I’ve been moving towards the same setup for my Twitter use for the last several months, but with different topic-based lists. It really does make things a lot better, by allowing proper curation of what I see. While moving over I discovered that Tweetbot (my client of choice) will let me set a list as my "home" view, so I don’t have to jump between multiple lists in one tab, or load into an empty timeline. I have my hobby feed as the default, and use the lists view primarly for my news and current events list.