Dates: September 13-14, 2008; 10am - 6pm, both days
Los Angeles Convention Center, 1201 South Figueroa Street Los Angeles, California 90015
Registration is Open until September 10th, 2008. Please visit our official site for more details and to sign up!
Microscopy, phenotyping and visual screens are frequently applied to model organisms in combination with genetics. Although widely used, these techniques for multicellular organisms have mostly remained manual and low-throughput. Here we report the complete automation of sample handling, high-resolution microscopy, phenotyping and sorting of Caenorhabditis elegans. The engineered microfluidic system, coupled with customized software, has enabled high-throughput, high-resolution microscopy and sorting with no human intervention and may be combined with any microscopy setup. The microchip is capable of robust local temperature control, self-regulated sample-loading and automatic sample-positioning, while the integrated software performs imaging and classification of worms based on morphological and intensity features. We demonstrate the ability to perform sensitive and quantitative screens based on cellular and subcellular phenotypes with over 95% accuracy per round and a rate of several hundred worms per hour. Screening time can be reduced by orders of magnitude; moreover, screening is completely automated.
Previously reported better fertilization rate after intracytoplasmic single sperm injection (ICSI) than after subzonal insemination of several spermatozoa was confirmed in a controlled comparison of the two procedures in 11 patients. Intracytoplasmic sperm injection was carried out in 150 consecutive treatment cycles of 150 infertile couples, who had failed to have fertilized oocytes after standard in-vitro fertilization (IVF) procedures or who were not accepted for IVF because not enough motile spermatozoa were present in the ejaculate. A single spermatozoon was injected into the ooplasm of 1409 metaphase II oocytes. Only 117 oocytes (8.3%) were damaged by the procedure and 830 oocytes (64.2% of the successfully injected oocytes) had two distinct pronuclei the morning after the injection procedure. The fertilization rate was not influenced by semen characteristics. After 24 h of further in-vitro culture, 71.2% of these oocytes developed into embryos, which were transferred or cryopreserved. Only 15 patients did not have embryos replaced. Three-quarters of the transfers were triple-embryo transfers. High pregnancy rates were noticed since 67 pregnancies were achieved, of which 53 were clinical, i.e. a total and clinical pregnancy rate of 44.7% and 35.3% per started cycle and 49.6% and 39.2% per embryo transfer. A total of 237 supernumerary embryos were cryopreserved in 71 treatment cycles.
Finished reading Induction and Intuition in Scientific Thought by P.B. Medawar
Originally published in 1969. This book explains what is wrong with the traditional methodology of “inductive” reasoning and shows that the alternative scheme of reasoning associated with Whewell, Pierce and Popper can give the scientist a useful insight into the way he thinks.
This is certainly worth the read for the high qualities of its translation and vocabulary. There are lots of great aphorisms and brilliant bits of advice. Some of the parts about patriotism and information about things like picking a wife are anachronistically funny to read 100+ years after they were written.
In a talk aimed at the general public, Professor Hawking discusses theories on the origin of the universe. He explains how time can have a beginning, and addresses the progress made by cosmologists in an area which has traditionally belonged to theologists and philosophers.
Stephen Hawking holds the prestigious Lucasian chair at Cambridge University, once held by Sir Isaac Newton. He is one of the early developers of the theory of black holes and author of the international best-selling book A Brief History of Time.
PLEASE NOTE:This event is free, but tickets will be required. General admission tickets will be distributed on the morning of the lecture only. Please carefully review the complete ticketing procedures, available in a PDF file here.
Tuesday, April 4, 2006
8:00pm to 10:00pm
Arrived around 7:15 to get in line and ended up with a nice seat about 10 rows back from the stage. He was entertaining and even a tad inspirational, but it was definitely a “public” lecture and disappointingly had absolutely no technical content in the least.
Scientific knowledge grows at a phenomenal pace--but few books have had as lasting an impact or played as important a role in our modern world as The Mathematical Theory of Communication, published originally as a paper on communication theory in the Bell System Technical Journal more than fifty years ago. Republished in book form shortly thereafter, it has since gone through four hardcover and sixteen paperback printings. It is a revolutionary work, astounding in its foresight and contemporaneity. The University of Illinois Press is pleased and honored to issue this commemorative reprinting of a classic.
