David Christian’s “Maps of Time” and “Big History” – a Profound Thesis

Headshot of David Christian
Historian David Christian

David Christian, a trained historian, is one of the leading proponents of the relatively new concept of Big History, which I view as a sea-change in the way humans will begin to view not only the world but our place in it and what we might expect to come in the future.  His work presents a truly monumental and profound thesis and a drastically new framework for where humankind fits into the universe. Of the broad variety of works I’ve read in the past several decades, it is simply one of the most interesting and cohesive theses I’ve come across, and I highly and unreservedly recommend it to everyone I know.  I’d put it on par or above works like Jared Diamond’s Guns, Germs, and Steel and Matt Ridley’s The Rational Optimist among others for its broad impact on how I now view the world. For scientists and researchers it has the potential to be the philosophical equivalent of The Bible and in fact, like many religious texts, it is in effect a modern day “creation myth,” albeit one with a scientific underpinning.

Christian’s work was initially brought to my attention by an article in the Chronicle of Higher Education by Jeffrey R. Young in which he mentioned that Bill Gates was a big fan of Christian’s work and had recommended it himself at a TED conference. (Gates is now also a financial supporter of Christian’s Big History Project.) I myself was aware of the Learning Company’s generally excellent coursework offerings and within a few weeks got an audio copy of the course of forty-eight lectures to listen to on my daily commute.

I’ve now devoured both his rather large text on the subject as well as a lecture series he created for a course on the subject. Below are brief reviews of the two works.The magnum written opus Maps of Time: An Introduction to Big History is an interesting change of reference from a historical perspective combining the disciplines of physics, cosmology, astronomy, geology, chemistry, microbiology, evolutionary theory, archaeology, politics, religion, economics, sociology, and history into one big area of contiguous study based upon much larger timescales than those traditionally taken in the study of historical time periods. Though it takes pieces from many disciplines, it provides for an interesting, fresh, and much needed perspective on who humans are and their place in not only the world, but the entire universe.

By looking at history from a much broader viewpoint (billions of years versus the more common decades or even just a few centuries) one comes away with a drastically different perspective on the universe and life.

Book cover of "The Maps of Time"I’d highly recommend this to any general reader as early as they can find time to read through it, particularly because it provides such an excellent base for a variety of disciplines thereby better framing their future studies. I wish I had been able to read this book in the ninth or tenth grade or certainly at the latest by my freshman year in college – alas the general conception of the topic itself didn’t exist until after I had graduated from university.

Although I have significant backgrounds in most, if not all, of the disciplines which comprise the tapestry of big history, the background included in the book is more than adequate to give the general reader the requisite introductions to these subjects to make big history a coherent subject on its own.

This could be an extremely fundamental and life-changing book for common summer reading programs of incoming college freshman. If I could, I would make it required reading for all students at the high school level. Fortunately Bill Gates and others are helping to fund David Christian’s work to help introduce it more broadly at the high school and other educational levels.

Within David Christian’s opus, there is also a collection of audio lectures produced by The Learning Company as part of their Great Courses series which I listened to as well. The collection of forty-eight lectures is entitled Big History: The Big Bang, Life on Earth, and the Rise of Humanity (Great Courses, Course No. 8050). It provides a much quicker philosophical overview of the subject and doesn’t delve as deeply into the individual disciplines as the text does, but still provides a very cohesive presentation of the overall thesis.  In fact, for me, the introduction to the topic was much better in these audio lectures than it was in the written book. Christian’s lecture style is fantastic and even better than his already excellent writing style.

Because of the scale on which we look at the past, you should not expect to find in it many of the familiar details, names, and personalities that you’ll find in other types of historical teaching and writing. For example, the French Revolution and the Renaissance will barely get a mention. They’ll zoom past in a blur. You’ll barely see them. Instead, what we’re going to see are some less familiar aspects of the past. … We’ll be looking, above all, for the very large patterns, the shape of the past.

David Christian in Maps of Time: An Introduction to Big History

In the audio lectures Christian highlights eight major thresholds which he uses as a framework by which to view the 13.4 billion years of history which the Universe has presently traversed.  Then within those he uses the conceptualization of disparities in power/energy as the major driving forces/factors in history in a unique and enlightening way which provides a wealth of perspective on almost every topic (scientific or historical) one can consider. This allows one to see parallels and connections between seemingly disparate topics like the creations of stars and the first building of cities or how the big bang is similar to the invention of agriculture.

I can easily say that David Christian’s works on big history are some of the most influential works I’ve ever come across – and having experienced them, I can never see our universe in the same naive way again.

For those interested in taking a short and immediate look at Christian’s work, I can recommend his Ted Talk “The History of Our World in 18 Minutes” which only begins to scratch the surface of his much deeper and profound thesis: 

Given how profound the topic of big history is, I’m sure I’ll be writing about and referring to it often. Posts in relation to it can be found here with the tag: “big history“.

