophomore university level. Coursework in math, science, and engineering will usually presume knowledge of calculus, basic probability theory, introductory physics, chemistry, and basic biology.

Upper Level Undergraduate

These books are written at a level that can be grasped and understood by those at a junior or senor university level. Coursework in math, science, and engineering may presume knowledge of probability theory, differential equations, linear algebra, complex analysis, abstract algebra, signal processing, organic chemistry, molecular biology, evolutionary theory, thermodynamics, advanced physics, and basic information theory.

Graduate Level

These books are written at a level that can be grasped and understood by most working at the level of a master’s level at most universities.  Coursework presumes all the previously mentioned classes, though may require a higher level of sub-specialization in one or more areas of mathematics, physics, biology, or engineering practice.  Because of the depth and breadth of disciplines covered here, many may feel the need to delve into areas outside of their particular specialization.

Syndicated copies to:

Probability Models for DNA Sequence Evolution

Probability Models for DNA Sequence Evolution (Springer, 2008, 2nd Edition) by Rick Durrett (math.duke.edu)

While browsing through some textbooks and researchers today, I came across a fantastic looking title: Probability Models for DNA Sequence Evolution by Rick Durrett (Springer, 2008). While searching his website at Duke, I noticed that he’s made a .pdf copy of a LaTeX version of the 2nd edition available for download.   I hope others find it as interesting and useful as I do.

I’ll also give him a shout out for being a mathematician with a fledgling blog: Rick’s Ramblings.

Book Cover of Probability Models for DNA Sequence Evolution by Richard Durrett
Probability Models for DNA Sequence Evolution by Richard Durrett
Syndicated copies to:

BIRS Workshop on Biological and Bio-Inspired Information Theory | Storify Stream

Over the span of the coming week, I'll be updating (and archiving) the stream of information coming out of the BIRS Workshop on Biological and Bio-Inspired Information Theory.

Over the span of the coming week, I’ll be updating (and archiving) the stream of information coming out of the BIRS Workshop on Biological and Bio-Inspired Information Theory.

 

Announcement: Special issue of Entropy: “Information Theoretic Incentives for Cognitive Systems”

Dr. Christoph Salge asked me to cross-post this notice from the Entropy site here.

Editor’s Note: Dr. Christoph Salge asked me to cross-post the following notice from the Entropy site here. I’m sure many of the readers of the blog will find the topic to be of interest.


 

Logo for the journal Entropy

 

Dear Colleagues,

In recent years, ideas such as “life is information processing” or “information holds the key to understanding life” have become more common. However, how can information, or more formally Information Theory, increase our understanding of life, or life-like systems?

Information Theory not only has a profound mathematical basis, but also typically provides an intuitive understanding of processes, such as learning, behavior and evolution terms of information processing.

In this special issue, we are interested in both:

  1. the information-theoretic formalization and quantification of different aspects of life, such as driving forces of learning and behavior generation, information flows between neurons, swarm members and social agents, and information theoretic aspects of evolution and adaptation, and
  2. the simulation and creation of life-like systems with previously identified principles and incentives.

Topics with relation to artificial and natural systems:

  • information theoretic intrinsic motivations
  • information theoretic quantification of behavior
  • information theoretic guidance of artificial evolution
  • information theoretic guidance of self-organization
  • information theoretic driving forces behind learning
  • information theoretic driving forces behind behavior
  • information theory in swarms
  • information theory in social behavior
  • information theory in evolution
  • information theory in the brain
  • information theory in system-environment distinction
  • information theory in the perception action loop
  • information theoretic definitions of life

Submission

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Entropy is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs).

Deadline for manuscript submissions: 28 February 2015

Special Issue Editors

Guest Editor
Dr. Christoph Salge
Adaptive Systems Research Group,University of Hertfordshire, College Lane, AL10 9AB Hatfield, UK
Website: http://homepages.stca.herts.ac.uk/~cs08abi
E-Mail: c.salge@herts.ac.uk
Phone: +44 1707 28 4490
Interests: Intrinsic Motivation (Empowerment); Self-Organization; Guided Self-Organization; Information-Theoretic Incentives for Social Interaction; Information-Theoretic Incentives for Swarms; Information Theory and Computer Game AI

Guest Editor
Dr. Georg Martius
Cognition and Neurosciences, Max Planck Institute for Mathematics in the Sciences Inselstrasse 22, 04103 Leipzig, Germany
Website: http://www.mis.mpg.de/jjost/members/georg-martius.html
E-Mail: martius@mis.mpg.de
Phone: +49 341 9959 545
Interests: Autonomous Robots; Self-Organization; Guided Self-Organization; Information Theory; Dynamical Systems; Machine Learning; Neuroscience of Learning; Optimal Control

Guest Editor
Dr. Keyan Ghazi-Zahedi
Information Theory of Cognitive Systems, Max Planck Institute for Mathematics in the Sciences Inselstrasse 22, 04103 Leipzig, Germany
Website: http://personal-homepages.mis.mpg.de/zahedi
E-Mail: zahedi@mis.mpg.de
Phone: +49 341 9959 535
Interests: Embodied Artificial Intelligence; Information Theory of the Sensorimotor Loop; Dynamical Systems; Cybernetics; Self-organisation; Synaptic plasticity; Evolutionary Robotics

Guest Editor
Dr. Daniel Polani
Department of Computer Science, University of Hertfordshire, Hatfield AL10 9AB, UK
Website: http://homepages.feis.herts.ac.uk/~comqdp1/
E-Mail: d.polani@herts.ac.uk
Interests: artificial intelligence; artificial life; information theory for intelligent information processing; sensor Evolution; collective and multiagent systems

Syndicated copies to:

Workshop Announcement: Entropy and Information in Biological Systems

I rarely, if ever, reblog anything here, but this particular post from John Baez’s blog Azimuth is so on-topic, that attempting to embellish it seems silly.

Entropy and Information in Biological Systems (Part 2)

John Harte, Marc Harper and I are running a workshop! Now you can apply here to attend:

Information and entropy in biological systems, National Institute for Mathematical and Biological Synthesis, Knoxville Tennesee, Wednesday-Friday, 8-10 April 2015.

Click the link, read the stuff and scroll down to “CLICK HERE” to apply. The deadline is 12 November 2014.

Financial support for travel, meals, and lodging is available for workshop attendees who need it. We will choose among the applicants and invite 10-15 of them.

The idea
Information theory and entropy methods are becoming powerful tools in biology, from the level of individual cells, to whole ecosystems, to experimental design, model-building, and the measurement of biodiversity. The aim of this investigative workshop is to synthesize different ways of applying these concepts to help systematize and unify work in biological systems. Early attempts at “grand syntheses” often misfired, but applications of information theory and entropy to specific highly focused topics in biology have been increasingly successful. In ecology, entropy maximization methods have proven successful in predicting the distribution and abundance of species. Entropy is also widely used as a measure of biodiversity. Work on the role of information in game theory has shed new light on evolution. As a population evolves, it can be seen as gaining information about its environment. The principle of maximum entropy production has emerged as a fascinating yet controversial approach to predicting the behavior of biological systems, from individual organisms to whole ecosystems. This investigative workshop will bring together top researchers from these diverse fields to share insights and methods and address some long-standing conceptual problems.

So, here are the goals of our workshop:

  •  To study the validity of the principle of Maximum Entropy Production (MEP), which states that biological systems – and indeed all open, non-equilibrium systems – act to produce entropy at the maximum rate.
  • To familiarize all the participants with applications to ecology of the MaxEnt method: choosing the probabilistic hypothesis with the highest entropy subject to the constraints of our data. We will compare MaxEnt with competing approaches and examine whether MaxEnt provides a sufficient justification for the principle of MEP.
  • To clarify relations between known characterizations of entropy, the use of entropy as a measure of biodiversity, and the use of MaxEnt methods in ecology.
  • To develop the concept of evolutionary games as “learning” processes in which information is gained over time.
  • To study the interplay between information theory and the thermodynamics of individual cells and organelles.