Christopher J. Aldrich, Engr ’96, of Los Angeles, writes:
“I recently booked Bea Arthur into two episodes of the TV show “Malcolm in the Middle,” for which she received an Emmy nomination. Following this, I left Creative Artists Agency to join David Entertainment, where I helped to produce MGM’s Breakers, starring Sigourney Weaver and Jennifer Love Hewitt. Now I’m preparing for production of Doctor Doolittle 2, starring Eddie Murphy and Behind Enemy Lines, with Gene Hackman and Owen Wilson.”
GOOD MORNING: Sunday morning, hours after they departed the SRO BevHilton ballroom where their Carousel of Hope Ball raised more than $6 million ($1.5 million from Marvin) benefiting the Children’s Diabetes Foundation, Marvin and Barbara Davis were hosting a lavish lunch for the out-of-town guests plus participants in the fundraiser. Marvin still couldn’t get over the ball’s finale when he saw wife Barbara on stage shaking it with Ricky Martin — who had the entire ballroom on its feet dancing. Barbara had also told Michael Jackson, “Ricky wants to meet you.” So Jackson and his date Elizabeth Taylor made their way backstage with Barbara, who shoved Michael onstage for a brief moment in the spotlight with the new king, Ricky Martin. Martin had flown in from Australia with his entire troupe to perform gratis, as did the other artists. I had been annoyed by Jackson and Taylor, who were sitting directly in front of our table. I thought them rude as they engaged in conversation during Ricky’s first two numbers. Jackson’s doctor, dermatologist Arnold Klein; had sidled up to talk with them during Martin’s performance. (Klein’s nurse Debbie Rowe, you recall, married/divorced Michael and bore him two children: son Prince, 3-1/2, and daughter Paris, 2-1/2). Jackson and his children have been regular (biweekly) visitors at the Davis’ home and the offspring get high marks from Marvin. John Davis had birthday-gifted dad Marvin with two tiny donkeys which graze on the lush lawn; the celeb lunch bunch had a full view of the tiny critters who have free rein (and you know what that includes) of the garden … At the BevHilton, Elizabeth and Michael were seated at one end of the head table on the first riser and in full view of the crowd below. As you might imagine, their presence created a major crush of visitors; some like Shirley MacLaine and Carrie Fisher (who just toiled with Taylor in “Those Old Broads”) carried on their conversation on the carpeting alongside Elizabeth. Another of the “Broads,” Joan Collins, was seated elsewhere with Evie and Leslie Bricusse. Collins is off to England to be at daughter Tara Newley’s side during her divorce battle. Joan is no stranger to that stage.
IT WAS NO SECRET that Ricky Martin, while the toast of the (young) world, was nervous about appearing before this mature, star-studded audience of performers and execs. He needn’t have been! Sure, he’s had movie offers but can’t accept because of the time they’d take away from his concerts and recordings. He winged out (in his plane) immediately after the BevHilton benefit to Miami … Performers at future BevHilton events will be pleased to know that Merv Griffin, the Carousel Ball’s host, has built a new backstage facility for talent. It was appreciated by the magnificent performers Toni Braxton (who said her mother has diabetes), young Charlotte Church (whatta voice!), David Foster and the musicians. Jay Leno’s takeoff tape on candidates Gore and Bush was classic, but his remarks about President Clinton are getting to be overdone by now. Touching moments were the remarks by Barbara Davis, daughter Dana (and the presentation of a hand receiving the brass ring sculpture) and Sidney Poitier. George Schlatter did a terrif job again producing the show … Clive Davis, one of the music chairmen, just signed Luther Vandross and O-Town to his new J Records and has now added a young duo from Brazil: Medeiros, brothers Julian and Rodalgo M. who sing in Portuguese, Spanish and English. Attending with Davis was his cousin Jo Schuman Silver, owner of SanFran’s fantastic “Beach Blanket Babylon” show, which continues SRO for every performance … Among those who stopped by to hug Michael Jackson was Berry Gordy, his discoverer. Also Suzanne De Passe. Also there Keely Shaye Smith and Pierce Brosnan, who told me he doesn’t expect to be away at work when their baby arrives in February. And they probably will not have the wedding until summer, in Ireland … As always, the Carousel Ball featured a silent auction which preceded in the BevHilton’s rooms surrounding the lobby and ballroom. Dana Davis and sister Nancy Davis-Rickel again chaired and the auction brought in $623,389 — to date. They are still selling items. Celebrity-designed plates brought in $56,700. Guests included Line Renaud, just in from Paris. She arrived with Veronique and Gregory Peck (he contributed one of the designed plates). Neil Diamond even bought a painting by LeRoy Neiman, which he had contributed … Marvin Davis, whose properties over the years have included 20th Century Fox and the Beverly Hills Hotel, has a new affiliation with Lend Lease with plans to build everything “all over the world.” Meanwhile the Davises continue to build to one day find a cure for childhood diabetes.
