In the mathematical field of graph theory, the Erdős–Rényi model is either of two closely related models for generating random graphs. They are named after mathematicians Paul Erdős and Alfréd Rényi, who first introduced one of the models in 1959,[1][2] while Edgar Gilbert introduced the other model contemporaneously and independently of Erdős and Rényi.[3] In the model of Erdős and Rényi, all graphs on a fixed vertex set with a fixed number of edges are equally likely; in the model introduced by Gilbert, each edge has a fixed probability of being present or absent, independently of the other edges. These models can be used in the probabilistic method to prove the existence of graphs satisfying various properties, or to provide a rigorous definition of what it means for a property to hold for almost all graphs.

Networks of coupled dynamical systems have been used to model biological oscillators1–4, Josephson junction arrays5,6, excitable media7, neural networks8–10, spatial games11, genetic control networks12 and many other self-organizing systems. Ordinarily, the connection topology is assumed to be either completely regular or completely random. But many biological, technological and social networks lie somewhere between these two extremes. Here we explore simple models of networks that can be tuned through this middle ground: regular networks ‘rewired’ to introduce increasing amounts of disorder. We find that these systems can be highly clustered, like regular lattices, yet have small characteristic path lengths, like random graphs. We call them ‘small-world’ networks, by analogy with the small-world phenomenon13,14 (popularly known as six degrees of separation15). The neural network of the worm Caenorhabditis elegans, the power grid of the western United States, and the collaboration graph of film actors are shown to be small-world networks. Models of dynamical systems with small-world coupling display
enhanced signal-propagation speed, computational power, and synchronizability. In particular, infectious diseases spread more easily in small-world networks than in regular lattices.

By making the first progress on the “chromatic number of the plane” problem in over 60 years, an anti-aging pundit has achieved mathematical immortality.

Neuroengineering is faced with unique challenges in repairing or replacing complex neural systems that are composed of many interacting parts. These interactions form intricate patterns over large spatiotemporal scales, and produce emergent behaviors that are difficult to predict from individual elements. Network science provides a particularly appropriate framework in which to study and intervene in such systems, by treating neural elements (cells, volumes) as nodes in a graph and neural interactions (synapses, white matter tracts) as edges in that graph. Here, we review the emerging discipline of network neuroscience, which uses and develops tools from graph theory to better understand and manipulate neural systems, from micro- to macroscales. We present examples of how human brain imaging data is being modeled with network analysis and underscore potential pitfalls. We then highlight current computational and theoretical frontiers, and emphasize their utility in informing diagnosis and monitoring, brain-machine interfaces, and brain stimulation. A flexible and rapidly evolving enterprise, network neuroscience provides a set of powerful approaches and fundamental insights critical to the neuroengineer's toolkit.

17 pages, 6 figures. Manuscript accepted to the journal Annual Review of Biomedical Engineering [1]

References

[1]

D. Bassett S., A. Khambhati N., and S. Grafton T., “Emerging Frontiers of Neuroengineering: A Network Science of Brain Connectivity,” arXiv, 23-Dec-2016. [Online]. Available: https://arxiv.org/abs/1612.08059. [Accessed: 03-Jan-2017]

I ran across a link to this textbook by way of a standing Google alert, and was excited to check it out. I was immediately disappointed to think that I would have to wait another month and change for the physical textbook to be released, but made my pre-order directly. Then with a bit of digging around, I realized that individual chapters are available immediately to quench my thirst until the physical text is printed next month.