For more details, go here.

If you’ve got colleagues who might be interested in this, please let them know. You can download a PDF suitable for printing and putting on a bulletin board by clicking on this:

CECAM Workshop: “Entropy in Biomolecular Systems”

On Friday, I had an excellent and stimulating conversation with Arieh Ben-Naim about his recent writing and work, and he mentioned in passing that he had been invited to a conference relating to entropy and biology in Vienna.  A quick websearch found it quickly, and not having heard about it myself yet, I thought I’d pass it along to others who are regular readers and interested in the area.

The workshop on “Entropy in Biomolecular Systems” is being hosted by the Centre Européen de Calcul Atomique et Moléculaire (CECAM)

Logo for the Centre Européen de Calcul Atomique et Moléculaire (CECAM)

Location: DACAM, Max F. Perutz Laboratories, University of Vienna, Dr. Bohrgasse 9, A-1030, Vienna, Austria
Dates: May 14, 2014 to May 17, 2014

The workshop is being organized by:

  • Richard Henchman (University of Manchester, United Kingdom)
  • Bojan Zagrovic (University of Vienna, Austria)
  • Michel Cuendet (Swiss Institute of Bioinformatics, Lausanne, Switzerland and Weill Cornell Medical College, New York, USA)
  • Chris Oostenbrink (University of Natural Resources and Life Sciences, Austria)

It’s being supported by CECAM, the European Research Council, and the Royal Society of Chemistry’s Statistical Mechanics and Thermodynamics Group.

I’ll note that the registration deadline is on April 21 with a payment deadline of April 30, so check in quickly if you haven’t already.

The summary from the workshop website states:

This workshop brings together the world’s experts to address the challenges of determining the entropy of biomolecular systems, either by experiment or computer simulation. Entropy is one the main driving forces for any biological process such as binding, folding, partitioning and reacting. Our deficient understandng of entropy, however, means that such important processes remain controversial and only partially understood. Contributions of water, ions, cofactors, and biomolecular flexibility are actively examined but yet to be resolved. The state-of-the-art of each entropy method will be presented and explained, highlighting its capabilities and deficiencies. This will be followed by intensive discussion on the main areas that need improving, leading suitable actions and collaborations to address the main biological and industrial questions.

Further details on the workshop can be found on the CECAM website.

 

As always, details on other upcoming workshops and conferences relating to information theory and biology can be found on our ITBio Conferences/Workshops page.

 

 

Information Theory and Paleoanthropology

A few weeks ago I had communicated a bit with paleoanthropologist John Hawks.  I wanted to take a moment to highlight the fact that he maintains an excellent blog primarily concerning his areas of research which include anthropology, genetics and evolution.  Even more specifically, he is one of the few people in these areas with at least a passing interest in the topic of information theory as it relates to his work. I recommend everyone take a look at his information theory specific posts.

silhouette of John Hawks from his blog

I’ve previously written a brief review of John Hawks’ (in collaboration with Anthony Martin) “Major Transitions in Evolution” course from The Learning Company as part of their Great Courses series of lectures. Given my interest in the MOOC revolution in higher education, I’ll also mention that Dr. Hawks has recently begun a free Coursera class entitled “Human Evolution: Past and Future“. I’m sure his current course focuses more on the area of human evolution compared with the prior course which only dedicated a short segment on this time period.  Given Hawks’ excellent prior teaching work, I’m sure this will be of general interest to readers interested in information theory as it relates to evolution, biology, and big history.

I’d love to hear from others in the area of anthropology who are interested in information theoretical applications.

 

Syndicated copies to:

Renaissance for Information Theory in Biology

This year is the progenitor of what appears to be the biggest renaissance for the application of information theory to the area of biology since Hubert Yockey, Henry Quastler, and Robert L. Platzman’s “Symposium on Information Theory in Biology at Gatlinburg, Tennessee” in 1956. (I might argue it’s possibly even bigger than Claude Shannon’s Ph.D. thesis.)  It certainly portends to create a movement that will rapidly build upon and far surpass Norbert Weiner’s concept of Cybernetics and Ludwig von Bertalanffy’s concept of General Systems Theory.

This week John Baez has announced an upcoming three day workshop on “Entropy and Information in Biological Systems” to be hosted by the National Institute for Mathematical and Biological Synthesis in Knoxville, TN, tentatively scheduled for October 22-24, 2014.

Apparently unbeknownst to Baez, earlier this year Andrew Eckford, Toby Berger, and Peter Thomas announced a six day workshop on “Biological and Bio-Inspired Information Theory” to be hosted by the Banff International Research Station for Mathematical Innovation and Discovery scheduled for October 26-31, 2014 – just two days later!

What a bonanza!!

The BIRS workshop will be a bit more general in its approach while the NIMBioS workshop has a slightly tighter view specifically on maximum entropy as applied to biology.

Even more telling (and perhaps most promising) about the two workshops is the very heavy mathematical bent both intend to make their focus.  I have a theory that the bounds of science are held below the high water level of mathematics (aka are “bounded by” in mathematics-speak), so there is nothing more exciting than to see groups attempting to push the mathematics and its application further. It was both the lack of mathematical rigor and the general youth of biology (and specifically genetics and microbiology) in the 1950’s which heavily hampered the early growth of cybernetics as a movement. Fortunately this is no longer the case on either count. Now we just need more researchers who are more readily conversant in the two realms simultaneously.

Book Review: Werner Loewenstein’s “The Touchstone of Life: Molecular Information, Cell Communication, and the Foundations of Life”

The Touchstone of Life: Molecular Information, Cell Communication, and the Foundations of Life by Werner R. Loewenstein

Though there is a paucity of equations, particularly on the information theoretic side, Loewenstein does a fantastic job of discussing the theory and philosophy of what is going on in the overlapping fields of information theory and microbiology. (I will note that it is commonly held wisdom within publishing, particularly for books for the broader public, that the number of equations in a text is inversely proportional to the number of sales and I’m sure this is the reason for the lack of mathematical substantiation which he could easily have supplied.)

The Touchstone of Life (Book Cover)

This is a much more specific and therefore much better – in my mind – book than John Avery’s Information Theory and Evolution which covers some similar ground. Loewenstein has a much better and more specific grasp of the material in my opinion. Those who feel overwhelmed by Loewenstein may prefer to take a step back to Avery’s more facile presentation.

Loewenstein has a deft ability to describe what is going on and give both an up-close view with many examples as well as a spectacular view of the broader picture – something which is often missing in general science books of this sort. Readers with no mathematical or microbiology background can benefit from it as much as those with more experience.

One thing which sets it apart from much of its competition, even in the broader general science area of non-fiction, is that the author has a quirky but adept ability to add some flowery language and analogy to clarify his points. Though many will find this off-putting, it really does add some additional flavor to what might be dry and dull explication to many. His range of background knowledge, philosophy and vocabulary are second only (and possibly even on par or exceeding in some cases) that of Simon Winchester.

I’d highly recommend this book to people prior to their academic studies of biochemistry or molecular cell biology or to budding biomedical engineers prior to their junior year of study. I truly wish I had read this in 1994 myself, but alas it didn’t exist until a few years after. I lament that I hadn’t picked it up and been able to read it thoroughly until now.

For my part, his drastically differing viewpoint of the way in which biology should be viewed moving forward, is spot on. I am firmly a member of this new “school”. His final chapter on this concept is truly illuminating from a philosophical and theoretical view and I encourage people to read it first instead of last.