AND NOW, AS THEY SAY on the 11 o’clock news, “some late-breaking news”: Charlton Heston, who starred in the first two “Planet of the Apes” pix for 20th, will cameo in the next. Yes, he was killed off in the second pic — but now he returns as an ape. No, he’s not a foot soldier, so he won’t have to carry a gun — as I did, as an ape (member of the National Rhesus Assn., ya know) in the first “Planet” pic, opposite Heston. Producer Richard Zanuck and director Tim Burton launch next week in Paige, Ariz., site of the first.
It’s all about the donkeys:
John Davis had birthday-gifted dad Marvin with two tiny donkeys which graze on the lush lawn; the celeb lunch bunch had a full view of the tiny critters who have free rein (and you know what that includes) of the garden …
Class of 1996:
JEFFREY P. DOSHNA and SARAH (WATSON) DOSHNA write: "We are pleased to announce the birth of our son, Noah Alexander Doshna on April 29. Sarah continues to work as a process engineer for Merck & Co., in their sterile pilot plants. Although Jeff is continuing his doctoral studies in the department of urban planning at Rutgers University, he has assumed the role of 'stay-at-home' dad for the time being. Fellow Vincent-Willard alumna IVY WONG '96, paid a visit in June and brought a card for Noah signed by ROGER OEN '96, JAMES ARMSTRONG '94, CHRIS ALDRICH '96, MAX BARTEAU '96, TAMMY WU '96, JANET LEE '96, PETER SYLVES '96, and TONY TSAI '96. We also regularly see JOHN PAXTON '96."
8/8/2018: I’m collecting some snippet mentions of me from the early days of the web. Notes like this online (and also in print at the time) were the original social networking.
More than 400 guests attended Johns Hopkins convocations in San Francisco and Burbank in March, hearing from President William R. Brody and other outstanding faculty speakers about developments at Johns Hopkins. The Southern California convocation, held at the Walt Disney Studios, was hosted by University trustee John F. Cooke, Disney's executive vice president-corporate affairs.
Address of George Bush
41st President of the United States
The Johns Hopkins University
Arts and Sciences/Engineering Undergraduate Diploma Award Ceremony
Baltimore, Maryland -- May 22 1996 (verbatim transcript)
Madam President, thank you for that wonderful, warm introduction and what a pleasure it was to meet with Asma and the other leaders of this class here today. I felt very relieved when I told them that I was going to give this speech on the gold standard and the international balance of payments. It only takes about 50 minutes and they all seemed enthralled with the idea. All of which reminded me, as I was telling Dr. Nathans and my friend, Mike Bloomberg, who's taken on the chairmanship of the board here, about a graduation at Yale University which I attended, and the speaker went on. He went Y is for Youth, he went on about 25 minutes, A for Altruism, another 35 minutes, L for Loyalty, 30 minutes, E for Excellence. By the time he finished, all but one kid had left. The guy was praying. He said, "Oh son, I'm so pleased to see you here giving thanks." He said, "What exactly are you praying for?" The kid said, "Well, I'm praying that I did not ... thanks to the Lord that I did not go to Johns Hopkins University."
