June 17-21, 2019
This workshop will tackle a variety of biological and medical questions using mathematical models to understand complex system dynamics. Working in collaborative teams of 6, each with a senior research mentor, participants will spend a week making significant progress with a research project and foster innovation in the application of mathematical, statistical, and computational methods in the resolution of problems in the biosciences. By matching senior research mentors with junior mathematicians, the workshop will expand and support the community of scholars in mathematical biosciences. In addition to the modeling goals, an aim of this workshop is to foster research collaboration among women in mathematical biology. Results from the workshop will be published in a peer-reviewed volume, highlighting the contributions of the newly-formed groups. Previous workshops in this series have occurred at IMA, NIMBioS, and MBI.
This workshop will have a special format designed to facilitate effective collaborations.
- Each senior group leader will present a problem and lead a research group.
- Group leaders will work with a more junior co-leader, someone with whom they do not have a long-standing collaboration, but who has enough experience to take on a leadership role.
- Additional team members will be chosen from applicants and invitees. We anticipate a total of five or six people per group.
It is expected that each group will continue to work on their project together after the workshop, and that they will submit results to the Proceedings volume for the workshop.
The benefit of such a structured program with leaders, projects and working groups planned in advance is based on the successful WIN, Women In Numbers, conferences and is intended to provide vertically integrated mentoring: senior women will meet, mentor, and collaborate with the brightest young women in their field on a part of their research agenda of their choosing, and junior women and graduate students will develop their network of colleagues and supporters and encounter important new research areas to work in, thereby fostering a successful research career. This workshop is partially supported by NSF-HRD 1500481 – AWM ADVANCE grant.
ORGANIZING COMMITTEERebecca Segal (Virginia Commonwealth University)
Blerta Shtylla (Pomona College)
Suzanne Sindi (University of California, Merced)
When: Wednesday, October 25, 2017, from 4:30 PM – 6:30 PM PDT Where: UCLA California NanoSystems Institute (CNSI), 570 Westwood Plaza, Los Angeles, CA 90095 While there is no mathematical formula for writing television comedy, for the writers of The Simpsons, Futurama, and The Big Bang Theory, mathematical formulas (along with classic equations and cutting-edge theorems) can sometimes be an integral part of those shows. In a lively and nerdy discussion, five of these writers (who have advanced degrees in math, physics, and computer science) will share their love of numbers and talent for producing laughter. Mathematician Sarah Greenwald, who teaches and writes about math in popular culture, will moderate the panel. The event will begin with a lecture by bestselling author Simon Singh (The Simpsons and Their Mathematical Secrets), who will examine some of the mathematical nuggets hidden in The Simpsons (from Euler’s identity to Mersenne primes) and discuss how Futurama has also managed to include obscure number theory and complex ideas about geometry. Tickets: Tickets are $15 each and seating is limited, so reserve your seat soon. Tickets can be purchased here via Eventbrite (ticket required for entry to the event). A limited number of free tickets will be reserved for UCLA students. We ask that students come to IPAM between 9:00am and 3:00pm on Friday, October 20, to present your BruinCard and pick up your ticket (one ticket per BruinCard, nontransferable). If any tickets remain, we will continue distributing free tickets to students on Monday, Oct. 23, starting at 9:00am until we run out. Both your ticket and BruinCard must be presented at the door for entry. Doors open at 4:00. Please plan to arrive early to check in and find a seat. We expect a large audience.
The hard core math crowd may be disappointed in the level, but it could be an interesting group to get out and be social with.
My review of The Simpsons and Their Mathematical Secrets from Goodreads:
I’m both a math junkie and fan of the Simpsons. Singh’s book is generally excellent and well written and covers a broad range of mathematical areas. I’m a major fan of his book Big Bang: The Origin of the Universe, but find myself wanting much more from this effort. Much of my problem stems from my very deep knowledge of math and its history as well as having read most of the vignettes covered here in other general popular texts multiple times. Fortunately most readers won’t suffer from this and will hopefully find some interesting tidbits both about the Simpsons and math here to whet their appetites.
There were several spots at which I felt that Singh stretched a bit too far in attempting to tie the Simpsons to “mathematics” and possibly worse, several spots where he took deliberate detours into tangential subjects that had absolutely no relation to the Simpsons, but these are ultimately good for the broader public reading what may be the only math-related book they pick up this decade.