I’ll also note briefly that I’ve seen some reviews of this book which make mention of creationism or intelligent design and whether or not proponents of those philosophies feel that Loewenstein’s work here supports them or not, particularly since Loewenstein appeared on a panel with Dembski once. I will state for those who take a purely scientific viewpoint of things, that this book is written in full support of evolution and microbiology and doesn’t use the concept of “information” to muddy the waters the way many ID arguments are typically made.

Original review posted to GoodReads.com on 9/4/12

Syndicated copies to:

Microbiology and Eternal Life (A Short Play)

RNA: Grant me eternal life.
Genie: That’s not in my power to give.
RNA: Grant me then at least a wish?
Genie: (laughing) One wish?
RNA: Yes, only one.
Genie: Go ahead…
RNA: (with great wile and guile) Make me thrifty.
Genie: (with a cherry nod and a wink) Granted!
RNA: Thank you!

 
…and the RNA lived forever after.

Syndicated copies to:

David Christian’s “Maps of Time” and “Big History” – a Profound Thesis

Headshot of David Christian
Historian David Christian

David Christian, a trained historian, is one of the leading proponents of the relatively new concept of Big History, which I view as a sea-change in the way humans will begin to view not only the world but our place in it and what we might expect to come in the future.  His work presents a truly monumental and profound thesis and a drastically new framework for where humankind fits into the universe. Of the broad variety of works I’ve read in the past several decades, it is simply one of the most interesting and cohesive theses I’ve come across, and I highly and unreservedly recommend it to everyone I know.  I’d put it on par or above works like Jared Diamond’s Guns, Germs, and Steel and Matt Ridley’s The Rational Optimist among others for its broad impact on how I now view the world. For scientists and researchers it has the potential to be the philosophical equivalent of The Bible and in fact, like many religious texts, it is in effect a modern day “creation myth,” albeit one with a scientific underpinning.

Christian’s work was initially brought to my attention by an article in the Chronicle of Higher Education by Jeffrey R. Young in which he mentioned that Bill Gates was a big fan of Christian’s work and had recommended it himself at a TED conference. (Gates is now also a financial supporter of Christian’s Big History Project.) I myself was aware of the Learning Company’s generally excellent coursework offerings and within a few weeks got an audio copy of the course of forty-eight lectures to listen to on my daily commute.

I’ve now devoured both his rather large text on the subject as well as a lecture series he created for a course on the subject. Below are brief reviews of the two works.The magnum written opus Maps of Time: An Introduction to Big History is an interesting change of reference from a historical perspective combining the disciplines of physics, cosmology, astronomy, geology, chemistry, microbiology, evolutionary theory, archaeology, politics, religion, economics, sociology, and history into one big area of contiguous study based upon much larger timescales than those traditionally taken in the study of historical time periods. Though it takes pieces from many disciplines, it provides for an interesting, fresh, and much needed perspective on who humans are and their place in not only the world, but the entire universe.

By looking at history from a much broader viewpoint (billions of years versus the more common decades or even just a few centuries) one comes away with a drastically different perspective on the universe and life.

Book cover of "The Maps of Time"I’d highly recommend this to any general reader as early as they can find time to read through it, particularly because it provides such an excellent base for a variety of disciplines thereby better framing their future studies. I wish I had been able to read this book in the ninth or tenth grade or certainly at the latest by my freshman year in college – alas the general conception of the topic itself didn’t exist until after I had graduated from university.

Although I have significant backgrounds in most, if not all, of the disciplines which comprise the tapestry of big history, the background included in the book is more than adequate to give the general reader the requisite introductions to these subjects to make big history a coherent subject on its own.

This could be an extremely fundamental and life-changing book for common summer reading programs of incoming college freshman. If I could, I would make it required reading for all students at the high school level. Fortunately Bill Gates and others are helping to fund David Christian’s work to help introduce it more broadly at the high school and other educational levels.

Within David Christian’s opus, there is also a collection of audio lectures produced by The Learning Company as part of their Great Courses series which I listened to as well. The collection of forty-eight lectures is entitled Big History: The Big Bang, Life on Earth, and the Rise of Humanity (Great Courses, Course No. 8050). It provides a much quicker philosophical overview of the subject and doesn’t delve as deeply into the individual disciplines as the text does, but still provides a very cohesive presentation of the overall thesis.  In fact, for me, the introduction to the topic was much better in these audio lectures than it was in the written book. Christian’s lecture style is fantastic and even better than his already excellent writing style.

Because of the scale on which we look at the past, you should not expect to find in it many of the familiar details, names, and personalities that you’ll find in other types of historical teaching and writing. For example, the French Revolution and the Renaissance will barely get a mention. They’ll zoom past in a blur. You’ll barely see them. Instead, what we’re going to see are some less familiar aspects of the past. … We’ll be looking, above all, for the very large patterns, the shape of the past.

David Christian in Maps of Time: An Introduction to Big History

In the audio lectures Christian highlights eight major thresholds which he uses as a framework by which to view the 13.4 billion years of history which the Universe has presently traversed.  Then within those he uses the conceptualization of disparities in power/energy as the major driving forces/factors in history in a unique and enlightening way which provides a wealth of perspective on almost every topic (scientific or historical) one can consider. This allows one to see parallels and connections between seemingly disparate topics like the creations of stars and the first building of cities or how the big bang is similar to the invention of agriculture.

I can easily say that David Christian’s works on big history are some of the most influential works I’ve ever come across – and having experienced them, I can never see our universe in the same naive way again.

For those interested in taking a short and immediate look at Christian’s work, I can recommend his Ted Talk “The History of Our World in 18 Minutes” which only begins to scratch the surface of his much deeper and profound thesis: 

Given how profound the topic of big history is, I’m sure I’ll be writing about and referring to it often. Posts in relation to it can be found here with the tag: “big history“.