Um, I'm pleased to be here. It's been a little more that six years since I visited this prestigious university for Commemoration Day. And I am delighted to be back here. I salute Dr. Nathans for what he has given to this university, not only as faculty but as his interim period as president and I am grateful for his service to the country on our Science Board which he served ... with no partiality, but just bringing to the board his sense of excellence for which Johns Hopkins is so famous. It doesn't seem possible that 48 years ago I was sitting out there where our graduates are today, most of them, bursting to get out there and claim my stake in the world, to try anything. And I am sure that each of you feels the same way, and I encourage you to do it all. Don't be afraid of trying, of dreaming. Don't even be afraid of failure or tears. We all stumble. We all face fear, and that's what makes us human. But none of us should ever regret, none of us should ever sit at a grandchild's graduation and think, I wish that that were me, starting all over again, there's so much I'd do differently. First of all, don't worry, any of you graduates, if you're not 100 percent sure what you want to do the rest of your life, what you want to be 30 years from now. Barbara and I have lived in about 40 different houses, over the course of 51 years of marriage, and I wish Barbara would stop saying, "George can't hold a job." But, uh, but it was only after a couple of decades out in the real world that I knew what I wanted to do with the rest of my life. But the point is this, you have a lifetime of chances in your grasp right now. Don't lose any of them. Don't give up the chance to take a risk, follow a vision, hug a child, touch a life.
Touching a life. That's what I want to talk to you about today. Each of you has visions of success for your future. You can just feel the energy as the president spoke here, what a wonderful job she did. Find your own ways to define it. Let me give you mine. As often I said as president, I believe that any definition of a successful life must include service to others. It's just that simple. It doesn't mean that you have to run for public office, but I hope all of you will somehow save some time to be actively involved in our political system. It's not very pleasant in the political arena these days. There's an adversarial press, and a very, very much, kind of a controversial environment. But it's worth it. It's worth it to get into what Teddy Roosevelt calls the arena, roll up your sleeves and try. Serving others does mean rolling up your sleeves and getting involved in your community, though. It means getting off the sidelines, it means being a doer and not a critic. It means contributing to a cause larger than yourself. There is no problem. You know you read the papers, there's all these problems. But there is not one single problem in the country today that somewhere is not being solved by some people. And for eight years as vice president and four as president and even today unemployed and retired, I have seen literally thousands of examples of the neighbor-helping-neighbor spirit that made this country the kindest and the gentlest and the strongest in the entire world. It was one of the real joys of being president, and Barbara and I are continuing to try and encourage others to volunteer their time and effort to fighting a community problem. People say, "What's it like from going from being president of the United States of America one day" ... they don't say to be unemployed the next, they're very polite to us now. We can even go to a ballgame in Camden Yards and not even get booed. It's wonderful. But they say, "What's it like," "What's it like?" and it's a wonderful life, because what we want to do is what everybody on this faculty, I'm sure, does; what every parent does; and that's put something back into the system. Give something to the community in one way or another. It doesn't have to be dramatic, it doesn't have to be in the newspapers, some way to have the satisfaction of knowing you're helping make somebody else's life a little brighter. Of course, government has an obligation to help those who cannot help themselves. And yet there's something special about the kindness of a neighbor helping someone he or she doesn't know. It gives that special touch that is beyond the power of government to provide. No exercise is better for the human heart than reaching down and lifting someone else up, and to serve others, to enrich your community. This truly defines a successful life. For success is personal, and it is charitable, and it is the sum, not of our possessions, but of how we help others.
And so, here I am at 72 years old, and I'm expected to give advice, and I will. My advice is to encourage you to follow the example of those who have preceded you and to set an example for those who follow. For each of you, Johns Hopkins has been a wonderful place of possibilities. This standard of excellence has been for each of you a place of possibilities. A place where you have developed your potential and prepared for the future. But now the time has come to venture out. The time has arrived for you to put in the hard work and the sacrifice and dedication that transforms these possibilities into reality.
Do it all, but do it without neglect of family. People say to me, "What's the largest problem, what's your biggest shortcoming?" The largest problem is, in my view, facing the country is the decline or the weakening of the American family and my biggest shortcoming was not being able to rally the country, not for government legislation, but to do something to strengthen the American family. And so each of you, your career paths ahead of you, do something to help strengthen the family and for those kids that don't have a family, take them under your wing and help them, too.
Let me close. I am an optimist about the future. I honestly and truly believe that our best days are yet to come. I believe this because I've seen how far we've come. Gone are the suspicions and the conflict of the Cold War. We no longer face threat of nuclear holocaust, where your parents, some of them, were taught to hide under their desks, to avoid nuclear fallout. We no longer live in a world of two antagonistic superpowers, and, as for me, I take heart that a teacher will not have to explain balance of terror, mutually assured destruction, and all of these other acronyms of the Cold War. We're putting that dark chapter behind us and today the world is rife with promise and opportunity, and yes, cliche though it may be, today begins the rest of your life. A Yale teacher once said, "Whatever you can do or dream you can do, begin it, for today has power, boldness and magic in it.