Added material below on 21-October-2016

Reading Progress

big-history-reading-progress-chart

Added material below on 23-October-2016

Highlights, Quotes, & Marginalia

Preface to the 2011 Edition
In Big History and the Future of Humanity, Fred Spier has built on an earlier work of his and on the work of Eric Chaisson to produce what is currently by far the most sophisticated attempt to construct a thematic scaffolding for big history. He carefully links the idea of increasing complexity with the associated themes of energy flows and the idea of goldilocks conditions—the notion that complexity can increase only under very special conditions and within quite exacting “boundary conditions.” Here are broad theoretical ideas that can help give greater depth and coherence to the story told within big history.
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big history promises to open up exciting new research agendas (including the meaning of complexity and energy flows, and the role of information across many disciplines),
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Introduction: A Modern Creation Myth?
sociologist Émile Durkheim referred to as “anomie”: the sense of not fitting in,
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Russian matryoshka doll
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Accounts of the past that focus primarily on the divisions between nations, religions, and cultures are beginning to look parochial and anachronistic—even dangerous.
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capacious
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Chaisson, Eric J. Cosmic Evolution: The Rise of Complexity in Nature. Cambridge, Mass.: Harvard University Press, 2001.
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Margulis, Lynn, and Dorion Sagan. Microcosmos: Four Billion Years of Microbial Evolution. London: Allen and Unwin, 1987.
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Maynard Smith, John, and Eörs Szathmáry. The Origins of Life: From the Birth of Life to the Origins of
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Spier, Fred. The Structure of Big History: From the Big Bang until Today. Amsterdam: Amsterdam University Press, 1996.
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Part I: The Inanimate Universe
Rig-Veda
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This is very much how modern nuclear physics views the idea of a vacuum: it is empty but can nevertheless have shape and structure, and (as has been proved in experiments with particle accelerators) “things” and “energies” can pop out of the emptiness.
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Popol Vuh, or “Council Book,” a sixteenth-century Mayan manuscript,
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Dr. Lightfoot from Cambridge “proved” that God had created humans at exactly 9:00 AM on 23 October 4004 BCE.13
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The particles that did find a partner were transformed into pure energy,
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Perhaps this is where dark matter and energy are hiding?
As an anonymous wit is supposed to have put it: “Hydrogen is a light, odorless gas which, given enough time, changes into people.”25
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The idea that form and matter are different expressions of the same underlying essence was proposed by the Italian Giordano Bruno as early as 1584, in a book called Concerning the Cause, Principle, and One.
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Eric Chaisson’s Cosmic Evolution (2001) is an attempt to think through the meaning of order and entropy at many different scales, from stars to microbes,
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The second law of thermodynamics ensures that all complex entities will eventually die; but the simpler the structure, the better its survival chances, which is why stars live so much longer than humans
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Even in the densest part of the galaxy, the disk, regions of empty space normally contain only about one atom in each cubic centimeter. But in the earth’s atmosphere, there may be 25 billion billion molecules in the same space.15 And pouring though this matter is the energy emitted every second by the Sun. In other words, human history has taken place in a pocket of the universe that is dense in matter and packed with energy. It is the extraordinary richness and complexity of this environment that made life possible.
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A Danish scientist, Nicholas Steno, first argued that fossils were the remains of organisms that had once lived on earth.
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Charles Lyell first stated clearly what came to be known as the principle of uniformitarianism.
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As the English philosopher Francis Bacon pointed out in 1620, it was easy to see from these maps that the continents looked like pieces of a jigsaw puzzle. This similarity was most striking when the west coast of Africa was matched up with the east coast of South America.
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The idea that the continents really had drifted apart was given a thorough scientific basis in a book called The Origin of Continents and Oceans, written in 1915 by a German geographer, Alfred Wegener.
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Gondwana sequence
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uppermost layer of the earth (the lithosphere) consists of a number of rigid plates, like a cracked eggshell. There are eight large plates and seven smaller ones, as well as smaller slivers of material.
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asthenosphere
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Pangaea
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Panthalass
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Laurasia
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Gondwanaland
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Rodinia
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Part II: Life On Earth
“The unfolding of events in the life cycle of an organism exhibits an admirable regularity and orderliness, unrivalled by anything we meet with in inanimate matter.”
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In Schrödinger’s famous phrase, each living organism seems to have an astonishing capacity for “continually sucking orderliness from its environment.”
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Unlike stars or crystals, which are general, all-purpose antientropy machines, …
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Think of homoestasis vs longevity
Darwin rarely used the term evolution, perhaps because it seems to imply some sort of mystical force that drives biological change in particular directions and thus would contradict his own view of biological change as a more open-ended process.
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Herbert Spencer, who did the most to popularize the term,
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carunculated
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Erasmus Darwin, suggested that species evolved so as to adapt better to their environments.
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In a book first published in 1809, the French naturalist Jean-Baptiste Lamarck suggested a possible mechanism. Perhaps minor changes acquired during a creature’s lifetime could somehow be passed on to its descendants.
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Time we spend in the gym does not guarantee that our children will be fit.
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Though epigenitics may be at work; see the studies of weight of self vs peers from c. 2010
Evolution works in fits and starts, according to the modern theory of “punctuated evolution,’ which was proposed by Niles Eldridge and Stephen Jay Gould in 1972.
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1920s by Alexander Oparin and J. B. S. Haldane, uses the basic ideas of evolutionary theory to explain not just the evolution of life on earth but also its initial appearance.
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But precisely how chemical evolution generated the first living organisms remains unclear. To understand these difficulties, we must break the problem into several levels. First, we need to explain how the basic raw materials of life were created: the chemical level. Second, we need to explain how these simple organic materials were assembled into more complex structures. Finally, we need to explain the origins of the precise mechanisms of reproduction encoded in the DNA that is present in all living organisms today. At present, we have reasonably good answers to the first question; we have plausible answers to the second question; and we are still puzzled by the third question.
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Harold Urey and his graduate student, Stanley Miller.
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Fred Hoyle and Chandra Wickramasinghe have argued that Earth was seeded with life from outside. This theory is known as Panspermia.
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A. G. Cairns-Smith has suggested that in shallow water, tiny crystals of clay may have provided a template for the formation of more complex molecules.
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Humans do not have the 60,000 to 80,000 genes we once believed were necessary to construct us but half that number, about 30,000. Roundworms have two-thirds as many genes as us (ca. 19,000), and fruit flies just under half (ca. 13,000); even Escherichia coli, a bacterium that inhabits our gut, may have as many as 4,000 genes. So, though constructing large organisms is tougher than constructing small organisms, the difference is not as great as we once imagined.
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It would seem that we’re not really becoming that more complex from a relative perspective here. What is the next major jump on the hockey stick?
As Margulis and Sagan put it: “For the macrocosmic size, energy, and complex bodies we enjoy, we trade genetic flexibility.”
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The first extensive fossil evidence of multicellular organisms dates from the Ediacaran era, ca. 590 million years ago. But the fossil record of multicellular organisms really becomes abundant during the Cambrian era, from ca. 570 million years ago.