Added material below on 21-October-2016

Reading Progress

big-history-reading-progress-chart

Added material below on 23-October-2016

Highlights, Quotes, & Marginalia

Preface to the 2011 Edition
In Big History and the Future of Humanity, Fred Spier has built on an earlier work of his and on the work of Eric Chaisson to produce what is currently by far the most sophisticated attempt to construct a thematic scaffolding for big history. He carefully links the idea of increasing complexity with the associated themes of energy flows and the idea of goldilocks conditions—the notion that complexity can increase only under very special conditions and within quite exacting “boundary conditions.” Here are broad theoretical ideas that can help give greater depth and coherence to the story told within big history.
Highlight (yellow) – Location 443
big history promises to open up exciting new research agendas (including the meaning of complexity and energy flows, and the role of information across many disciplines),
Highlight (yellow) – Location 483
Introduction: A Modern Creation Myth?
sociologist Émile Durkheim referred to as “anomie”: the sense of not fitting in,
Highlight (yellow) – Location 550
Russian matryoshka doll
Highlight (orange) – Location 651
Accounts of the past that focus primarily on the divisions between nations, religions, and cultures are beginning to look parochial and anachronistic—even dangerous.
Highlight (yellow) – Location 702
capacious
Highlight (orange) – Location 753
Chaisson, Eric J. Cosmic Evolution: The Rise of Complexity in Nature. Cambridge, Mass.: Harvard University Press, 2001.
Highlight (green) – Location 795
Margulis, Lynn, and Dorion Sagan. Microcosmos: Four Billion Years of Microbial Evolution. London: Allen and Unwin, 1987.
Highlight (green) – Location 844
Maynard Smith, John, and Eörs Szathmáry. The Origins of Life: From the Birth of Life to the Origins of
Highlight (green) – Location 847
Spier, Fred. The Structure of Big History: From the Big Bang until Today. Amsterdam: Amsterdam University Press, 1996.
Highlight (green) – Location 878
Part I: The Inanimate Universe
Rig-Veda
Highlight (green) – 1. The First 300,000 Years: Origins of the Universe, Time, and Space > Location 907
This is very much how modern nuclear physics views the idea of a vacuum: it is empty but can nevertheless have shape and structure, and (as has been proved in experiments with particle accelerators) “things” and “energies” can pop out of the emptiness.
Highlight (yellow) – 1. The First 300,000 Years: Origins of the Universe, Time, and Space > Location 923
Popol Vuh, or “Council Book,” a sixteenth-century Mayan manuscript,
Highlight (green) – 1. The First 300,000 Years: Origins of the Universe, Time, and Space > Location 927
Dr. Lightfoot from Cambridge “proved” that God had created humans at exactly 9:00 AM on 23 October 4004 BCE.13
Highlight (yellow) – 1. The First 300,000 Years: Origins of the Universe, Time, and Space > Location 992
The particles that did find a partner were transformed into pure energy,
Highlight (yellow) – 1. The First 300,000 Years: Origins of the Universe, Time, and Space > Location 1088
Perhaps this is where dark matter and energy are hiding?
As an anonymous wit is supposed to have put it: “Hydrogen is a light, odorless gas which, given enough time, changes into people.”25
Highlight (yellow) – 1. The First 300,000 Years: Origins of the Universe, Time, and Space > Location 1131
The idea that form and matter are different expressions of the same underlying essence was proposed by the Italian Giordano Bruno as early as 1584, in a book called Concerning the Cause, Principle, and One.
Highlight (yellow) – 1. The First 300,000 Years: Origins of the Universe, Time, and Space > Location 1134
Eric Chaisson’s Cosmic Evolution (2001) is an attempt to think through the meaning of order and entropy at many different scales, from stars to microbes,
Highlight (green) – 1. The First 300,000 Years: Origins of the Universe, Time, and Space > Location 1394
The second law of thermodynamics ensures that all complex entities will eventually die; but the simpler the structure, the better its survival chances, which is why stars live so much longer than humans
Highlight (yellow) – 2. Origins of the Galaxies and Stars: The Beginnings of Complexity > Location 1521
Even in the densest part of the galaxy, the disk, regions of empty space normally contain only about one atom in each cubic centimeter. But in the earth’s atmosphere, there may be 25 billion billion molecules in the same space.15 And pouring though this matter is the energy emitted every second by the Sun. In other words, human history has taken place in a pocket of the universe that is dense in matter and packed with energy. It is the extraordinary richness and complexity of this environment that made life possible.
Highlight (yellow) – 2. Origins of the Galaxies and Stars: The Beginnings of Complexity > Location 1755
A Danish scientist, Nicholas Steno, first argued that fossils were the remains of organisms that had once lived on earth.
Highlight (yellow) – 3. Origins and History of the Earth > Location 1991
Charles Lyell first stated clearly what came to be known as the principle of uniformitarianism.
Highlight (yellow) – 3. Origins and History of the Earth > Location 1999
As the English philosopher Francis Bacon pointed out in 1620, it was easy to see from these maps that the continents looked like pieces of a jigsaw puzzle. This similarity was most striking when the west coast of Africa was matched up with the east coast of South America.
Highlight (yellow) – 3. Origins and History of the Earth > Location 2016
The idea that the continents really had drifted apart was given a thorough scientific basis in a book called The Origin of Continents and Oceans, written in 1915 by a German geographer, Alfred Wegener.
Highlight (yellow) – 3. Origins and History of the Earth > Location 2020
Gondwana sequence
Highlight (green) – 3. Origins and History of the Earth > Location 2024
uppermost layer of the earth (the lithosphere) consists of a number of rigid plates, like a cracked eggshell. There are eight large plates and seven smaller ones, as well as smaller slivers of material.
Highlight (yellow) – 3. Origins and History of the Earth > Location 2071
asthenosphere
Highlight (green) – 3. Origins and History of the Earth > Location 2072
Pangaea
Highlight (green) – 3. Origins and History of the Earth > Location 2109
Panthalass
Highlight (green) – 3. Origins and History of the Earth > Location 2109
Laurasia
Highlight (green) – 3. Origins and History of the Earth > Location 2110
Gondwanaland
Highlight (green) – 3. Origins and History of the Earth > Location 2110
Rodinia
Highlight (green) – 3. Origins and History of the Earth > Location 2113
Part II: Life On Earth
“The unfolding of events in the life cycle of an organism exhibits an admirable regularity and orderliness, unrivalled by anything we meet with in inanimate matter.”
Highlight (yellow) – 4. The Origins of Life and the Theory of Evolution > Location 2158
In Schrödinger’s famous phrase, each living organism seems to have an astonishing capacity for “continually sucking orderliness from its environment.”
Highlight (blue) – 4. The Origins of Life and the Theory of Evolution > Location 2166
Unlike stars or crystals, which are general, all-purpose antientropy machines, …
Highlight (yellow) – 4. The Origins of Life and the Theory of Evolution > Location 2180
Think of homoestasis vs longevity
Darwin rarely used the term evolution, perhaps because it seems to imply some sort of mystical force that drives biological change in particular directions and thus would contradict his own view of biological change as a more open-ended process.
Highlight (yellow) – 4. The Origins of Life and the Theory of Evolution > Location 2240
Herbert Spencer, who did the most to popularize the term,
Highlight (yellow) – 4. The Origins of Life and the Theory of Evolution > Location 2242
carunculated
Highlight (orange) – 4. The Origins of Life and the Theory of Evolution > Location 2297
Erasmus Darwin, suggested that species evolved so as to adapt better to their environments.
Highlight (yellow) – 4. The Origins of Life and the Theory of Evolution > Location 2315
In a book first published in 1809, the French naturalist Jean-Baptiste Lamarck suggested a possible mechanism. Perhaps minor changes acquired during a creature’s lifetime could somehow be passed on to its descendants.
Highlight (yellow) – 4. The Origins of Life and the Theory of Evolution > Location 2317
Time we spend in the gym does not guarantee that our children will be fit.
Highlight (yellow) – 4. The Origins of Life and the Theory of Evolution > Location 2323
Though epigenitics may be at work; see the studies of weight of self vs peers from c. 2010
Evolution works in fits and starts, according to the modern theory of “punctuated evolution,’ which was proposed by Niles Eldridge and Stephen Jay Gould in 1972.
Highlight (yellow) – 4. The Origins of Life and the Theory of Evolution > Location 2481
1920s by Alexander Oparin and J. B. S. Haldane, uses the basic ideas of evolutionary theory to explain not just the evolution of life on earth but also its initial appearance.
Highlight (yellow) – 4. The Origins of Life and the Theory of Evolution > Location 2512