My favorite story was told by a great friend of Barbara's and mine who received the congressional gold medal the other day, the coveted award, Billy Graham. And he told about a speaker that was standing where I am and the speaker went on too long, so one of the guys at the head table, the dais, picked up his shoe, heaved it at him, missed him and hit a lady sitting in the front row. She goes like this and says, "Hit me again. I can still hear him."
So I would say to you, be bold in your dreaming, be bold in your living, be bold in your caring, your compassion, your humanity and then, when you sit at your grandchild's commencement half a century from now, you'll look back at the tapestry of your life and find it good, and that will be the greatest success of all.
Thank you for welcoming me back to this very special campus and may God bless every single graduate in the class of 1996. Thank you very much!
The student-run SNARK film series will screen a sneak
preview of the soon-to-be-released Michael Douglas-Annette Bening
film, American President, in the newly refurbished Shriver Hall
Theater at 7:30 p.m. on Tuesday, Nov. 14. The auditorium, which
seats 1,100, was recently outfitted with a new screen, 35-mm
projectors and soon-to-be-installed Dolby sound system in part to
accommodate student organizations, which promised to bring to
Homewood sneak previews of major Hollywood films.
SNARK director Chris Aldrich says the free tickets are
available at the Levering Hall Student Union desk beginning at
MSE Symposium Unspools Tuesday at Shriver Hall
At 100, Why Do Movies Matter?
Special to The Gazette
Not that turf-conscious professors need worry about one of the main campus buildings being converted into a nine-screen multiplex theater, but the movies have arrived on the Homewood campus in a big way.
Most immediately, the Milton S. Eisenhower Symposium, "Framing Society: A Century of Cinema," opens this week to examine the roles of the motion pictures in American society. Its undergraduate co-chairmen, Matt Gross and Chris Aldrich, are no strangers to the subject of film. Each is involved in film classes, student film organizations, film production, screenings and a just-launched magazine. All of which, considered together with the symposium, they hope will provide a new frame of reference at Hopkins for the only art form that proceeds at 24 frames per second.
Lest anyone still harbor the prejudice that movies should be accompanied by popcorn and not term papers, young filmmaker Gross is quick to defend the academic worth of their symposium offering.
"Chris and I always felt it was an appropriate topic for the symposium," he says. "It wasn't so much deciding whether to do it as how to do it. We want to explore how cinema fits into our culture. Can a particular movie or stream of movies change things in society?"
By way of example, he dips into film and political history for the famous anecdote about President Woodrow Wilson's proclamation that D.W. Griffith's controversial 1915 film Birth of a Nation was "like history written by lightning."
Gross says, "It's a historical fact that Wilson was one of the first people to give legitimacy to film. Since he went to Hopkins, he's like this guy sitting on top of the ivory tower saying this is a way of reporting history. That legitimizes film as a historical pursuit. And the 100th anniversary of cinema is an opportunity to look back on film in a cultural and intellectual way."
Gross adds that a visit to Paris reinforced his sense that the French, whose visionary Lumière brothers began showing movies commercially in 1895, have a much keener sense of film history than do Americans.
"It's not just that Americans don't have a grasp of film history. There's not a good grasp of history among the American people," he says.
There's yet another reason why Gross believes movies haven't always received the respect they deserve in this country.
"Also, possibly, the business of film has gotten in the way somewhat," he says. "Because it is big business--it's a product--some people may not feel it's worth looking at" in an academic forum, he says.
Gross looks on this year's symposium as a springboard for a broader discussion, both on campus and in the larger community, of the role played by movies.
"The symposium is a way to get everybody who is interested together in one place to talk about movies. Beyond the symposium, we're trying to create at Hopkins a kind of cinematic culture. And we need to expand so that the Baltimore public knows about what's at Hopkins," Gross says. "Being on campus for four years, everything feels so isolated. Many students know a lot about film but not always about what's going on off campus, and people off campus in Baltimore know about film but not about what we have here.