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In the middle of the nineteenth century, the German biologist Ernst Haeckel suggested that all single-celled organisms be classified within a separate kingdom of Protista. Then, in the 1930s, biologists realized that there was a fundamental difference between cells with nuclei and those without. As a result, they began to divide all organisms into two distinct kingdoms, the Prokaryota (organisms whose cells had no nuclei) and the Eukaroyta (organisms whose cells had nuclei). In some systems, the Eukaryota also include all multicellular organisms. In the second half of the twentieth century, powerful arguments emerged for the creation of separate kingdoms for fungi and for viruses (which are so simplified that they cannot even reproduce without hijacking the metabolic systems of other organisms). In the 1990s, Carl Woese proposed a new large classification to distinguish between the archaea and other forms of bacteria. Like all prokaryotes, archaea do not have nuclei; but unlike other prokaryotes they take in energy neither from sunlight nor from oxygen but from other chemicals.
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Chixculub
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John Maynard Smith and Eörs Szathmáry’s The Origins of Life (1999) is a history of life on Earth, constructed around the central idea of the evolution of complexity.
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Part III: Early Human History: Many Worlds
Net primary productivity (NPP) is that portion of energy from sunlight that enters the food chain through photosynthesis and is turned into plant material.
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This means that the impact of human history will be visible on scales of at least a billion years.
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new ways of extracting resources from their environments.
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We have seen that the emergence of new forms of complexity always involves the creation of large structures within which previously independent entities are locked into new forms of interdependence and new rules of cooperation.7 Following this hint, we should expect to find that the transition to human history is primarily marked not by a change in the nature of humans as individuals but rather by a change in the way individuals relate to each other.
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learning collectively
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In an article first published in 1967, two biochemists working in the United States, Vincent Sarich and Alan Wilson, argued that much genetic change is subject to similar rules.
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neoteny
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“Millennium Man”
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another possible candidate for the oldest hominine, Ardipithecus ramidus kadabba,
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gracile
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It is possible that tool use evolved through a process known as Baldwinian adaptation (named after the nineteenth-century American psychologist who first described it systematically). This is a form of evolutionary change that appears to combine Darwinian and cultural elements, because behavioral changes lead to changes in an animal’s lifeways, thereby creating new selective pressures that lead, over time, to genetic changes.
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the so-called Levallois or Mousterian tools.
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neoteny
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Roger Lewin’s Human Evolution (4th ed., 1999)
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Steven Mithen has proposed that a number of once discrete brain modules, some of which may have been present in the earliest hominines, merged quite suddenly—perhaps within the last hundred thousand years—in a sort of linguistic “big bang.”
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The Symbolic Species, Terrence Deacon
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Two factors stand out: the volume and variety of the information being pooled, and the efficiency and speed with which information is shared.
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In a deliberately provocative essay published in 1972, the anthropologist Marshall Sahlins describes the world of the Stone Age as “the original affluent society.”
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In his simple but influential model of social structures, Eric Wolf has suggested that “kin-ordered” societies constitute a major type of human community, one that survives in many different forms even in the modern world.26
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Australian archaeologist Rhys Jones referred to such techniques as “fire stick farming.”39 Fire stick “farmers” deliberately set fire to bushland in regular cycles. In part, their aim was to prevent buildups of combustible material that could lead to hotter and more dangerous fires. But by clearing away underbrush, fire stick farming also encouraged the growth of new plants that, in turn, attracted browsers that could be hunted. Recent research suggests that such techniques may have been used as early as 45,000 years ago.40
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Part IV: The Holocene: Few Worlds
All of recorded human history has taken place within the Holocene interglacial.
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allopatric
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loess
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The Trap of Sedentism
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In fact, most of human history (chronologically speaking) has taken place in communities quite innocent of state power. Even in the villages of the early agrarian era, for most people, most of the time, the important relationships were personal, local, and fairly egalitarian. Most households were self-sufficient, and people dealt with each other as people rather than as the representatives of institutions.
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But exploitation, like symbiosis, is never simple or unambiguous. Like predation in the nonhuman world, it can take more or less brutal forms. Lynn Margulis and Dorion Sagan observe, “In the long run, the most vicious predators, like the most dread disease-causing microbes, bring about their own ruin by killing their victims. Restrained predation—the attack that doesn’t quite kill or does kill only slowly—is a recurring theme in evolution.”
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irrigation could raise agricultural productivity decisively, which is why irrigation has been one of the most revolutionary of all technological innovations.
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But population growth itself counts as a form of intensification, for in the era before fossil fuels, the energy resources available to human societies came mostly from human or animal muscle power.
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Inequality is what all top-down theories of state formation predict.
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as the sociologist Émile Durkheim first suggested, our thinking about the way the universe works often mirrors the way our own societies work.
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But most were used as sources of stored energy for their owners: where human labor power was as important a source of energy as oil is today, controlling energy meant controlling people. To make slaves more amenable to control, they were often separated at birth from their families. And, like domestic animals, many were deliberately kept in a state of infantile dependence that inflicted a sort of psychic amputation on them—they remained like children, and their helplessness made them easier to control. Both animal and human slaves could be controlled best if kept economically and psychically dependent on their owners.
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druzhiny
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Outside the cities, they usually had little authority over the more localized forms of violence used to collect taxes, prosecute offenders or deal with banditry, or right local injustices. These powers were exercised by local elites or kinship groups. For most individuals, the righting of wrongs remained the duty of the household or kin group, which might seek the support of local patrons or officials.
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Sounds like modern day Muslim middle eastern practice now…
Wolf calls “tributes.” This is justification for regarding societies with states as an entirely new type of social structure. Wolf treats the emergence of what he calls “tribute-taking” societies as a major transformation in the lifeways and the organization of human societies.
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They include the emergence of dense populations, which generated a complex division of labor that posed new organizational problems, led to increased need for conflict resolution and to more frequent warfare, and encouraged the building of large monumental buildings as well as the creation of some form of writing.
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The demographic dynamism introduced into human history by agriculture ensured that sooner or later, humans, like termites, would face the novel challenge of living in dense communities of their own species. For all the local differences, the solutions humans found in different parts of the world turned out to be remarkably similar to each other—and also strikingly similar to those found by termites and other social insects.
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Marvin Harris’s classic essay, “The Origin of Pristine States” (1978).
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we can think of four main types of societies in this era: three—foragers, independent farmers, and pastoralists—lack states; one—agrarian civilizations—has states.
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World historians have become increasingly sensitive to the importance of large systems of interaction, and have often analyzed them using the notion of world-systems. Immanuel Wallerstein, the originator of such theories, argued that particularly in the modern era, it was necessary to analyze not just particular nations or civilizations, but rather the larger networks of power and commerce in which they were entangled, because these networks explained features that could not be explained solely from the internal history of particular regions. Wallerstein called these networks “world-systems,” even though they did not literally embrace the entire world, on the grounds that in many regards they functioned as separate worlds.