But precisely how chemical evolution generated the first living organisms remains unclear. To understand these difficulties, we must break the problem into several levels. First, we need to explain how the basic raw materials of life were created: the chemical level. Second, we need to explain how these simple organic materials were assembled into more complex structures. Finally, we need to explain the origins of the precise mechanisms of reproduction encoded in the DNA that is present in all living organisms today. At present, we have reasonably good answers to the first question; we have plausible answers to the second question; and we are still puzzled by the third question.
Highlight (yellow) – 4. The Origins of Life and the Theory of Evolution > Location 2519
Harold Urey and his graduate student, Stanley Miller.
Highlight (yellow) – 4. The Origins of Life and the Theory of Evolution > Location 2537
Fred Hoyle and Chandra Wickramasinghe have argued that Earth was seeded with life from outside. This theory is known as Panspermia.
Highlight (yellow) – 4. The Origins of Life and the Theory of Evolution > Location 2572
A. G. Cairns-Smith has suggested that in shallow water, tiny crystals of clay may have provided a template for the formation of more complex molecules.
Highlight (yellow) – 4. The Origins of Life and the Theory of Evolution > Location 2590
Humans do not have the 60,000 to 80,000 genes we once believed were necessary to construct us but half that number, about 30,000. Roundworms have two-thirds as many genes as us (ca. 19,000), and fruit flies just under half (ca. 13,000); even Escherichia coli, a bacterium that inhabits our gut, may have as many as 4,000 genes. So, though constructing large organisms is tougher than constructing small organisms, the difference is not as great as we once imagined.
Highlight (yellow) – 5. The Evolution of Life and the Biosphere > Location 2782
It would seem that we’re not really becoming that more complex from a relative perspective here. What is the next major jump on the hockey stick?
As Margulis and Sagan put it: “For the macrocosmic size, energy, and complex bodies we enjoy, we trade genetic flexibility.”
Highlight (blue) – 5. The Evolution of Life and the Biosphere > Location 2867
The first extensive fossil evidence of multicellular organisms dates from the Ediacaran era, ca. 590 million years ago. But the fossil record of multicellular organisms really becomes abundant during the Cambrian era, from ca. 570 million years ago.
Highlight (yellow) – 5. The Evolution of Life and the Biosphere > Location 3032
In the middle of the nineteenth century, the German biologist Ernst Haeckel suggested that all single-celled organisms be classified within a separate kingdom of Protista. Then, in the 1930s, biologists realized that there was a fundamental difference between cells with nuclei and those without. As a result, they began to divide all organisms into two distinct kingdoms, the Prokaryota (organisms whose cells had no nuclei) and the Eukaroyta (organisms whose cells had nuclei). In some systems, the Eukaryota also include all multicellular organisms. In the second half of the twentieth century, powerful arguments emerged for the creation of separate kingdoms for fungi and for viruses (which are so simplified that they cannot even reproduce without hijacking the metabolic systems of other organisms). In the 1990s, Carl Woese proposed a new large classification to distinguish between the archaea and other forms of bacteria. Like all prokaryotes, archaea do not have nuclei; but unlike other prokaryotes they take in energy neither from sunlight nor from oxygen but from other chemicals.
Highlight (yellow) – 5. The Evolution of Life and the Biosphere > Location 3057
Chixculub
Highlight (orange) – 5. The Evolution of Life and the Biosphere > Location 3188
John Maynard Smith and Eörs Szathmáry’s The Origins of Life (1999) is a history of life on Earth, constructed around the central idea of the evolution of complexity.
Highlight (green) – 5. The Evolution of Life and the Biosphere > Location 3367
Part III: Early Human History: Many Worlds
Net primary productivity (NPP) is that portion of energy from sunlight that enters the food chain through photosynthesis and is turned into plant material.
Highlight (yellow) – 6. The Evolution of Humans > Location 3418
This means that the impact of human history will be visible on scales of at least a billion years.
Highlight (yellow) – 6. The Evolution of Humans > Location 3443
new ways of extracting resources from their environments.
Highlight (yellow) – 6. The Evolution of Humans > Location 3478
We have seen that the emergence of new forms of complexity always involves the creation of large structures within which previously independent entities are locked into new forms of interdependence and new rules of cooperation.7 Following this hint, we should expect to find that the transition to human history is primarily marked not by a change in the nature of humans as individuals but rather by a change in the way individuals relate to each other.
Highlight (yellow) – 6. The Evolution of Humans > Location 3482
learning collectively
Highlight (yellow) – 6. The Evolution of Humans > Location 3512
In an article first published in 1967, two biochemists working in the United States, Vincent Sarich and Alan Wilson, argued that much genetic change is subject to similar rules.
Highlight (yellow) – 6. The Evolution of Humans > Location 3589
neoteny
Highlight (yellow) – 6. The Evolution of Humans > Location 3640
“Millennium Man”
Highlight (yellow) – 6. The Evolution of Humans > Location 3690
another possible candidate for the oldest hominine, Ardipithecus ramidus kadabba,
Highlight (yellow) – 6. The Evolution of Humans > Location 3692
gracile
Highlight (orange) – 6. The Evolution of Humans > Location 3792
It is possible that tool use evolved through a process known as Baldwinian adaptation (named after the nineteenth-century American psychologist who first described it systematically). This is a form of evolutionary change that appears to combine Darwinian and cultural elements, because behavioral changes lead to changes in an animal’s lifeways, thereby creating new selective pressures that lead, over time, to genetic changes.
Highlight (yellow) – 6. The Evolution of Humans > Location 3814
the so-called Levallois or Mousterian tools.
Highlight (yellow) – 6. The Evolution of Humans > Location 3905
neoteny
Highlight (orange) – 6. The Evolution of Humans > Location 3945
Roger Lewin’s Human Evolution (4th ed., 1999)
Highlight (green) – 6. The Evolution of Humans > Location 3985
Steven Mithen has proposed that a number of once discrete brain modules, some of which may have been present in the earliest hominines, merged quite suddenly—perhaps within the last hundred thousand years—in a sort of linguistic “big bang.”
Highlight (yellow) – 7. The Beginnings of Human History > Location 4025
The Symbolic Species, Terrence Deacon
Highlight (green) – 7. The Beginnings of Human History > Location 4033
Two factors stand out: the volume and variety of the information being pooled, and the efficiency and speed with which information is shared.
Highlight (yellow) – 7. The Beginnings of Human History > Location 4257
In a deliberately provocative essay published in 1972, the anthropologist Marshall Sahlins describes the world of the Stone Age as “the original affluent society.”
Highlight (yellow) – 7. The Beginnings of Human History > Location 4323
In his simple but influential model of social structures, Eric Wolf has suggested that “kin-ordered” societies constitute a major type of human community, one that survives in many different forms even in the modern world.26
Highlight (green) – 7. The Beginnings of Human History > Location 4364
Australian archaeologist Rhys Jones referred to such techniques as “fire stick farming.”39 Fire stick “farmers” deliberately set fire to bushland in regular cycles. In part, their aim was to prevent buildups of combustible material that could lead to hotter and more dangerous fires. But by clearing away underbrush, fire stick farming also encouraged the growth of new plants that, in turn, attracted browsers that could be hunted. Recent research suggests that such techniques may have been used as early as 45,000 years ago.40
Highlight (yellow) – 7. The Beginnings of Human History > Location 4486
Part IV: The Holocene: Few Worlds
All of recorded human history has taken place within the Holocene interglacial.
Highlight (yellow) – 8. Intensification and the Origins of Agriculture > Location 4768
allopatric
Highlight (orange) – 8. Intensification and the Origins of Agriculture > Location 4860
loess
Highlight (orange) – 8. Intensification and the Origins of Agriculture > Location 4969
The Trap of Sedentism
Highlight (yellow) – 8. Intensification and the Origins of Agriculture > Location 5240
In fact, most of human history (chronologically speaking) has taken place in communities quite innocent of state power. Even in the villages of the early agrarian era, for most people, most of the time, the important relationships were personal, local, and fairly egalitarian. Most households were self-sufficient, and people dealt with each other as people rather than as the representatives of institutions.
Highlight (yellow) – 9. From Power over Nature to Power over People: Cities, States, and “Civilizations” > Location 5442
But exploitation, like symbiosis, is never simple or unambiguous. Like predation in the nonhuman world, it can take more or less brutal forms. Lynn Margulis and Dorion Sagan observe, “In the long run, the most vicious predators, like the most dread disease-causing microbes, bring about their own ruin by killing their victims. Restrained predation—the attack that doesn’t quite kill or does kill only slowly—is a recurring theme in evolution.”
