But tonight Twitter began to change the landscape of how Hollywood, and in particular the representation segment, does its day-to-day business.
It began with the news that Alyssa Milano’s ABC series ROMANTICALLY CHALLENGED, which premiered on April 19th earlier this year, had been cancelled. Michael Ausiello of the Ausiello Files for Entertainment Weekly broke the story online at 7:44 pm (Pacific) and tweeted out the news. Alyssa Milano saw the news on Twitter about an hour later, and at 8:45 pm, she out her disappointment to the world.
Just found out #romanticallychallenged was cancelled through Twitter! How crazy is that shit?
— Alyssa Milano (@Alyssa_Milano)
Her agent/manager is going to have a fire to put out tomorrow, if it doesn’t burn itself into oblivion tonight! If anything, her agent typically could have or should have been amongst one of the first to know, generally being informed by the studio executive in charge of the project or potentially by the producer of the show who would also have been in that first round to know about the cancellation. And following the news from the network, Alyssa should have been notified immediately.
Typically this type of news is treated like pure commodity within the representation world. If a competing agent, particularly one who wanted a client like Alyssa, to move to their agency, they would dig up the early news, call her at home, break the bad news early and fault the current representative for dropping the ball and not doing their job. Further, the agent would likely put together a group of several new scripts (which the servicing agent either wouldn’t have access to or wouldn’t have sent her) and have them sent over to her for her immediate consideration. Suddenly there’s an unhappy client who is seriously considering taking their business across the street.
The major difference here is that it isn’t a competing agent breaking the bad news, but the broader internet! Despite the brevity of the less than 140 characters Ms. Milano had, it’s quite obvious that she’s both shocked and a bit upset at the news. We cannot imagine that she’s happy with the source of the news; it’s very likely that her representation got an upset call this evening which they’re currently scurrying to verify and then put out the subsequent fire.
Beyond this frayed relationship, there is also the subsequent strain on the relationships between representation and the overseeing studio executive(s), studio/network chief, and potentially further between the Agency and the Network over what is certain to be one of the more expensive television talent deals in the business right now.
We’re sure there will be a few more agents, managers, and attorneys who sign up for Twitter accounts tomorrow and begin monitoring their clients’ brands more closely on the real-time web.
[As a small caveat to all of this, keep in mind that the show was picked up in early August last year and only aired four episodes premiering in April of this year, so from a technical point of view, the show’s cancellation isn’t a major surprise simply given the timing of the pick-up and the premiere, the promotional push behind the show, or the show’s ratings. Nevertheless, this is sure to have an effect on the flow of business.]
Imagine having your back cut open, part of your spine removed, a stabilizing device that resembles a mini oil rig mounted on your back, the outer membrane of your spinal cord sliced open and experimental stem cells injected into it -- all for the advancement of science because it's not expected to benefit you.
Atlanta, Georgia — Imagine having your back cut open, part of your spine removed, a stabilizing device that resembles a mini oil rig mounted on your back, the outer membrane of your spinal cord sliced open and experimental stem cells injected into it — all for the advancement of science because it’s not expected to benefit you.
John Cornick, 51, did just that earlier this month as part of a groundbreaking clinical trial.
Almost a year ago, Cornick was told he had ALS — better known as Lou Gehrig’s disease. The diagnosis left him “fairly devastated,” he says.
He knew the prospects were grim because there is no cure.
But John wasn’t giving up so quickly, nor was his wife, Gina.
“I knew he was a fighter from the beginning and he really wanted to do something,” Gina Cornick says. She found information about a clinical trial on online and immediately signed him up, even though she had no idea where it was being held.
ALS destroys the nerve cells in the brain and spine which control muscle movement. When the brain can no longer tell muscles to move, they eventually die, depriving the patient of the ability to move arms and legs and eventually breathe.
The goal of this phase 1 trial is to determine whether fetal stem cells can safely be injected into the spinal cord. Ultimately, researchers hope to show that these cells may slow or halt the progression of the fatal disease.
But for now, the only goal is establishing safety.
The Cornicks live in North Carolina, just a few hours from Atlanta, Georgia’s Emory University, the site of the trial. It is the first FDA-approved clinical trial to inject fetal stem cells directly into the spinal cord of an adult.
