I'm a biomedical and electrical engineer with interests in information theory, complexity, evolution, genetics, signal processing, IndieWeb, theoretical mathematics, and big history.
I'm also a talent manager-producer-publisher in the entertainment industry with expertise in representation, distribution, finance, production, content delivery, and new media.
Imagine having your back cut open, part of your spine removed, a stabilizing device that resembles a mini oil rig mounted on your back, the outer membrane of your spinal cord sliced open and experimental stem cells injected into it -- all for the advancement of science because it's not expected to benefit you.
Another article announcing the first stem cells being transplanted into a human patient in the United States. I worked with the researchers and surgeon in this experiment and built the microinjectors that were used in the lead up experiments as well as for this first patient.
For the first time in the United States, stem cells have been directly injected into the spinal cord of a patient, researchers announced Thursday.
A recent article announcing the first stem cells being transplanted into a human patient in the United States. I worked with the researchers and surgeon in this experiment and built the microinjectors that were used in the lead up experiments as well as for this first patient.
(hat tip to ZDNEt and Chris McEvoy for the lead)
From ZDNet:
“With no notice, Twitter yesterday “pulled the rug out from under its developers” one developer says, by discouraging auto-following and imposing 1,000 person-per-day following limits.”
Now… this is not news to me because of the “pulling the rug out from under its developers” thing or the 1,000 person-per-day following limit… The news to me as a Twitter user… I don’t really remember getting a message or alert that the new limits were going to be enacted. I use Twitter on a daily basis. It seems fairly odd that I would not know about the change.
I’m personally glad they’d be implementing something like this and wish they had done it about a month ago. Eventually without any controls the site would have become a waste land. In the spirit of using it as the tool it has become, they needed to implement changes like this as the site scaled up to more and more people. It’s very similar to the changes they instituted in the fall of 2008 when they created a cap of being able to follow more than 2000 people when your own number of followers wasn’t commensurate with that number. As a game theorist, I’m sure that people will somehow find some other way to artificially game the system.
As a separate note, who really wants to waste the time building thousands and thousands of followers when none of them are really going to ever pay attention to you? Yes, it’s great to have a high number, but really what is your ultimate reach? How many people are you engaging?
I had always wanted a nice McDowell & Craig vintage executive dual pedestal tanker desk, but the $2,000-$3,000 price tags for the ones in excellent condition or that had been refinished was way too steep for me. Some of the others I’ve seen for sale at lower prices were in mediocre shape and were in such ugly institutional colors, I couldn’t imagine having one at home.
Late last year, I found a couple from the 1950’s and 60’s that were in horrible physical shape that were going to be scrapped for their steel. I got both of them for $10 bucks and did some research on how to refurbish them myself.
I stripped off the corroded, stained, and torn linoleum off the tops, took them to a local place that does sandblasting to have them stripped and then sanded down the heavily rusting portions. (These desks are usually made of heavy 20 gauge solid steel, so they’re literally the “tanks” of office furniture.) Both were in relatively good condition structurally and didn’t have any significant body damage aside from some significant rust, so I decided not to bondo the couple of dings they had, which in the end I think just adds to their vintage beauty.
For the blue/gray one I found an industrial paint shop to do an old style enamel process. For the smaller red one, I sandblasted and painted/sealed the undercarriage and inside drawers and then used a special brushing process to obtain a nice brushed steel effect followed by a 5 layer clear coat seal to give it a high shine while still having the brushed steel visible through the clear coat.
Finally, I tried to find a place to recreate the original linoleum desktops, but there really isnt’ a supplier who does this and some of the alternatives were prohibitively expensive as was the process of redoing the metal trim to hold it on after the fact. I contemplated doing some various laminates and even formica, but ultimately decided that the bare metal top was too pretty to cover up. I finally gave a local glass shop a template for the top of the desk and had them cut out custom 1/4″ glass tops with rounded corners to match the desk shape and then bevel the edges slightly.