Highlight (yellow) – 9. From Power over Nature to Power over People: Cities, States, and “Civilizations” > Location 5525
irrigation could raise agricultural productivity decisively, which is why irrigation has been one of the most revolutionary of all technological innovations.
Highlight (yellow) – 9. From Power over Nature to Power over People: Cities, States, and “Civilizations” > Location 5674
But population growth itself counts as a form of intensification, for in the era before fossil fuels, the energy resources available to human societies came mostly from human or animal muscle power.
Highlight (yellow) – 9. From Power over Nature to Power over People: Cities, States, and “Civilizations” > Location 5702
Inequality is what all top-down theories of state formation predict.
Highlight (yellow) – 9. From Power over Nature to Power over People: Cities, States, and “Civilizations” > Location 5730
as the sociologist Émile Durkheim first suggested, our thinking about the way the universe works often mirrors the way our own societies work.
Highlight (yellow) – 9. From Power over Nature to Power over People: Cities, States, and “Civilizations” > Location 5756
But most were used as sources of stored energy for their owners: where human labor power was as important a source of energy as oil is today, controlling energy meant controlling people. To make slaves more amenable to control, they were often separated at birth from their families. And, like domestic animals, many were deliberately kept in a state of infantile dependence that inflicted a sort of psychic amputation on them—they remained like children, and their helplessness made them easier to control. Both animal and human slaves could be controlled best if kept economically and psychically dependent on their owners.
Highlight (yellow) – 9. From Power over Nature to Power over People: Cities, States, and “Civilizations” > Location 5797
druzhiny
Highlight (orange) – 9. From Power over Nature to Power over People: Cities, States, and “Civilizations” > Location 6004
Outside the cities, they usually had little authority over the more localized forms of violence used to collect taxes, prosecute offenders or deal with banditry, or right local injustices. These powers were exercised by local elites or kinship groups. For most individuals, the righting of wrongs remained the duty of the household or kin group, which might seek the support of local patrons or officials.
Highlight (yellow) – 9. From Power over Nature to Power over People: Cities, States, and “Civilizations” > Location 6032
Sounds like modern day Muslim middle eastern practice now…
Wolf calls “tributes.” This is justification for regarding societies with states as an entirely new type of social structure. Wolf treats the emergence of what he calls “tribute-taking” societies as a major transformation in the lifeways and the organization of human societies.
Highlight (yellow) – 9. From Power over Nature to Power over People: Cities, States, and “Civilizations” > Location 6127
They include the emergence of dense populations, which generated a complex division of labor that posed new organizational problems, led to increased need for conflict resolution and to more frequent warfare, and encouraged the building of large monumental buildings as well as the creation of some form of writing.
Highlight (yellow) – 9. From Power over Nature to Power over People: Cities, States, and “Civilizations” > Location 6136
The demographic dynamism introduced into human history by agriculture ensured that sooner or later, humans, like termites, would face the novel challenge of living in dense communities of their own species. For all the local differences, the solutions humans found in different parts of the world turned out to be remarkably similar to each other—and also strikingly similar to those found by termites and other social insects.
Highlight (yellow) – 9. From Power over Nature to Power over People: Cities, States, and “Civilizations” > Location 6173
Marvin Harris’s classic essay, “The Origin of Pristine States” (1978).
Highlight (green) – 9. From Power over Nature to Power over People: Cities, States, and “Civilizations” > Location 6190
we can think of four main types of societies in this era: three—foragers, independent farmers, and pastoralists—lack states; one—agrarian civilizations—has states.
Highlight (yellow) – 10. Long Trends in the Era of Agrarian “Civilizations” > Location 6226
World historians have become increasingly sensitive to the importance of large systems of interaction, and have often analyzed them using the notion of world-systems. Immanuel Wallerstein, the originator of such theories, argued that particularly in the modern era, it was necessary to analyze not just particular nations or civilizations, but rather the larger networks of power and commerce in which they were entangled, because these networks explained features that could not be explained solely from the internal history of particular regions. Wallerstein called these networks “world-systems,” even though they did not literally embrace the entire world, on the grounds that in many regards they functioned as separate worlds.
Highlight (yellow) – 10. Long Trends in the Era of Agrarian “Civilizations” > Location 6354
Centers of gravity gave structure and shape to large networks of exchange, while hub regions were more lightweight and were more easily transformed by the exchanges that swept through them. So it was often in hub regions that significant innovations first became important because here was where they could have the greatest impact, while the mass and momentum of centers of gravity ensured that those regions normally changed more slowly.
Highlight (yellow) – 10. Long Trends in the Era of Agrarian “Civilizations” > Location 6421
During the reign of Sargon of Akkad (who ruled from ca. 2350 BCE for ca. 50 years), we have the first evidence for a new stage in state formation: the appearance of a state controlling several different city-states and their hinterlands.14
Highlight (yellow) – 10. Long Trends in the Era of Agrarian “Civilizations” > Location 6475
chinampa
Highlight (orange) – 10. Long Trends in the Era of Agrarian “Civilizations” > Location 6644
Rein Taagepera has tried to measure the areas ruled by “imperial systems” of Afro-Eurasia at different dates.
Highlight (yellow) – 10. Long Trends in the Era of Agrarian “Civilizations” > Location 6694
three other factors shaped the pace and nature of innovation in this period: population growth, the expanding activity of states, and increasing commercialization and urbanization.
Highlight (yellow) – 10. Long Trends in the Era of Agrarian “Civilizations” > Location 6721
Scale as a Source of Innovation
Highlight (yellow) – 10. Long Trends in the Era of Agrarian “Civilizations” > Location 6728
“the respiration of a social structure.”
Highlight (yellow) – 10. Long Trends in the Era of Agrarian “Civilizations” > Location 6868
One reason for their immense influence was the overwhelming importance of the agrarian sector. Where most forms of production relied on organic materials and energy sources, agricultural output set limits to the production not just of foodstuffs but also of clothing, housing, energy, productive implements, and even parchment and paper.33 Because agriculture was the main motor of economic growth in the agrarian era, rates of innovation in agriculture dominated medium-term economic, political, and even cultural cycles.
Highlight (yellow) – 10. Long Trends in the Era of Agrarian “Civilizations” > Location 6869
States as Sources of Accumulation
Highlight (yellow) – 10. Long Trends in the Era of Agrarian “Civilizations” > Location 6998
The most stable states and the wisest rulers protected the productive base of their societies by taxing lightly, maintaining basic infrastructure, upholding law and order, and encouraging growth in rural populations and agricultural output.
Highlight (yellow) – 10. Long Trends in the Era of Agrarian “Civilizations” > Location 7063
Thus, an eleventh-century CE Muslim prince from Tabaristan wrote in a book for his son, “Make it your constant endeavor to improve cultivation and to govern well; for understand this truth: the kingdom can be held by the army, and the army by gold; and gold is acquired through agricultural development and agricultural development through justice and equity. Therefore be just and equitable.”50
Highlight (yellow) – 10. Long Trends in the Era of Agrarian “Civilizations” > Location 7068
Powerful states spent freely on large prestige projects, including cities such as the Achaemenid capital, Persepolis. Such projects were designed to overawe subjects and rivals, but they also provided employment and attracted merchants and artisans.
Highlight (yellow) – 10. Long Trends in the Era of Agrarian “Civilizations” > Location 7086
In Muscovite history, the reign of Ivan the Terrible offers a horrifying example of the dangers of excessive predation.
Highlight (yellow) – 10. Long Trends in the Era of Agrarian “Civilizations” > Location 7113
First, elites in tribute-taking societies had to be specialists in coercion and management rather than in production.
Highlight (yellow) – 10. Long Trends in the Era of Agrarian “Civilizations” > Location 7118