Dr. Jonathan Glass, director of Emory’s ALS center, is overseeing the trial. Cornick and two previous patients in the trial are heroes, says Glass, because at this point, the trial will likely produce only information, not results.
“In reality what do these patients have? Time, families and their life and we’re putting all of these at risk,” says Glass.
Dr. Lucie Bruijn, science director of the ALS Association, says the progress being made in this clinical trial is exciting. “We’ve been able to move it forward … from animal testing now into actual patients.” The treatment had not been tried in humans before.
Glass hopes this trial will lead to a new form of treatment for people with ALS. “We’re testing multiple things: We’re testing the safety of the surgery; we’re testing the cells; we’re testing immunosuppressants[because scientists do not know whether the body will reject the cells].” They are also testing how well Cornick handles this major surgical procedure, says Glass.
“After we’re finished with the first 12 or 18 patients we will know whether this is surgery that patients can tolerate.”
As he was prepped for surgery, Cornick was hopeful but realistic. “Well, of course you’d like to get up and walk … but I know that’s not going to happen.”
The stem cells used in the surgery are shipped overnight from Maryland, where Neuralstem, the company funding the trial, is based. The stem cells’ source is donated tissue from the spinal cord of an 8-week old aborted fetus, which was donated to the company. The company has developed a method that enables growth of millions of stem cells from this single source of human nerve stem cells.
Before the surgery can begin, a technician at Emory has to verify that a majority of stem cells made it to Atlanta alive. At least 70 percent have to be viable. In this case three samples under the microscope showed 85 percent of the cells arrived alive.
Lead researcher Dr. Eva Feldman, a neurologist at the University of Michigan, designed the trial just four years ago. After a lot of animal testing, her team determined that using fetal nerve stems rather than human embryonic or adult stem cells (such as bone marrow stem cells) was most effective, she says.
Stem cells have the ability to turn into different cells in the body. However, human embryonic stem cells, which come from 4- or 5-day-old embryos, also been found to sometimes turn into cancer cells. Fetal stem cells, such as those used in this trial, are a few weeks older and have already taken on a specific identity — in this case nerve cells.
Feldman says the fetal stem cells used in this trial did not become any of the unwanted cell types. “That’s very, very important,” she says.
Animal testing also proved very useful when it came to figuring out how to actually inject the stem cells. Emory University’s neurosurgeon Dr. Nicholas Boulis invented the device that holds the needle that injects the stem cells. The goal is to inject the cells without injuring the spine and causing even more paralysis. He practiced on 100 pigs before attempting the procedure on a human.
Boulis says it’s critical that the injection be done in a very slow and controlled way.
“If you inject quickly, you’re going to create pressure at the head of the needle and that can cause damage,” Boulis says. That pressure can also inflate an area in the spinal cord which could cause the stem cells to seep back out of the cord when the needle is pulled out, he says. “So by pumping [cells] in slowly you have more security that you are not going to have reflux and you’re not going to have damage.”
Dr. Jeffrey Rothstein, who heads the ALS research center at Johns Hopkins University and is not connected to this trial, said work on this method is a big achievement. “This is purely about how to surgically deliver cellular therapy to spinal cord,” he says. “It’s never been done before.”
After the spinal cord was exposed, the injections began. Cornick got five — each one contains about 100,000 stem cells.
The four-and-a-half hour surgery went smoothly, Boulis, says. “There were no surprises.”
A day after surgery, Cornick was lying flat in a hospital bed, chatting and laughing with some friends from North Carolina.
One week after surgery, he says he felt amazingly well and was still hopeful the cells would do some good for him.
Two weeks later Cornick’s stitches were removed and he was able to drive home. But he will be making frequent visits back to Atlanta as Glass and his team continue to monitor him.
Neuralstem’s Chief Scientific Officer Karl Johe says after the trial’s safety board reviews all existing data, including Cornick’s results, a fourth patient can be treated with the stem cells.
“Patients Four, Five and Six will receive twice as many [stem cell] injections,” Johe says. They will get five more injections on the other side of the spinal cord compared with Cornicks’s surgery.