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Centers of gravity gave structure and shape to large networks of exchange, while hub regions were more lightweight and were more easily transformed by the exchanges that swept through them. So it was often in hub regions that significant innovations first became important because here was where they could have the greatest impact, while the mass and momentum of centers of gravity ensured that those regions normally changed more slowly.
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During the reign of Sargon of Akkad (who ruled from ca. 2350 BCE for ca. 50 years), we have the first evidence for a new stage in state formation: the appearance of a state controlling several different city-states and their hinterlands.14
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chinampa
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Rein Taagepera has tried to measure the areas ruled by “imperial systems” of Afro-Eurasia at different dates.
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three other factors shaped the pace and nature of innovation in this period: population growth, the expanding activity of states, and increasing commercialization and urbanization.
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Scale as a Source of Innovation
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“the respiration of a social structure.”
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One reason for their immense influence was the overwhelming importance of the agrarian sector. Where most forms of production relied on organic materials and energy sources, agricultural output set limits to the production not just of foodstuffs but also of clothing, housing, energy, productive implements, and even parchment and paper.33 Because agriculture was the main motor of economic growth in the agrarian era, rates of innovation in agriculture dominated medium-term economic, political, and even cultural cycles.
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States as Sources of Accumulation
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The most stable states and the wisest rulers protected the productive base of their societies by taxing lightly, maintaining basic infrastructure, upholding law and order, and encouraging growth in rural populations and agricultural output.
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Thus, an eleventh-century CE Muslim prince from Tabaristan wrote in a book for his son, “Make it your constant endeavor to improve cultivation and to govern well; for understand this truth: the kingdom can be held by the army, and the army by gold; and gold is acquired through agricultural development and agricultural development through justice and equity. Therefore be just and equitable.”50
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Powerful states spent freely on large prestige projects, including cities such as the Achaemenid capital, Persepolis. Such projects were designed to overawe subjects and rivals, but they also provided employment and attracted merchants and artisans.
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In Muscovite history, the reign of Ivan the Terrible offers a horrifying example of the dangers of excessive predation.
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First, elites in tribute-taking societies had to be specialists in coercion and management rather than in production.
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Stable and long-lived polities such as that of China thrived in part because they were rich enough and durable enough to maintain predictable and relatively light levels of taxation, which gave peasants a greater stake in productivity-raising innovations.57
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as Joel Mokyr has argued, technological innovation is unlikely to happen quickly where those who work lack wealth, education, and prestige, and those who are wealthy, educated, and have prestige know nothing about productive work.
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Exchange, Commerce, and Urbanization
Highlight (yellow) – 10. Long Trends in the Era of Agrarian “Civilizations” > Location 7165
Thus urbanization itself dampened population growth, and it did so most decisively when cities grew fastest.
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Though tributary states normally tolerated and sometimes encouraged commerce, their predatory methods and willingness to resort to force were ever-present threats to the freedoms needed for trade to flourish. There was therefore a fundamental long-term conflict between the methods of tribute takers and those of merchants; and as long as tributary elites dominated political systems, this conflict limited the productivity-raising potential of commercial activity.
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Part V: The Modern Era: One World
Scythians north of the Black Sea more than 2,000 years ago:
Highlight (yellow) – 11. Approaching Modernity > Location 7432
But though they are on the whole less violent, personal relations in modern urban communities also lack the intimacy and continuity of those in most traditional societies. Increasingly, they are casual, anonymous, and fleeting. These changes may help explain the loss of a clear sense of values and meaning in modern lives, a subtle and disorienting alteration in the quality of modern life that the French sociologist Émile Durkheim referred to in the late nineteenth century as “anomie.”
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Interesting in light of Civility for P.M. Forni.
The German sociologist Norbert Elias has argued that these changes have reached deep within our psyches, as modern forms of work and time discipline, enforced through the market, have shaped behavior in interpersonal relations, table manners, and attitudes toward sexuality. He has shown how the “emotional economy” typical in the modern world arises out of a relaxation of external restraints combined with an intensification of internal restraints: “The compulsions arising directly from the threat of weapons and physical force gradually diminish, and . . . those forms of dependency which lead to the regulation of the affects [feelings or emotions] in the form of self-control, gradually increase.”
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A system of knowledge that is good at manipulating the material world is exactly what we need. Without such knowledge, we could not possibly support a human population of 6 billion.
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As Daniel Headrick writes: “Knowledge is both cause and effect of economic growth, and the information industry has been the primary cause of the acceleration of technological change in the past 200 years.”
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Necessity is not always the mother of invention.
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in Britain iron makers had tried to use coal for almost two centuries before Abraham Darby showed them how to use coke in the early eighteenth century.
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expanding networks of exchange encouraged specialization, which stimulated innovation in productive techniques—a type of growth we can refer to as Smithian.42
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From Joel Mokyr, The Lever of Riches: Technological Creativity and Economic Progress (Oxford: Oxford University Press, 1992),
Highlight (green) – 11. Approaching Modernity > Location 7772
the very nature of most premodern states suggests that as a general rule, in agrarian civilizations tribute-taking generated more wealth and certainly more power than commercial exchanges. This differential helps us understand what might at first appear puzzling: though commercial networks are as old as agrarian civilization, their impact on rates of innovation has been limited until the past two or three centuries. Why, then, did commercial exchanges suddenly become so much more significant in the modern era? Did they reach some critical threshold?
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And what then is the next threshold? For think of what the Internet is doing to the entertainment industry and their reticence to go along with it.
Speaking generally, it is the steepness of this gradient of wealth that accounts for capitalism’s remarkable dynamism, just as the large temperature gradient between the Sun and the space surrounding it drives complex processes on Earth.
Highlight (yellow) – 11. Approaching Modernity > Location 7819
is the steepness of the gradient that drives wealth so efficiently through capitalist societies and that helps explain why, paradoxically, modern states have to be so much larger and more complex than the states of the tributary world.
Highlight (yellow) – 11. Approaching Modernity > Location 7823
So the onus is on the workers to ensure that their labor is productive enough to find a buyer. In this way, the economic lash can stimulate genuine, even creative, self-discipline, whereas the overseer’s whip can generate no more than grudging conformity.
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J. L. Anderson’s Explaining Long-Term Economic Change (1991) is a useful introduction to the theoretical literature.
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Robert Lopez, has called the “commercial revolution of the Middle Ages” a fundamental turning point in modern world history.
Highlight (yellow) – 12. Globalization, Commercialization, and Innovation > Location 8067
Well-to-do merchants accumulate goods and redouble their profits, while the less well-to-do sit in their shops and sell. They control the markets and daily enjoy their ease in the cities. They take advantage of the pressing needs of the government to sell at twice the normal price. Their sons do not plough or hoe. Their daughters do not raise silkworms or weave. They have fancy clothing and stuff themselves on millet and meat. They earn fortunes while suffering none of the hardships which the farmers suffer. Their wealth enables them to hobnob with princes and marquises, and to dispose of greater power than the officials.29
Highlight (yellow) – 12. Globalization, Commercialization, and Innovation > Location 8185
This quote about 2nd century BCE China sounds a lot like modern day China.