Stable and long-lived polities such as that of China thrived in part because they were rich enough and durable enough to maintain predictable and relatively light levels of taxation, which gave peasants a greater stake in productivity-raising innovations.57
Highlight (yellow) – 10. Long Trends in the Era of Agrarian “Civilizations” > Location 7153
as Joel Mokyr has argued, technological innovation is unlikely to happen quickly where those who work lack wealth, education, and prestige, and those who are wealthy, educated, and have prestige know nothing about productive work.
Highlight (yellow) – 10. Long Trends in the Era of Agrarian “Civilizations” > Location 7157
Exchange, Commerce, and Urbanization
Highlight (yellow) – 10. Long Trends in the Era of Agrarian “Civilizations” > Location 7165
Thus urbanization itself dampened population growth, and it did so most decisively when cities grew fastest.
Highlight (yellow) – 10. Long Trends in the Era of Agrarian “Civilizations” > Location 7289
Though tributary states normally tolerated and sometimes encouraged commerce, their predatory methods and willingness to resort to force were ever-present threats to the freedoms needed for trade to flourish. There was therefore a fundamental long-term conflict between the methods of tribute takers and those of merchants; and as long as tributary elites dominated political systems, this conflict limited the productivity-raising potential of commercial activity.
Highlight (yellow) – 10. Long Trends in the Era of Agrarian “Civilizations” > Location 7293
Part V: The Modern Era: One World
Scythians north of the Black Sea more than 2,000 years ago:
Highlight (yellow) – 11. Approaching Modernity > Location 7432
But though they are on the whole less violent, personal relations in modern urban communities also lack the intimacy and continuity of those in most traditional societies. Increasingly, they are casual, anonymous, and fleeting. These changes may help explain the loss of a clear sense of values and meaning in modern lives, a subtle and disorienting alteration in the quality of modern life that the French sociologist Émile Durkheim referred to in the late nineteenth century as “anomie.”
Highlight (yellow) – 11. Approaching Modernity > Location 7618
Interesting in light of Civility for P.M. Forni.
The German sociologist Norbert Elias has argued that these changes have reached deep within our psyches, as modern forms of work and time discipline, enforced through the market, have shaped behavior in interpersonal relations, table manners, and attitudes toward sexuality. He has shown how the “emotional economy” typical in the modern world arises out of a relaxation of external restraints combined with an intensification of internal restraints: “The compulsions arising directly from the threat of weapons and physical force gradually diminish, and . . . those forms of dependency which lead to the regulation of the affects [feelings or emotions] in the form of self-control, gradually increase.”
Highlight (yellow) – 11. Approaching Modernity > Location 7622
A system of knowledge that is good at manipulating the material world is exactly what we need. Without such knowledge, we could not possibly support a human population of 6 billion.
Highlight (yellow) – 11. Approaching Modernity > Location 7645
As Daniel Headrick writes: “Knowledge is both cause and effect of economic growth, and the information industry has been the primary cause of the acceleration of technological change in the past 200 years.”
Highlight (yellow) – 11. Approaching Modernity > Location 7685
Necessity is not always the mother of invention.
Highlight (yellow) – 11. Approaching Modernity > Location 7718
in Britain iron makers had tried to use coal for almost two centuries before Abraham Darby showed them how to use coke in the early eighteenth century.
Highlight (yellow) – 11. Approaching Modernity > Location 7728
expanding networks of exchange encouraged specialization, which stimulated innovation in productive techniques—a type of growth we can refer to as Smithian.42
Highlight (yellow) – 11. Approaching Modernity > Location 7768
From Joel Mokyr, The Lever of Riches: Technological Creativity and Economic Progress (Oxford: Oxford University Press, 1992),
Highlight (green) – 11. Approaching Modernity > Location 7772
the very nature of most premodern states suggests that as a general rule, in agrarian civilizations tribute-taking generated more wealth and certainly more power than commercial exchanges. This differential helps us understand what might at first appear puzzling: though commercial networks are as old as agrarian civilization, their impact on rates of innovation has been limited until the past two or three centuries. Why, then, did commercial exchanges suddenly become so much more significant in the modern era? Did they reach some critical threshold?
Highlight (yellow) – 11. Approaching Modernity > Location 7780
And what then is the next threshold? For think of what the Internet is doing to the entertainment industry and their reticence to go along with it.
Speaking generally, it is the steepness of this gradient of wealth that accounts for capitalism’s remarkable dynamism, just as the large temperature gradient between the Sun and the space surrounding it drives complex processes on Earth.
Highlight (yellow) – 11. Approaching Modernity > Location 7819
is the steepness of the gradient that drives wealth so efficiently through capitalist societies and that helps explain why, paradoxically, modern states have to be so much larger and more complex than the states of the tributary world.
Highlight (yellow) – 11. Approaching Modernity > Location 7823
So the onus is on the workers to ensure that their labor is productive enough to find a buyer. In this way, the economic lash can stimulate genuine, even creative, self-discipline, whereas the overseer’s whip can generate no more than grudging conformity.
Highlight (yellow) – 11. Approaching Modernity > Location 7843
J. L. Anderson’s Explaining Long-Term Economic Change (1991) is a useful introduction to the theoretical literature.
Highlight (green) – 11. Approaching Modernity > Location 7920
Robert Lopez, has called the “commercial revolution of the Middle Ages” a fundamental turning point in modern world history.
Highlight (yellow) – 12. Globalization, Commercialization, and Innovation > Location 8067
Well-to-do merchants accumulate goods and redouble their profits, while the less well-to-do sit in their shops and sell. They control the markets and daily enjoy their ease in the cities. They take advantage of the pressing needs of the government to sell at twice the normal price. Their sons do not plough or hoe. Their daughters do not raise silkworms or weave. They have fancy clothing and stuff themselves on millet and meat. They earn fortunes while suffering none of the hardships which the farmers suffer. Their wealth enables them to hobnob with princes and marquises, and to dispose of greater power than the officials.29
Highlight (yellow) – 12. Globalization, Commercialization, and Innovation > Location 8185
This quote about 2nd century BCE China sounds a lot like modern day China.
this process was completed by 1279 after the conquest of South China by the Mongols under Kublai Khan. After reunification, two of the three conditions encouraging states to support commercialization (small size and intense rivalries) vanished, and the third (easy access to rich trading systems) lasted only slightly longer.
Highlight (yellow) – 12. Globalization, Commercialization, and Innovation > Location 8270
Charles Tilly’s Coercion, Capital, and European States, AD 990–1992 (rev. ed., 1992).
Highlight (green) – 12. Globalization, Commercialization, and Innovation > Location 8567
Indeed, Spain depended so heavily on American silver that when the supply ran out in the seventeenth century, its commercial and political influence declined.
Highlight (yellow) – 12. Globalization, Commercialization, and Innovation > Location 8628
piratical
Highlight (orange) – 12. Globalization, Commercialization, and Innovation > Location 8631
wealth. The mercantilist policies of European states in the seventeenth century—such as the Navigation Acts of the English commonwealth, which protected British commerce within British colonies—are good examples of new government attitudes toward commerce and the actions that these changes encouraged. Also illustrating this trend is the proliferation throughout Europe of patent laws, which were pioneered in Venice in the fifteenth century. Governments also began to promote innovation through the founding of scientific societies or the offering of prizes.
Highlight (yellow) – 12. Globalization, Commercialization, and Innovation > Location 8641
Over time, commercialization transformed traditional tributary elites. Such transformation was most likely to occur when demands on elite incomes rose sharply in environments where commercial revenues were available for the taking. The English wool trade offers a classic example, for it tempted landowners to clear the land of tenants and replace them with sheep, particularly in the sixteenth century, when new land became available as a result of the dissolution of the monasteries.
Highlight (yellow) – 12. Globalization, Commercialization, and Innovation > Location 8648
“it is gain, whether vile or sordid, that derogates from nobility, whose proper role is to live off rents.”
Highlight (yellow) – 12. Globalization, Commercialization, and Innovation > Location 8656
the invention in France of the Jacquard loom, which pioneered the use of digital coding as a form of mechanical control (1801);