Cornick expects the researchers will follow his progress for a long time. He says he understands the need for people to be willing to participate in experimental research like this.
“For me it just seemed like the right thing to do. I almost felt I had an obligation to do this,” he says. “To help other people and myself.”
For the first time in the United States, stem cells have been directly injected into the spinal cord of a patient, researchers announced Thursday.
ATLANTA, Georgia (CNN) — For the first time in the United States, stem cells have been directly injected into the spinal cord of a patient, researchers announced Thursday.
Doctors injected stem cells from 8-week-old fetal tissue into the spine of a man in his early 60s who has advanced, or amyotrophic lateral sclerosis. It was part of a clinical trial designed to determine whether it is safe to inject stem cells into the spinal cord and whether the cells themselves are safe.
ALS is a fatal neurodegenerative disease that causes the deterioration of specific nerve cells in the brain and spinal cord called motor neurons, which control muscle movement. About 30,000 Americans have ALS at any given time, according to the ALS Association.
There is no cure for ALS, which is better known asdisease, named after the New York Yankees’ first baseman and Hall of Famer who retired from baseball in the 1930s after being diagnosed with the disease.
As the illness progresses, patients lose their ability to walk, talk and breathe. Patients usually die within two to five years of diagnosis, according the ALS Association.
Neuralstem Inc., a Rockville, Maryland-based biotech company, received approval from the U.S. Food and Drug Administration to conduct the clinical trial in September. The company is fully funding the research and provides the stem cells that are being injected into the patients.
Neuralstem announced the start of the clinical trial in a news release Thursday.
Longtime ALS researcher and University of Michigan neurologist Dr. Eva Feldman is overseeing the first human clinical trial of a stem cell treatment in ALS patients.
“We are entering a new era of cell therapeutics for ALS, and in my opinion, it is an new era of hope for patients with ALS,” Feldman said.
At least 12 patients are expected to participate in this early research. They are to receive the stem cell transplants at Emory University in Atlanta, Georgia.
“This is the first study to see if the invasive injection into the spinal cord is safe for the patient,” said Lucie Bruijn, science director of the ALS Association.
This first patient in the clinical trial received several injections of stem cells into the lumbar region of the spinal cord, the area that controls leg function, because most ALS patients first lose muscle function in their legs, according to Karl Johe, Neuralstem’s chairman and chief scientific officer.
Bruijn says there have been a few other occasions outside the United States in which fetalhave been injected into a patient, “but not necessarily using a very [rigorous] trial design.” She adds that there were also a couple of small studies in Italy that injected other types of stem cells into a few patients but that this is the first FDA-approved trial in the United States.
“Our biggest hope for stem cells is to significantly slow the progression the disease,” Bruijn said.
The ALS Association is not providing funding for this clinical trial, but it has supported the work of Dr. Nick Boulis, the Emory neurosurgeon who developed the surgical technique used to inject the stem cells.
Johe invented the technology that allows the company to manufacture billions of copies of stem cells that are taken from a single source of spinal cord cells: cells that were extracted from fetal tissue, which was donated to the company.
“The cells are human neural stem cells,” Johe said, acknowledging that the introduction of stem cells is a very invasive procedure.
“What we are attempting is a novel approach by directly injecting them into the middle of the spinal cord, which to our knowledge has never been done before,” Johe said.
Researchers plan to follow this and future patients participating in this trial for a long time to determine the safety of the procedure.
These particular stem cells — which came from the spinal cord of an 8-week-old fetus — are neural stem cells, which have the ability to turn into different types of nerve cells. These are not the same stem cells as the controversial human embryonic stem cells, which destroy the embryo when the stem cells are removed.
Johe says that once the safety of this type of transplant is determined, he and his colleagues hope to see whether this is a possible treatment for ALS.
“This is not a cure. We are not replacing those motor neurons [nerve cells which tell muscles to contract]. These stem cells don’t generate motor neurons. Instead they protect the still-functioning motor neurons,” Johe explained.
Bruijn says that injecting stem cells into the spinal cord — in the region where the motor neurons are located that affect ALS — is a breakthrough. But she cautions that this is only the first step in the first part of this clinical trial. It’s too early to draw any conclusions about the effectiveness of this treatment, especially since the trial has only just begun.