this process was completed by 1279 after the conquest of South China by the Mongols under Kublai Khan. After reunification, two of the three conditions encouraging states to support commercialization (small size and intense rivalries) vanished, and the third (easy access to rich trading systems) lasted only slightly longer.
Highlight (yellow) – 12. Globalization, Commercialization, and Innovation > Location 8270
Charles Tilly’s Coercion, Capital, and European States, AD 990–1992 (rev. ed., 1992).
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Indeed, Spain depended so heavily on American silver that when the supply ran out in the seventeenth century, its commercial and political influence declined.
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piratical
Highlight (orange) – 12. Globalization, Commercialization, and Innovation > Location 8631
wealth. The mercantilist policies of European states in the seventeenth century—such as the Navigation Acts of the English commonwealth, which protected British commerce within British colonies—are good examples of new government attitudes toward commerce and the actions that these changes encouraged. Also illustrating this trend is the proliferation throughout Europe of patent laws, which were pioneered in Venice in the fifteenth century. Governments also began to promote innovation through the founding of scientific societies or the offering of prizes.
Highlight (yellow) – 12. Globalization, Commercialization, and Innovation > Location 8641
Over time, commercialization transformed traditional tributary elites. Such transformation was most likely to occur when demands on elite incomes rose sharply in environments where commercial revenues were available for the taking. The English wool trade offers a classic example, for it tempted landowners to clear the land of tenants and replace them with sheep, particularly in the sixteenth century, when new land became available as a result of the dissolution of the monasteries.
Highlight (yellow) – 12. Globalization, Commercialization, and Innovation > Location 8648
“it is gain, whether vile or sordid, that derogates from nobility, whose proper role is to live off rents.”
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the invention in France of the Jacquard loom, which pioneered the use of digital coding as a form of mechanical control (1801);
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As early as 1837, the French revolutionary Blanqui used the term industrial revolution
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For most rural dwellers, these changes were catastrophic.
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This is now what is happening in most of the rest of the world now.
The appearance of societies in which most people depended entirely on markets for their subsistence was a new phenomenon, and it gave a tremendous stimulus to commercial production of goods of mass consumption.
Highlight (yellow) – 13. Birth of the Modern World > Location 9097
The idea that atmospheric pressure was a potential source of mechanical power had a history going back at least to the sixteenth century, and it may have been familiar in China as well as in Europe.23
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In 1718, a new owner, Thomas Lombe, in an early example of planned industrial espionage, stole techniques already in use in Italy to set up an improved factory.
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Richard Arkwright’s water frame, James Hargreaves’s spinning jenny, and Samuel Crompton’s spinning mule, a modification of the jenny.24
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Karl Polanyi argues in a classic study of modernity,
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Where literacy spread, knowledge became more abstract and less personal, and abstract knowledge began to acquire an authority quite independent from the prestige of particular teachers.
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In the nineteenth century, beginning in Germany, science itself began to be incorporated into entrepreneurial activity as companies set up laboratories specifically to raise productivity and profits. By the late nineteenth century, scientific research was taking a leading role in processes of innovation that might have simply petered out if they had continued to rely on the technical and practical skills of individual entrepreneurs and artisans.
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Think about how this is done now and how much of it is done by universities instead of by industry. Where is his innovation happening in the future?
The modern world is ruled by larger and more impersonal forces, from faceless bureaucracies to abstractions such as “inflation,” or “the rule of law.” Where abstract forces take over the work of coercion from the landlord, the executioner, and the overseer, it is not surprising that there should emerge cosmologies ruled by equally abstract forces.
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Joel Mokyr, The Lever of Riches (1990),
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Charles Tilly, Coercion, Capital, and European States, AD 990–1992 (rev. ed., 1992), is good on some of the political changes associated with the Industrial Revolution.
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During the “great depression” of the 1870s, it became apparent for the first time that economic growth could falter because of overproduction as well as underproduction.
Highlight (yellow) – 14. The Great Acceleration of the Twentieth Century > Location 9700
Over the following decades, it became clear that in a world of steadily increasing productivity, the problem of finding (or creating) markets would shape the rhythms of economic activity much as the problem of insufficient productivity had done in the agrarian era. As a result, the modern era is dominated by cycles of activity with a different (normally a shorter) periodicity, which we know as business cycles.
Highlight (yellow) – 14. The Great Acceleration of the Twentieth Century > Location 9702
Indeed, lifestyles have changed so greatly that they may be exerting a significant evolutionary impact on human bodies.
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The tensions and dislocations of the hurricane of change affecting the entire globe will ensure that conflict remains endemic, and modern weaponry will ensure that local conflicts continue to cause great suffering.
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Lester Brown argues that “while the Agricultural Revolution transformed the earth’s surface, the Industrial Revolution is transforming the earth’s atmosphere.”
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Part VI: Perspectives On The Future
“With chaos, it is sensitivity to initial conditions that makes the dynamics unpredictable. With emergent properties, it is the general inability of observers to predict the behavior of nonlinear systems from an understanding of their parts and interactions.”
Highlight (yellow) – 15. Futures > Location 10163
it is better than doing nothing at all, just as studying the form at a racetrack is better than tossing a coin. In the long run, you will end up with more money if you study the form.
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the space technologies envisioned by the Russian schoolteacher Konstantin Tsiolkovsky, which enabled the first human to leave Earth on 12 April 1961 and the first human to land on another heavenly body on 21 July 1969,
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Appendix 2: Chaos and Order
But the patterns we detect are really there, and their existence is one of the great puzzles of the universe. Why is there order of any kind? And what rules allow the creation and evolution of ordered structures?
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On Earth, the temperature differential between our sun and surrounding space provides the free energy needed to create most forms of complexity, including ourselves; energies created early in the history of our solar system drive the internal heat battery of Earth, which drives plate tectonics. These differentials enable energy to flow, and energy flows make patterns possible. And given enough time, the mere possibility of pattern makes it likely that patterns of many different kinds will eventually appear.
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After the first problem—explaining how order of any kind is possible—is addressed, the second problem remains. How did complex entities emerge, and, once they had emerged, how did they sustain themselves long enough to be noticed by us (or to be us)?
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Paradoxically, the tendency toward increasing entropy—the drive toward disorder—may itself be the engine that creates order.
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The drive toward disorder seems to create new forms of order, just as the energy of falling water can cause droplets of water to splash upward, or a river’s current can create eddies in which small amounts of water flow against the main current.
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Roughly speaking, the more complex a phenomenon is, the denser the energy flows it must juggle and the more likely it is to break down. So we should expect that as entities become more complex, they become less stable, shorter-lived, and rarer. Perhaps even a slight increase in complexity can sharply increase their fragility and, therefore, their scarcity.
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What we can do is to describe some of the ways in which complex structures emerge. The fundamental rule seems to be that complexity normally emerges step by step, linking already existing patterns into larger and more complex patterns at different scales.
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new rules of construction and change seem to come into play. These are known as emergent properties,
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Notes
“Leibig’s Law of the Minimum . . . states that populations will be limited by critical resources (e.g., water) that are in shortest supply” (Allen W. Johnson and Timothy Earle, The Evolution of Human Societies, 2nd ed. [Stanford: Stanford University Press, 2000], pp. 14–15).
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articles, “Immunological Time Scale for Hominid Evolution”; it was published in Science, 1 December 1967, pp. 1200–1203.
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There is a good short survey of theories of growth in J. L. Anderson, Explaining Long-Term Economic Change (Basingstoke: Macmillan, 1991); and see the survey in Mokyr, The Lever of Riches, chap. 7 (“Understanding Technological Progress”).
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Guide to highlight colors