@lpachter Your cup of tea over at UCLA next week? Regulatory & Epigenetic Stochasticity in Development & Disease http://www.ipam.ucla.edu/programs/workshops/regulatory-and-epigenetic-stochasticity-in-development-and-disease
Epigenetics refers to information transmitted during cell division other than the DNA sequence per se, and it is the language that distinguishes stem cells from somatic cells, one organ from another, and even identical twins from each other. In contrast to the DNA sequence, the epigenome is relatively susceptible to modification by the environment as well as stochastic perturbations over time, adding to phenotypic diversity in the population. Despite its strong ties to the environment, epigenetics has never been well reconciled to evolutionary thinking, and in fact there is now strong evidence against the transmission of so-called “epi-alleles,” i.e. epigenetic modifications that pass through the germline.
However, genetic variants that regulate stochastic fluctuation of gene expression and phenotypes in the offspring appear to be transmitted as an epigenetic or even Lamarckian trait. Furthermore, even the normal process of cellular differentiation from a single cell to a complex organism is not understood well from a mathematical point of view. There is increasingly strong evidence that stem cells are highly heterogeneous and in fact stochasticity is necessary for pluripotency. This process appears to be tightly regulated through the epigenome in development. Moreover, in these biological contexts, “stochasticity” is hardly synonymous with “noise”, which often refers to variation which obscures a “true signal” (e.g., measurement error) or which is structural, as in physics (e.g., quantum noise). In contrast, “stochastic regulation” refers to purposeful, programmed variation; the fluctuations are random but there is no true signal to mask.
This workshop will serve as a forum for scientists and engineers with an interest in computational biology to explore the role of stochasticity in regulation, development and evolution, and its epigenetic basis. Just as thinking about stochasticity was transformative in physics and in some areas of biology, it promises to fundamentally transform modern genetics and help to explain phase transitions such as differentiation and cancer.
This workshop will include a poster session; a request for poster titles will be sent to registered participants in advance of the workshop.
Adam Arkin (Lawrence Berkeley Laboratory)
Gábor Balázsi (SUNY Stony Brook)
Domitilla Del Vecchio (Massachusetts Institute of Technology)
Michael Elowitz (California Institute of Technology)
Andrew Feinberg (Johns Hopkins University)
Don Geman (Johns Hopkins University)
Anita Göndör (Karolinska Institutet)
John Goutsias (Johns Hopkins University)
Garrett Jenkinson (Johns Hopkins University)
Andre Levchenko (Yale University)
Olgica Milenkovic (University of Illinois)
Johan Paulsson (Harvard University)
Leor Weinberger (University of California, San Francisco (UCSF))
The equations of gauge theory lie at the heart of our understanding of particle physics. The Standard Model, which describes the electromagnetic, weak, and strong forces, is based on the Yang-Mills equations. Starting with the work of Donaldson in the 1980s, gauge theory has also been successfully applied in other areas of pure mathematics, such as low dimensional topology, symplectic geometry, and algebraic geometry.
More recently, Witten proposed a gauge-theoretic interpretation of Khovanov homology, a knot invariant whose origins lie in representation theory. Khovanov homology is a “categorification” of the celebrated Jones polynomial, in the sense that its Euler characteristic recovers this polynomial. At the moment, Khovanov homology is only defined for knots in the three-sphere, but Witten’s proposal holds the promise of generalizations to other three-manifolds, and perhaps of producing new invariants of four-manifolds.
This workshop will bring together researchers from several different fields (theoretical physics, mathematical gauge theory, topology, analysis / PDE, representation theory, symplectic geometry, and algebraic geometry), and thus help facilitate connections between these areas. The common focus will be to understand Khovanov homology and related invariants through the lens of gauge theory.
This workshop will include a poster session; a request for posters will be sent to registered participants in advance of the workshop.
March 6, 2017
From Gauge Theory to Khovanov Homology Via Floer Theory
The goal of the lecture is to describe a gauge theory approach to Khovanov homology of knots, in particular, to motivate the relevant gauge theory equations in a way that does not require too much physics background. I will give a gauge theory perspective on the construction of singly-graded Khovanov homology by Abouzaid and Smith.
March 8, 2017
An Introduction to the SYK Model
The Sachdev-Ye model was originally a model of quantum spin liquids that was introduced in the mid-1990′s. In recent years, it has been reinterpreted by Kitaev as a model of quantum chaos and black holes. This lecture will be primarily a gentle introduction to the SYK model, though I will also describe a few more recent results.