"We'd like to integrate Hopkins into the Baltimore community at large. We want to be a regular part of the movie scene. So we want the symposium to act as a catalyst for everything else," he says.
One impact the symposium will have on and off campus will result from the outfitting of Shriver Hall with a new 38-foot screen.
"The old screen had been subjected to The Rocky Horror Picture Show and other things," says Mary Ellen Porter, special assistant to dean of students Larry Benedict. The film is noted as much for its campy content as for its cult following, who make viewing the film an interactive experience replete with vegetables and other substances tossed at the screen.
Also added were 35mm film projectors, and there are plans to add "surround sound" equipment next year. These technical enhancements will make the 1,174-seat hall the largest and potentially one of the best movie theaters in the Baltimore area.
Existing film series such as the long-running Reel World and Weekend Wonderflix will look better on screen. Porter says the booking of preview screenings and other special programs "will give us a chance to reach out to the greater community in a way we don't now."
Better campus screening facilities can enhance both a weekend date for the latest Die Hard movie and a student taking notes on the mise-en-scène in a Renoir film.
"In terms of facilities, film is a machine art and machines are a part of it," notes Richard Macksey, a longtime Hopkins professor of humanities and film and an active member of Baltimore's cinema culture. He cites the upgrading of 110 Gilman several years ago as an instance of how film courses prosper when projection moves closer to state of the art.
Indeed, the cinematic zeitgeist on campus seems healthy. Last summer saw the birth of yet another film series, The Snark, which offers classics and avant-garde fare. Also recently arrived on the screen scene is the Animation Club.
The recently established Johns Hopkins Film Society and its magazine, Frame of Reference, promote film culture at Hopkins, including criticism, theory, history and production. Mardi Gras Baltimore, co-directed by Gross and 1995 graduate Gil Jawetz, will premiere at the symposium at 8 p.m. on Nov. 15.
Gross hopes the diversity of symposium speakers will provide the insights and inspiration to support and nourish the
confluence of Hopkins' film-related activities.
For example, James G. Robinson, founder and CEO of Morgan Creek Productions, will talk about the business of making movies. Veteran screenwriter Millard Kaufman and young director Rose Troche will each talk about their place within that industry. Critic Molly Haskell will talk about the role played by women in filmmaking and criticism. And Thomas Cripps, among the world's leading scholars of black film history, will add his reflections on the representation of blacks in the movies and the social effects of those images.
It's a lineup that has won over at least one initial skeptic.
"Frankly, I was a little skeptical of it at first because a lot of money goes into [the symposium], and I didn't want to see speakers who'd stand up there schmoozing and then vanish into the night," says English professor Jerome Christensen, who directs the Film and Media Studies program.
Established in 1991, Film and Media Studies is a cooperative program of the departments of English, French, German, Hispanic and Italian Studies, Writing Seminars, Humanities and Philosophy. Presently, students may minor in this area, but Christensen expects that the eventual addition of a film production course will enable students to major in Film and Media Studies. Although he says Hopkins "will never be a film school" on the scale of New York University or the University of Southern California, it is taking its place with other academic pursuits at Homewood.
"I'm glad [Gross and Aldrich] have used [the symposium] in a way that will be educational," Christensen says. "I'm hoping the symposium will demonstrate the range of opportunities both in terms of careers and the intellectual challenges that contemporary film represents. It also gives us a push to do other things."
Christensen suggests the symposium visit of Indian filmmaker Girish Karnad will likely figure into classroom discussions in a course on Indian film being offered in the spring. Undergraduate internships with Robinson also are under discussion.
"My aim is to have some institutional pay-off to these things," he says.
"Film is especially adaptable to an interdisciplinary approach and it's used for so many pedagogical purposes now," says Macksey of the Hopkins approach to teaching film. Having mentored such future Hollywood talents as Walter Murch and Caleb Deschanel during their student days in the 1960s, Macksey has been a constant advocate for film studies on campus.
And what would the students like to see on the classroom screen scene in the semesters ahead?
"I'd like to consider how the film study is done at New York University, Columbia, USC and elsewhere and then find a different and original way to go at it at Hopkins," Gross says. "Many of those film schools examine how movies are made and not as much attention is paid to movies as literature. That's something Hopkins can do."