Yellow–general highlights and highlights which don’t fit under another category below
Orange–Vocabulary word; interesting and/or rare word
Green–Reference to read
Blue–Interesting Quote
Gray–Typography Problem
Red–Example to work through

Editor’s Note: Data relating to reading progress was added to this post on 10/21/16. Data relating to highlights, quotes, and marginalia added on 10/23/16.

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Christoph Adami: Finding Life We Can’t Imagine | TEDx


–via Ted.com
 
Adami’s work is along similar lines to some of my own research. This short video gives an intriguing look into some of the basics of how to define life so that one can recognize it when one sees it.

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The Central Dogma of Molecular Biology

Francis Crick, OM, FRS (1916 – 2004), a British molecular biologist, biophysicist, and neuroscientist
first articulated in 1958 and restated in August 1970
“Central dogma of molecular biology.” Nature 227 (5258): 561-3.
Bibcode 1970Natur.227..561C doi:10.1038/227561a0 PMID 4913914

 

Central Dogma of Molecular Biology
Central Dogma of Molecular Biology

 

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Book Review: John Avery’s “Information Theory and Evolution”

Information Theory and Evolution Book Cover Information Theory and Evolution
John Avery
Non-fiction, Popular Science
World Scientific
January 1, 2003
paperback
217

This highly interdisciplinary book discusses the phenomenon of life, including its origin and evolution (and also human cultural evolution), against the background of thermodynamics, statistical mechanics, and information theory. Among the central themes is the seeming contradiction between the second law of thermodynamics and the high degree of order and complexity produced by living systems. This paradox has its resolution in the information content of the Gibbs free energy that enters the biosphere from outside sources, as the author shows. The role of information in human cultural evolution is another focus of the book. One of the final chapters discusses the merging of information technology and biotechnology into a new discipline — bio-information technology.

Information Theory and EvolutionInformation Theory and Evolution by John Avery
My rating: 3 of 5 stars

This is a fantastic book which, for the majority of people, I’d give a five star review. For my own purposes, however, I was expecting far more on the theoretical side of information theory and statistical mechanics as applied to microbiology that it didn’t live up to, so I’m giving it three stars from a purely personal perspective.

I do wish that someone had placed it in my hands and forced me to read it when I was a freshman in college entering the study of biomedical and electrical engineering. It is far more an impressive book at this level and for those in the general public who are interested in the general history of science and philosophy of the topics. The general reader may be somewhat scared by a small amount of mathematics in chapter 4, but there is really no loss of continuity by skimming through most of it. For those looking for a bit more rigor, Avery provides some additional details in appendix A, but for the specialist, the presentation is heavily lacking.

The book opens with a facile but acceptable overview of the history of the development for the theory of evolution whereas most other texts would simply begin with Darwin’s work and completely skip the important philosophical and scientific contributions of Aristotle, Averroes, Condorcet, Linnaeus, Erasmus Darwin, Lamarck, or the debates between Cuvier and St. Hilaire.

For me, the meat of the book was chapters 3-5 and appendix A which collectively covered molecular biology, evolution, statistical mechanics, and a bit of information theory, albeit from a very big picture point of view. Unfortunately the rigor of the presentation and the underlying mathematics were skimmed over all too quickly to accomplish what I had hoped to gain from the text. On the other hand, the individual sections of “suggestions for further reading” throughout the book seem well researched and offer an acceptable launching pad for delving into topics in places where they may be covered more thoroughly.

The final several chapters become a bit more of an overview of philosophy surrounding cultural evolution and information technology which are much better covered and discussed in James Gleick’s recent book The Information.

Overall, Avery has a well laid out outline of the broad array of subjects and covers it all fairly well in an easy to read and engaging style.