At long last they’re now both finished! They are truly beautiful and it’s nice having a desk about the size of a compact car and certainly as heavy! When I originally got the desks, Sonia refused to let me keep them they were in such terrible shape, and I spent a while convincing her to let me keep them. Once the first one was done she forbid me to “hide” it in our office and insisted that I put it in our living room because it was so pretty. I finally got the second one finished and gave it to her for her birthday in September.
It’s been an interesting enough process with such a beautiful end result, that I’m in the midst of acquiring a few additional desks including one that may be from the 30’s/40’s with some nice art deco design touches.
So I suppose I’m calling it my “hobby” at the moment.
Degradable quantum channels are among the only channels whose quantum and private classical capacities are known. As such, determining the structure of these channels is a pressing open question in quantum information theory. We give a comprehensive review of what is currently known about the structure of degradable quantum channels, including a number of new results as well as alternate proofs of some known results. In the case of qubits, we provide a complete characterization of all degradable channels with two dimensional output, give a new proof that a qubit channel with two Kraus operators is either degradable or anti-degradable, and present a complete description of anti-degradable unital qubit channels with a new proof. For higher output dimensions we explore the relationship between the output and environment dimensions (dB and dE, respectively) of degradable channels. For several broad classes of channels we show that they can be modeled with an environment that is “small” in the sense of ΦC. Such channels include all those with qubit or qutrit output, those that map some pure state to an output with full rank, and all those which can be represented using simultaneously diagonal Kraus operators, even in a non-orthogonal basis. Perhaps surprisingly, we also present examples of degradable channels with “large” environments, in the sense that the minimal dimension dE>dB. Indeed, one can have dE>14d2B. These examples can also be used to give a negative answer to the question of whether additivity of the coherent information is helpful for establishing additivity for the Holevo capacity of a pair of channels. In the case of channels with diagonal Kraus operators, we describe the subclasses that are complements of entanglement breaking channels. We also obtain a number of results for channels in the convex hull of conjugations with generalized Pauli matrices. However, a number of open questions remain about these channels and the more general case of random unitary channels.
Dates: September 13-14, 2008; 10am - 6pm, both days
Los Angeles Convention Center, 1201 South Figueroa Street Los Angeles, California 90015
Still FREE
Registration is Open until September 10th, 2008. Please visit our official site for more details and to sign up!
Microscopy, phenotyping and visual screens are frequently applied to model organisms in combination with genetics. Although widely used, these techniques for multicellular organisms have mostly remained manual and low-throughput. Here we report the complete automation of sample handling, high-resolution microscopy, phenotyping and sorting of Caenorhabditis elegans. The engineered microfluidic system, coupled with customized software, has enabled high-throughput, high-resolution microscopy and sorting with no human intervention and may be combined with any microscopy setup. The microchip is capable of robust local temperature control, self-regulated sample-loading and automatic sample-positioning, while the integrated software performs imaging and classification of worms based on morphological and intensity features. We demonstrate the ability to perform sensitive and quantitative screens based on cellular and subcellular phenotypes with over 95% accuracy per round and a rate of several hundred worms per hour. Screening time can be reduced by orders of magnitude; moreover, screening is completely automated.
Previously reported better fertilization rate after intracytoplasmic single sperm injection (ICSI) than after subzonal insemination of several spermatozoa was confirmed in a controlled comparison of the two procedures in 11 patients. Intracytoplasmic sperm injection was carried out in 150 consecutive treatment cycles of 150 infertile couples, who had failed to have fertilized oocytes after standard in-vitro fertilization (IVF) procedures or who were not accepted for IVF because not enough motile spermatozoa were present in the ejaculate. A single spermatozoon was injected into the ooplasm of 1409 metaphase II oocytes. Only 117 oocytes (8.3%) were damaged by the procedure and 830 oocytes (64.2% of the successfully injected oocytes) had two distinct pronuclei the morning after the injection procedure. The fertilization rate was not influenced by semen characteristics. After 24 h of further in-vitro culture, 71.2% of these oocytes developed into embryos, which were transferred or cryopreserved. Only 15 patients did not have embryos replaced. Three-quarters of the transfers were triple-embryo transfers. High pregnancy rates were noticed since 67 pregnancies were achieved, of which 53 were clinical, i.e. a total and clinical pregnancy rate of 44.7% and 35.3% per started cycle and 49.6% and 39.2% per embryo transfer. A total of 237 supernumerary embryos were cryopreserved in 71 treatment cycles.
