Apologies for the delay, I've cleared out the caches as @judell indicated and haven't seen any issues for the last few days. I had a large number of tags, though I don't think the number was as large as @TylerRick's.

I feel like @TylerRick has done an excellent job of discussing the pros/cons of the user facing issues and concerns. I'm glad to know that this is where these reside so I can fix misspellings and can change the local cache to better match some of my personal website's pre-existing taxonomies so that there is a 1-1 onto mapping of my Hypothesis tags and those on my site (or at least for the top 20% of most commonly used tags) for syndicating content more easily.

For the record, and for @robertknight's query, below is my version information:
account: Chris Aldrich (acct:chrisaldrich@hypothes.is)
userAgent: Mozilla/5.0 (Windows NT 10.0; Win64; x64) AppleWebKit/537.36 (KHTML, like Gecko)
Chrome/79.0.3945.130 Safari/537.36
version: 1.272.0

My recollection of the crashes is that they were typically on tags that began with the letters in, though there were one or two instances with other short tag fragments. Almost all my data is public facing, so viewing my tags on the public instance might be illustrative.

Perhaps it's spurious, but @TylerRick and I are both sitting around the 2,000 annotation mark and may be at the upper end of the bell curve of users. Jon (~5,300) and Jeremy (~3,600) are the only people I'm aware of with more. user:esperluette may be an interesting test case given the high number of their tags that begin with the hw- combination.