View all my reviews

Reading Progress
  • Started book on 07/11/11
  • Finished book on 08/14//11
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📅 18th International C. elegans Meeting, 22nd-26th June 2011

Attending 18th International C. elegans Meeting
The Organizing Committee invites you to attend the 18th International C. elegans Meeting, sponsored by the Genetics Society of America. The meeting will be held June 22 – 26, 2011 at the University of California, Los Angeles campus. The meeting will begin on Wednesday evening, June 22 at 7:00 pm and will end on Sunday, June 26 at 12:00 noon. On Friday, June 24 at 5:00 pm there will be a Keynote Address by Joseph Culotti, Samuel Lunenfeld Research Institute, Toronto, Canada
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Synthetic Biology’s Hunt for the Genetic Transistor | IEEE Spectrum

Synthetic Biology's Hunt for the Genetic Transistor (spectrum.ieee.org)
How genetic circuits will unlock the true potential of bioengineering

This is a great short article on bioengineering and synthetic biology written for the layperson. It’s also one of the best crash courses I’ve read on genetics in a while.

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Bill Davenhall at TEDMED 2009 on Geomedicine: How Your Environment May Affect Your Health

TEDMED 2009 on Geomedicine: How Your Environment May Affect Your Health from TEDMED
Does where you live have an impact on your overhall health? Bill Davenhall believes that the location of our homes is critical to our medical history.

 

This is a great thing to think about the next time your doctor asks for your medical history. Perhaps with more data and a better visualization of it, it may bring home the messages of pollution and global warming.

Stem cell treatment goes from lab to operating room | CNN.com

Stem cell treatment goes from lab to operating room (cnn.com)
Imagine having your back cut open, part of your spine removed, a stabilizing device that resembles a mini oil rig mounted on your back, the outer membrane of your spinal cord sliced open and experimental stem cells injected into it -- all for the advancement of science because it's not expected to benefit you.

Another article announcing the first stem cells being transplanted into a human patient in the United States. I worked with the researchers and surgeon in this experiment and built the microinjectors that were used in the lead up experiments as well as for this first patient.

Atlanta, Georgia — Imagine having your back cut open, part of your spine removed, a stabilizing device that resembles a mini oil rig mounted on your back, the outer membrane of your spinal cord sliced open and experimental stem cells injected into it — all for the advancement of science because it’s not expected to benefit you.

John Cornick, 51, did just that earlier this month as part of a groundbreaking clinical trial.

Almost a year ago, Cornick was told he had ALS — better known as Lou Gehrig’s disease. The diagnosis left him “fairly devastated,” he says.

He knew the prospects were grim because there is no cure.

But John wasn’t giving up so quickly, nor was his wife, Gina.

“I knew he was a fighter from the beginning and he really wanted to do something,” Gina Cornick says. She found information about a clinical trial on online and immediately signed him up, even though she had no idea where it was being held.

ALS destroys the nerve cells in the brain and spine which control muscle movement. When the brain can no longer tell muscles to move, they eventually die, depriving the patient of the ability to move arms and legs and eventually breathe.

The goal of this phase 1 trial is to determine whether fetal stem cells can safely be injected into the spinal cord. Ultimately, researchers hope to show that these cells may slow or halt the progression of the fatal disease.

But for now, the only goal is establishing safety.

Clinical trial

The Cornicks live in North Carolina, just a few hours from Atlanta, Georgia’s Emory University, the site of the trial. It is the first FDA-approved clinical trial to inject fetal stem cells directly into the spinal cord of an adult.

Dr. Jonathan Glass, director of Emory’s ALS center, is overseeing the trial. Cornick and two previous patients in the trial are heroes, says Glass, because at this point, the trial will likely produce only information, not results.

“In reality what do these patients have? Time, families and their life and we’re putting all of these at risk,” says Glass.

Dr. Lucie Bruijn, science director of the ALS Association, says the progress being made in this clinical trial is exciting. “We’ve been able to move it forward … from animal testing now into actual patients.” The treatment had not been tried in humans before.

Glass hopes this trial will lead to a new form of treatment for people with ALS. “We’re testing multiple things: We’re testing the safety of the surgery; we’re testing the cells; we’re testing immunosuppressants[because scientists do not know whether the body will reject the cells].” They are also testing how well Cornick handles this major surgical procedure, says Glass.

“After we’re finished with the first 12 or 18 patients we will know whether this is surgery that patients can tolerate.”

As he was prepped for surgery, Cornick was hopeful but realistic. “Well, of course you’d like to get up and walk … but I know that’s not going to happen.”

Stem cells

The stem cells used in the surgery are shipped overnight from Maryland, where Neuralstem, the company funding the trial, is based. The stem cells’ source is donated tissue from the spinal cord of an 8-week old aborted fetus, which was donated to the company. The company has developed a method that enables growth of millions of stem cells from this single source of human nerve stem cells.

Before the surgery can begin, a technician at Emory has to verify that a majority of stem cells made it to Atlanta alive. At least 70 percent have to be viable. In this case three samples under the microscope showed 85 percent of the cells arrived alive.

Lead researcher Dr. Eva Feldman, a neurologist at the University of Michigan, designed the trial just four years ago. After a lot of animal testing, her team determined that using fetal nerve stems rather than human embryonic or adult stem cells (such as bone marrow stem cells) was most effective, she says.

Stem cells have the ability to turn into different cells in the body. However, human embryonic stem cells, which come from 4- or 5-day-old embryos, also been found to sometimes turn into cancer cells. Fetal stem cells, such as those used in this trial, are a few weeks older and have already taken on a specific identity — in this case nerve cells.

Feldman says the fetal stem cells used in this trial did not become any of the unwanted cell types. “That’s very, very important,” she says.

Surgery

Animal testing also proved very useful when it came to figuring out how to actually inject the stem cells. Emory University’s neurosurgeon Dr. Nicholas Boulis invented the device that holds the needle that injects the stem cells. The goal is to inject the cells without injuring the spine and causing even more paralysis. He practiced on 100 pigs before attempting the procedure on a human.

Boulis says it’s critical that the injection be done in a very slow and controlled way.

“If you inject quickly, you’re going to create pressure at the head of the needle and that can cause damage,” Boulis says. That pressure can also inflate an area in the spinal cord which could cause the stem cells to seep back out of the cord when the needle is pulled out, he says. “So by pumping [cells] in slowly you have more security that you are not going to have reflux and you’re not going to have damage.”