She notes that everyone involved with the study and other ALS patients have to wait and see what the results of the clinical trial will be.
The FDA granted the first approval for injecting human embryonic stem cells into humans to Menlo Park, California-based Geron Corporation in January 2009. Their trials were expected to start last summer but have yet to begin.
As a separate note, who really wants to waste the time building thousands and thousands of followers when none of them are really going to ever pay attention to you? Yes, it’s great to have a high number, but really what is your ultimate reach? How many people are you engaging?
Late last year, I found a couple from the 1950’s and 60’s that were in horrible physical shape that were going to be scrapped for their steel. I got both of them for $10 bucks and did some research on how to refurbish them myself.
I stripped off the corroded, stained, and torn linoleum off the tops, took them to a local place that does sandblasting to have them stripped and then sanded down the heavily rusting portions. (These desks are usually made of heavy 20 gauge solid steel, so they’re literally the “tanks” of office furniture.) Both were in relatively good condition structurally and didn’t have any significant body damage aside from some significant rust, so I decided not to bondo the couple of dings they had, which in the end I think just adds to their vintage beauty.
For the blue/gray one I found an industrial paint shop to do an old style enamel process. For the smaller red one, I sandblasted and painted/sealed the undercarriage and inside drawers and then used a special brushing process to obtain a nice brushed steel effect followed by a 5 layer clear coat seal to give it a high shine while still having the brushed steel visible through the clear coat.
Finally, I tried to find a place to recreate the original linoleum desktops, but there really isnt’ a supplier who does this and some of the alternatives were prohibitively expensive as was the process of redoing the metal trim to hold it on after the fact. I contemplated doing some various laminates and even formica, but ultimately decided that the bare metal top was too pretty to cover up. I finally gave a local glass shop a template for the top of the desk and had them cut out custom 1/4″ glass tops with rounded corners to match the desk shape and then bevel the edges slightly.
At long last they’re now both finished! They are truly beautiful and it’s nice having a desk about the size of a compact car and certainly as heavy! When I originally got the desks, Sonia refused to let me keep them they were in such terrible shape, and I spent a while convincing her to let me keep them. Once the first one was done she forbid me to “hide” it in our office and insisted that I put it in our living room because it was so pretty. I finally got the second one finished and gave it to her for her birthday in September.
It’s been an interesting enough process with such a beautiful end result, that I’m in the midst of acquiring a few additional desks including one that may be from the 30’s/40’s with some nice art deco design touches.
So I suppose I’m calling it my “hobby” at the moment.
I’ve posted a gallery of additional photos of the desks on Flickr.
Degradable quantum channels are among the only channels whose quantum and private classical capacities are known. As such, determining the structure of these channels is a pressing open question in quantum information theory. We give a comprehensive review of what is currently known about the structure of degradable quantum channels, including a number of new results as well as alternate proofs of some known results. In the case of qubits, we provide a complete characterization of all degradable channels with two dimensional output, give a new proof that a qubit channel with two Kraus operators is either degradable or anti-degradable, and present a complete description of anti-degradable unital qubit channels with a new proof. For higher output dimensions we explore the relationship between the output and environment dimensions (dB and dE, respectively) of degradable channels. For several broad classes of channels we show that they can be modeled with an environment that is “small” in the sense of ΦC. Such channels include all those with qubit or qutrit output, those that map some pure state to an output with full rank, and all those which can be represented using simultaneously diagonal Kraus operators, even in a non-orthogonal basis. Perhaps surprisingly, we also present examples of degradable channels with “large” environments, in the sense that the minimal dimension dE>dB. Indeed, one can have dE>14d2B. These examples can also be used to give a negative answer to the question of whether additivity of the coherent information is helpful for establishing additivity for the Holevo capacity of a pair of channels. In the case of channels with diagonal Kraus operators, we describe the subclasses that are complements of entanglement breaking channels. We also obtain a number of results for channels in the convex hull of conjugations with generalized Pauli matrices. However, a number of open questions remain about these channels and the more general case of random unitary channels.