Finished reading Induction and Intuition in Scientific Thought by P.B. Medawar
Originally published in 1969. This book explains what is wrong with the traditional methodology of “inductive” reasoning and shows that the alternative scheme of reasoning associated with Whewell, Pierce and Popper can give the scientist a useful insight into the way he thinks.
Advice for a Young Investigator
Santiago Ramón y Cajal
Biography & Autobiography
MIT Press
2004
book (paperback)
150
Library
This recently rediscovered classic, first published in 1897, is an anecdotal guide for the perplexed new scientific investigator as well as a refreshing resource for the old pro.
Written by Santiago Ramon y Cajal and translated by Larry W. Swanson and Neely Swanson.
This is certainly worth the read for the high qualities of its translation and vocabulary. There are lots of great aphorisms and brilliant bits of advice. Some of the parts about patriotism and information about things like picking a wife are anachronistically funny to read 100+ years after they were written.
In a talk aimed at the general public, Professor Hawking discusses theories on the origin of the universe. He explains how time can have a beginning, and addresses the progress made by cosmologists in an area which has traditionally belonged to theologists and philosophers.
Stephen Hawking holds the prestigious Lucasian chair at Cambridge University, once held by Sir Isaac Newton. He is one of the early developers of the theory of black holes and author of the international best-selling book A Brief History of Time.
PLEASE NOTE:This event is free, but tickets will be required. General admission tickets will be distributed on the morning of the lecture only. Please carefully review the complete ticketing procedures, available in a PDF file here.
Tuesday, April 4, 2006
8:00pm to 10:00pm
Beckman Auditorium
Arrived around 7:15 to get in line and ended up with a nice seat about 10 rows back from the stage. He was entertaining and even a tad inspirational, but it was definitely a “public” lecture and disappointingly had absolutely no technical content in the least.
Scientific knowledge grows at a phenomenal pace--but few books have had as lasting an impact or played as important a role in our modern world as The Mathematical Theory of Communication, published originally as a paper on communication theory in the Bell System Technical Journal more than fifty years ago. Republished in book form shortly thereafter, it has since gone through four hardcover and sixteen paperback printings. It is a revolutionary work, astounding in its foresight and contemporaneity. The University of Illinois Press is pleased and honored to issue this commemorative reprinting of a classic.
Christopher J. Aldrich, Engr ’96, of Los Angeles, writes:
“I recently booked Bea Arthur into two episodes of the TV show “Malcolm in the Middle,” for which she received an Emmy nomination. Following this, I left Creative Artists Agency to join David Entertainment, where I helped to produce MGM’s Breakers, starring Sigourney Weaver and Jennifer Love Hewitt. Now I’m preparing for production of Doctor Doolittle 2, starring Eddie Murphy and Behind Enemy Lines, with Gene Hackman and Owen Wilson.”
GOOD MORNING: Sunday morning, hours after they departed the SRO BevHilton ballroom where their Carousel of Hope Ball raised more than $6 million ($1.5 million from Marvin) benefiting the Children’s Diabetes Foundation, Marvin and Barbara Davis were hosting a lavish lunch for the out-of-town guests plus participants in the fundraiser. Marvin still couldn’t get over the ball’s finale when he saw wife Barbara on stage shaking it with Ricky Martin — who had the entire ballroom on its feet dancing. Barbara had also told Michael Jackson, “Ricky wants to meet you.” So Jackson and his date Elizabeth Taylor made their way backstage with Barbara, who shoved Michael onstage for a brief moment in the spotlight with the new king, Ricky Martin. Martin had flown in from Australia with his entire troupe to perform gratis, as did the other artists. I had been annoyed by Jackson and Taylor, who were sitting directly in front of our table. I thought them rude as they engaged in conversation during Ricky’s first two numbers. Jackson’s doctor, dermatologist Arnold Klein; had sidled up to talk with them during Martin’s performance. (Klein’s nurse Debbie Rowe, you recall, married/divorced Michael and bore him two children: son Prince, 3-1/2, and daughter Paris, 2-1/2). Jackson and his children have been regular (biweekly) visitors at the Davis’ home and the offspring get high marks from Marvin. John Davis had birthday-gifted dad Marvin with two tiny donkeys which graze on the lush lawn; the celeb lunch bunch had a full view of the tiny critters who have free rein (and you know what that includes) of the garden … At the BevHilton, Elizabeth and Michael were seated at one end of the head table on the first riser and in full view of the crowd below. As you might imagine, their presence created a major crush of visitors; some like Shirley MacLaine and Carrie Fisher (who just toiled with Taylor in “Those Old Broads”) carried on their conversation on the carpeting alongside Elizabeth. Another of the “Broads,” Joan Collins, was seated elsewhere with Evie and Leslie Bricusse. Collins is off to England to be at daughter Tara Newley’s side during her divorce battle. Joan is no stranger to that stage.