Dr. Jeffrey Rothstein, who heads the ALS research center at Johns Hopkins University and is not connected to this trial, said work on this method is a big achievement. “This is purely about how to surgically deliver cellular therapy to spinal cord,” he says. “It’s never been done before.”

After the spinal cord was exposed, the injections began. Cornick got five — each one contains about 100,000 stem cells.

The four-and-a-half hour surgery went smoothly, Boulis, says. “There were no surprises.”

Post-surgery

A day after surgery, Cornick was lying flat in a hospital bed, chatting and laughing with some friends from North Carolina.

One week after surgery, he says he felt amazingly well and was still hopeful the cells would do some good for him.

Two weeks later Cornick’s stitches were removed and he was able to drive home. But he will be making frequent visits back to Atlanta as Glass and his team continue to monitor him.

Neuralstem’s Chief Scientific Officer Karl Johe says after the trial’s safety board reviews all existing data, including Cornick’s results, a fourth patient can be treated with the stem cells.

“Patients Four, Five and Six will receive twice as many [stem cell] injections,” Johe says. They will get five more injections on the other side of the spinal cord compared with Cornicks’s surgery.

Cornick expects the researchers will follow his progress for a long time. He says he understands the need for people to be willing to participate in experimental research like this.

“For me it just seemed like the right thing to do. I almost felt I had an obligation to do this,” he says. “To help other people and myself.”

Source: Stem cell treatment goes from lab to operating room – CNN.com

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First U.S. stem cells transplanted into spinal cord | CNN.com

First U.S. stem cells transplanted into spinal cord (cnn.com)
For the first time in the United States, stem cells have been directly injected into the spinal cord of a patient, researchers announced Thursday.

A recent article announcing the first stem cells being transplanted into a human patient in the United States. I worked with the researchers and surgeon in this experiment and built the microinjectors that were used in the lead up experiments as well as for this first patient.

ATLANTA, Georgia (CNN) — For the first time in the United States, stem cells have been directly injected into the spinal cord of a patient, researchers announced Thursday.

Doctors injected stem cells from 8-week-old fetal tissue into the spine of a man in his early 60s who has advanced ALS, or amyotrophic lateral sclerosis. It was part of a clinical trial designed to determine whether it is safe to inject stem cells into the spinal cord and whether the cells themselves are safe.

ALS is a fatal neurodegenerative disease that causes the deterioration of specific nerve cells in the brain and spinal cord called motor neurons, which control muscle movement. About 30,000 Americans have ALS at any given time, according to the ALS Association.

There is no cure for ALS, which is better known as Lou Gehrig’sdisease, named after the New York Yankees’ first baseman and Hall of Famer who retired from baseball in the 1930s after being diagnosed with the disease.

As the illness progresses, patients lose their ability to walk, talk and breathe. Patients usually die within two to five years of diagnosis, according the ALS Association.

Neuralstem Inc., a Rockville, Maryland-based biotech company, received approval from the U.S. Food and Drug Administration to conduct the clinical trial in September. The company is fully funding the research and provides the stem cells that are being injected into the patients.

Neuralstem announced the start of the clinical trial in a news release Thursday.

Longtime ALS researcher and University of Michigan neurologist Dr. Eva Feldman is overseeing the first human clinical trial of a stem cell treatment in ALS patients.

“We are entering a new era of cell therapeutics for ALS, and in my opinion, it is an new era of hope for patients with ALS,” Feldman said.

At least 12 patients are expected to participate in this early research. They are to receive the stem cell transplants at Emory University in Atlanta, Georgia.

“This is the first study to see if the invasive injection into the spinal cord is safe for the patient,” said Lucie Bruijn, science director of the ALS Association.

This first patient in the clinical trial received several injections of stem cells into the lumbar region of the spinal cord, the area that controls leg function, because most ALS patients first lose muscle function in their legs, according to Karl Johe, Neuralstem’s chairman and chief scientific officer.

Bruijn says there have been a few other occasions outside the United States in which fetal stem cells have been injected into a patient, “but not necessarily using a very [rigorous] trial design.” She adds that there were also a couple of small studies in Italy that injected other types of stem cells into a few patients but that this is the first FDA-approved trial in the United States.

“Our biggest hope for stem cells is to significantly slow the progression the disease,” Bruijn said.

The ALS Association is not providing funding for this clinical trial, but it has supported the work of Dr. Nick Boulis, the Emory neurosurgeon who developed the surgical technique used to inject the stem cells.

Johe invented the technology that allows the company to manufacture billions of copies of stem cells that are taken from a single source of spinal cord cells: cells that were extracted from fetal tissue, which was donated to the company.

“The cells are human neural stem cells,” Johe said, acknowledging that the introduction of stem cells is a very invasive procedure.

“What we are attempting is a novel approach by directly injecting them into the middle of the spinal cord, which to our knowledge has never been done before,” Johe said.

Researchers plan to follow this and future patients participating in this trial for a long time to determine the safety of the procedure.

These particular stem cells — which came from the spinal cord of an 8-week-old fetus — are neural stem cells, which have the ability to turn into different types of nerve cells. These are not the same stem cells as the controversial human embryonic stem cells, which destroy the embryo when the stem cells are removed.

Johe says that once the safety of this type of transplant is determined, he and his colleagues hope to see whether this is a possible treatment for ALS.

“This is not a cure. We are not replacing those motor neurons [nerve cells which tell muscles to contract]. These stem cells don’t generate motor neurons. Instead they protect the still-functioning motor neurons,” Johe explained.

Bruijn says that injecting stem cells into the spinal cord — in the region where the motor neurons are located that affect ALS — is a breakthrough. But she cautions that this is only the first step in the first part of this clinical trial. It’s too early to draw any conclusions about the effectiveness of this treatment, especially since the trial has only just begun.

She notes that everyone involved with the study and other ALS patients have to wait and see what the results of the clinical trial will be.

The FDA granted the first approval for injecting human embryonic stem cells into humans to Menlo Park, California-based Geron Corporation in January 2009. Their trials were expected to start last summer but have yet to begin.

Source: First U.S. stem cells transplanted into spinal cord – CNN.com

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