Highlight (yellow) – 13. Birth of the Modern World > Location 8951
As early as 1837, the French revolutionary Blanqui used the term industrial revolution
Highlight (yellow) – 13. Birth of the Modern World > Location 8956
For most rural dwellers, these changes were catastrophic.
Highlight (yellow) – 13. Birth of the Modern World > Location 9024
This is now what is happening in most of the rest of the world now.
The appearance of societies in which most people depended entirely on markets for their subsistence was a new phenomenon, and it gave a tremendous stimulus to commercial production of goods of mass consumption.
Highlight (yellow) – 13. Birth of the Modern World > Location 9097
The idea that atmospheric pressure was a potential source of mechanical power had a history going back at least to the sixteenth century, and it may have been familiar in China as well as in Europe.23
Highlight (yellow) – 13. Birth of the Modern World > Location 9126
In 1718, a new owner, Thomas Lombe, in an early example of planned industrial espionage, stole techniques already in use in Italy to set up an improved factory.
Highlight (yellow) – 13. Birth of the Modern World > Location 9137
Richard Arkwright’s water frame, James Hargreaves’s spinning jenny, and Samuel Crompton’s spinning mule, a modification of the jenny.24
Highlight (yellow) – 13. Birth of the Modern World > Location 9140
Karl Polanyi argues in a classic study of modernity,
Highlight (green) – 13. Birth of the Modern World > Location 9336
Where literacy spread, knowledge became more abstract and less personal, and abstract knowledge began to acquire an authority quite independent from the prestige of particular teachers.
Highlight (yellow) – 13. Birth of the Modern World > Location 9375
In the nineteenth century, beginning in Germany, science itself began to be incorporated into entrepreneurial activity as companies set up laboratories specifically to raise productivity and profits. By the late nineteenth century, scientific research was taking a leading role in processes of innovation that might have simply petered out if they had continued to rely on the technical and practical skills of individual entrepreneurs and artisans.
Highlight (yellow) – 13. Birth of the Modern World > Location 9389
Think about how this is done now and how much of it is done by universities instead of by industry. Where is his innovation happening in the future?
The modern world is ruled by larger and more impersonal forces, from faceless bureaucracies to abstractions such as “inflation,” or “the rule of law.” Where abstract forces take over the work of coercion from the landlord, the executioner, and the overseer, it is not surprising that there should emerge cosmologies ruled by equally abstract forces.
Highlight (yellow) – 13. Birth of the Modern World > Location 9395
Joel Mokyr, The Lever of Riches (1990),
Highlight (green) – 13. Birth of the Modern World > Location 9532
Charles Tilly, Coercion, Capital, and European States, AD 990–1992 (rev. ed., 1992), is good on some of the political changes associated with the Industrial Revolution.
Highlight (green) – 13. Birth of the Modern World > Location 9533
During the “great depression” of the 1870s, it became apparent for the first time that economic growth could falter because of overproduction as well as underproduction.
Highlight (yellow) – 14. The Great Acceleration of the Twentieth Century > Location 9700
Over the following decades, it became clear that in a world of steadily increasing productivity, the problem of finding (or creating) markets would shape the rhythms of economic activity much as the problem of insufficient productivity had done in the agrarian era. As a result, the modern era is dominated by cycles of activity with a different (normally a shorter) periodicity, which we know as business cycles.
Highlight (yellow) – 14. The Great Acceleration of the Twentieth Century > Location 9702
Indeed, lifestyles have changed so greatly that they may be exerting a significant evolutionary impact on human bodies.
Highlight (yellow) – 14. The Great Acceleration of the Twentieth Century > Location 9715
The tensions and dislocations of the hurricane of change affecting the entire globe will ensure that conflict remains endemic, and modern weaponry will ensure that local conflicts continue to cause great suffering.
Highlight (yellow) – 14. The Great Acceleration of the Twentieth Century > Location 10017
Lester Brown argues that “while the Agricultural Revolution transformed the earth’s surface, the Industrial Revolution is transforming the earth’s atmosphere.”
Highlight (yellow) – 14. The Great Acceleration of the Twentieth Century > Location 10049
Part VI: Perspectives On The Future
“With chaos, it is sensitivity to initial conditions that makes the dynamics unpredictable. With emergent properties, it is the general inability of observers to predict the behavior of nonlinear systems from an understanding of their parts and interactions.”
Highlight (yellow) – 15. Futures > Location 10163
it is better than doing nothing at all, just as studying the form at a racetrack is better than tossing a coin. In the long run, you will end up with more money if you study the form.
Highlight (yellow) – 15. Futures > Location 10245
the space technologies envisioned by the Russian schoolteacher Konstantin Tsiolkovsky, which enabled the first human to leave Earth on 12 April 1961 and the first human to land on another heavenly body on 21 July 1969,
Highlight (yellow) – 15. Futures > Location 10468
Appendix 2: Chaos and Order
But the patterns we detect are really there, and their existence is one of the great puzzles of the universe. Why is there order of any kind? And what rules allow the creation and evolution of ordered structures?
Highlight (yellow) – Location 10964
On Earth, the temperature differential between our sun and surrounding space provides the free energy needed to create most forms of complexity, including ourselves; energies created early in the history of our solar system drive the internal heat battery of Earth, which drives plate tectonics. These differentials enable energy to flow, and energy flows make patterns possible. And given enough time, the mere possibility of pattern makes it likely that patterns of many different kinds will eventually appear.
Highlight (yellow) – Location 11024
After the first problem—explaining how order of any kind is possible—is addressed, the second problem remains. How did complex entities emerge, and, once they had emerged, how did they sustain themselves long enough to be noticed by us (or to be us)?
Highlight (yellow) – Location 11037
Paradoxically, the tendency toward increasing entropy—the drive toward disorder—may itself be the engine that creates order.
Highlight (yellow) – Location 11039
The drive toward disorder seems to create new forms of order, just as the energy of falling water can cause droplets of water to splash upward, or a river’s current can create eddies in which small amounts of water flow against the main current.
Highlight (yellow) – Location 11044
Roughly speaking, the more complex a phenomenon is, the denser the energy flows it must juggle and the more likely it is to break down. So we should expect that as entities become more complex, they become less stable, shorter-lived, and rarer. Perhaps even a slight increase in complexity can sharply increase their fragility and, therefore, their scarcity.
Highlight (yellow) – Location 11064
What we can do is to describe some of the ways in which complex structures emerge. The fundamental rule seems to be that complexity normally emerges step by step, linking already existing patterns into larger and more complex patterns at different scales.
Highlight (yellow) – Location 11072
new rules of construction and change seem to come into play. These are known as emergent properties,
Highlight (yellow) – Location 11076
Notes
“Leibig’s Law of the Minimum . . . states that populations will be limited by critical resources (e.g., water) that are in shortest supply” (Allen W. Johnson and Timothy Earle, The Evolution of Human Societies, 2nd ed. [Stanford: Stanford University Press, 2000], pp. 14–15).
Highlight (green) – Location 11456
articles, “Immunological Time Scale for Hominid Evolution”; it was published in Science, 1 December 1967, pp. 1200–1203.
Highlight (green) – Location 11492
There is a good short survey of theories of growth in J. L. Anderson, Explaining Long-Term Economic Change (Basingstoke: Macmillan, 1991); and see the survey in Mokyr, The Lever of Riches, chap. 7 (“Understanding Technological Progress”).
Highlight (green) – Location 12288
Guide to highlight colors

Yellow–general highlights and highlights which don’t fit under another category below
Orange–Vocabulary word; interesting and/or rare word
Green–Reference to read
Blue–Interesting Quote
Gray–Typography Problem
Red–Example to work through

Editor’s Note: Data relating to reading progress was added to this post on 10/21/16. Data relating to highlights, quotes, and marginalia added on 10/23/16.

Syndicated copies to:

Synthetic Biology’s Hunt for the Genetic Transistor | IEEE Spectrum

Synthetic Biology's Hunt for the Genetic Transistor (spectrum.ieee.org)
How genetic circuits will unlock the true potential of bioengineering

This is a great short article on bioengineering and synthetic biology written for the layperson. It’s also one of the best crash courses I’ve read on genetics in a while.

Media_httpspectrumiee_kzdjg