IT WAS NO SECRET that Ricky Martin, while the toast of the (young) world, was nervous about appearing before this mature, star-studded audience of performers and execs. He needn’t have been! Sure, he’s had movie offers but can’t accept because of the time they’d take away from his concerts and recordings. He winged out (in his plane) immediately after the BevHilton benefit to Miami … Performers at future BevHilton events will be pleased to know that Merv Griffin, the Carousel Ball’s host, has built a new backstage facility for talent. It was appreciated by the magnificent performers Toni Braxton (who said her mother has diabetes), young Charlotte Church (whatta voice!), David Foster and the musicians. Jay Leno’s takeoff tape on candidates Gore and Bush was classic, but his remarks about President Clinton are getting to be overdone by now. Touching moments were the remarks by Barbara Davis, daughter Dana (and the presentation of a hand receiving the brass ring sculpture) and Sidney Poitier. George Schlatter did a terrif job again producing the show … Clive Davis, one of the music chairmen, just signed Luther Vandross and O-Town to his new J Records and has now added a young duo from Brazil: Medeiros, brothers Julian and Rodalgo M. who sing in Portuguese, Spanish and English. Attending with Davis was his cousin Jo Schuman Silver, owner of SanFran’s fantastic “Beach Blanket Babylon” show, which continues SRO for every performance … Among those who stopped by to hug Michael Jackson was Berry Gordy, his discoverer. Also Suzanne De Passe. Also there Keely Shaye Smith and Pierce Brosnan, who told me he doesn’t expect to be away at work when their baby arrives in February. And they probably will not have the wedding until summer, in Ireland … As always, the Carousel Ball featured a silent auction which preceded in the BevHilton’s rooms surrounding the lobby and ballroom. Dana Davis and sister Nancy Davis-Rickel again chaired and the auction brought in $623,389 — to date. They are still selling items. Celebrity-designed plates brought in $56,700. Guests included Line Renaud, just in from Paris. She arrived with Veronique and Gregory Peck (he contributed one of the designed plates). Neil Diamond even bought a painting by LeRoy Neiman, which he had contributed … Marvin Davis, whose properties over the years have included 20th Century Fox and the Beverly Hills Hotel, has a new affiliation with Lend Lease with plans to build everything “all over the world.” Meanwhile the Davises continue to build to one day find a cure for childhood diabetes.
AND NOW, AS THEY SAY on the 11 o’clock news, “some late-breaking news”: Charlton Heston, who starred in the first two “Planet of the Apes” pix for 20th, will cameo in the next. Yes, he was killed off in the second pic — but now he returns as an ape. No, he’s not a foot soldier, so he won’t have to carry a gun — as I did, as an ape (member of the National Rhesus Assn., ya know) in the first “Planet” pic, opposite Heston. Producer Richard Zanuck and director Tim Burton launch next week in Paige, Ariz., site of the first.
It’s all about the donkeys:
John Davis had birthday-gifted dad Marvin with two tiny donkeys which graze on the lush lawn; the celeb lunch bunch had a full view of the tiny critters who have free rein (and you know what that includes) of the garden …
Army Archerd