Dates: September 13-14, 2008; 10am - 6pm, both days Los Angeles Convention Center, 1201 South Figueroa Street Los Angeles, California 90015 Still FREE Registration is Open until September 10th, 2008. Please visit our official site for more details and to sign up!
Microscopy, phenotyping and visual screens are frequently applied to model organisms in combination with genetics. Although widely used, these techniques for multicellular organisms have mostly remained manual and low-throughput. Here we report the complete automation of sample handling, high-resolution microscopy, phenotyping and sorting of Caenorhabditis elegans. The engineered microfluidic system, coupled with customized software, has enabled high-throughput, high-resolution microscopy and sorting with no human intervention and may be combined with any microscopy setup. The microchip is capable of robust local temperature control, self-regulated sample-loading and automatic sample-positioning, while the integrated software performs imaging and classification of worms based on morphological and intensity features. We demonstrate the ability to perform sensitive and quantitative screens based on cellular and subcellular phenotypes with over 95% accuracy per round and a rate of several hundred worms per hour. Screening time can be reduced by orders of magnitude; moreover, screening is completely automated.
Previously reported better fertilization rate after intracytoplasmic single sperm injection (ICSI) than after subzonal insemination of several spermatozoa was confirmed in a controlled comparison of the two procedures in 11 patients. Intracytoplasmic sperm injection was carried out in 150 consecutive treatment cycles of 150 infertile couples, who had failed to have fertilized oocytes after standard in-vitro fertilization (IVF) procedures or who were not accepted for IVF because not enough motile spermatozoa were present in the ejaculate. A single spermatozoon was injected into the ooplasm of 1409 metaphase II oocytes. Only 117 oocytes (8.3%) were damaged by the procedure and 830 oocytes (64.2% of the successfully injected oocytes) had two distinct pronuclei the morning after the injection procedure. The fertilization rate was not influenced by semen characteristics. After 24 h of further in-vitro culture, 71.2% of these oocytes developed into embryos, which were transferred or cryopreserved. Only 15 patients did not have embryos replaced. Three-quarters of the transfers were triple-embryo transfers. High pregnancy rates were noticed since 67 pregnancies were achieved, of which 53 were clinical, i.e. a total and clinical pregnancy rate of 44.7% and 35.3% per started cycle and 49.6% and 39.2% per embryo transfer. A total of 237 supernumerary embryos were cryopreserved in 71 treatment cycles.
Originally published in 1969. This book explains what is wrong with the traditional methodology of “inductive” reasoning and shows that the alternative scheme of reasoning associated with Whewell, Pierce and Popper can give the scientist a useful insight into the way he thinks.
- History of the Inductive Sciences by William Whewell (1837)
- Introduction à l’étude de la médecine expérimentale by Claude Bernard (Paris, 1865)
- Karl Popper
- Karl Pearson (math)
This is certainly worth the read for the high qualities of its translation and vocabulary. There are lots of great aphorisms and brilliant bits of advice. Some of the parts about patriotism and information about things like picking a wife are anachronistically funny to read 100+ years after they were written.
In a talk aimed at the general public, Professor Hawking discusses theories on the origin of the universe. He explains how time can have a beginning, and addresses the progress made by cosmologists in an area which has traditionally belonged to theologists and philosophers.
Stephen Hawking holds the prestigious Lucasian chair at Cambridge University, once held by Sir Isaac Newton. He is one of the early developers of the theory of black holes and author of the international best-selling book A Brief History of Time.
PLEASE NOTE: This event is free, but tickets will be required. General admission tickets will be distributed on the morning of the lecture only. Please carefully review the complete ticketing procedures, available in a PDF file here.
Tuesday, April 4, 2006
8:00pm to 10:00pm
Scientific knowledge grows at a phenomenal pace--but few books have had as lasting an impact or played as important a role in our modern world as The Mathematical Theory of Communication, published originally as a paper on communication theory in the Bell System Technical Journal more than fifty years ago. Republished in book form shortly thereafter, it has since gone through four hardcover and sixteen paperback printings. It is a revolutionary work, astounding in its foresight and contemporaneity. The University of Illinois Press is pleased and honored to issue this commemorative reprinting of a classic.