I'm a biomedical and electrical engineer with interests in information theory, complexity, evolution, genetics, signal processing, IndieWeb, theoretical mathematics, and big history.
I'm also a talent manager-producer-publisher in the entertainment industry with expertise in representation, distribution, finance, production, content delivery, and new media.
Jacob gave a nice and humanizing presentation on some of the philosophy behind his startup. Though he didn’t get very deep into the topic indicated by the title of his talk, he was very engaging in exactly the manner you’d expect that a dude with a truck could be.
Pubmed Commons provides a forum, independent of a journal, where comments on articles in that journal can be posted. Why not air your displeasure there? The article is easily found (see PMID: 27467019) and, so far, there are no comments.
I’m hoping that one day (in the very near future) that scientific journals and other science communications on the web will support the W3C’s Webmention candidate specification so that when commentators [like Lior, in this case, above] post something about an article on their site, that the full comment is sent to the original article to appear there automatically. This means that one needn’t go to the site directly to comment (and if the comment isn’t approved, then at least it still lives somewhere searchable on the web).
Some journals already count tweets, and blog mentions (generally for PR reasons) but typically don’t allow access to finding them on the web to see if they indicate positive or negative sentiment or to further the scientific conversation.
I’ve also run into cases in which scientific journals who are “moderating” comments, won’t approve reasoned thought, but will simultaneously allow (pre-approved?) accounts to flame every comment that is approved [example on Sciencemag.org: http://boffosocko.com/2016/04/29/some-thoughts-on-academic-publishing/ — see also comments there], so having the original comment live elsewhere may be useful and/or necessary depending on whether the publisher is a good or bad actor, or potentially just lazy.
I’ve also seen people use commenting layers like hypothes.is or genius.com to add commentary directly on journals, but these layers are often hidden to most. The community certainly needs a more robust commenting interface. I would hope that a decentralized version using web standards like Webmentions might be a worthwhile and robust solution.
Fletch and the Widow Bradley
Fletch #4 (in the stories' chronological order: #3)
Gregory Mcdonald
Fiction; Mystery, Thriller & Suspense
Vintage Crime/Black Lizard
May 5, 2010
e-book
160
Overdrive
When Fletch finds a wallet with $25,000 in cash inside, he doesn’t realize it’s the last piece of good luck he’s going to see for a while. Because when he calls in to the News-Tribune, he discovers a story he’s written is causing quite a sensation, and not the good kind. He might just be out of a job permanently.
If Tom Bradley, the chairman of Wagnall-Phipps and one of Fletch’s principal sources, and not incidentally, the source of his paper’s embarrassment, is dead, who’s been signing his name to company documents, and why doesn’t the company treasurer seem to know? If he’s alive, how come his widow, Enid, has Tom’s ashes on the mantel?
Fletch may have more questions than answers on his hands, but he knows he’s a pretty good reporter, and if he’s going to get his reputation back, not to mention his job, he’s going to have to get to the bottom of more than one mystery.
This didn’t have as much of the biting humor as others in the Fletch canon or as much interesting character development or motivation. This was a bit more more up-the-middle in terms of plot, though the twist at the end was relatively well foreshadowed yet still surprising, particularly for the time frame in which it was written.
Fletch’s romantic interest Moxie was quirky, but didn’t do very much for the plot. His quest within the story was fairly straightforward, but wasn’t very well motivated from an internal perspective given his lackadaisical viewpoint in life and his general inability to afford his situation.
The finding of the $25,000 was an interesting opening, but sadly and quickly took a back seat in the plot. Given subsequent events, it could have played a better tangential role as a more integral B-plot. The final wrap up in the closing scenes was very unsatisfying for our viewpoint of Fletch as a hero and could have had a better twist. I’m getting the feeling that Mcdonald is still coming into his own at this point in his career and that the success of the 1984 film version of Fletch had a more significant influence on subsequent character development.
Most surprising was that the major plot twist occurred in a book in 1981, making it far more prescient of American culture to come in the new millennium. Barring the differences in the current state of journalism, this plot would still easily fit into the zeitgeist today from a cultural standpoint.
Given that the series is set in Los Angeles, I was curious to see if Tom Bradley, the dead character that motivates the plot, bore any resemblance to long time Los Angeles Mayor Tom Bradley. The real Bradley had been mayor for nearly 8 years (of an eventual 20 year reign) at the time the book was written, but I couldn’t discern any direct political satire in the naming of the character, though my knowledge of early 80’s Los Angeles politics is sketchy at best.
Last night we continued the blossoming group of indiewebbers meeting up on the East side of the Los Angeles Area, leading up to IndieWeb Camp Los Angeles in November.
The quiet writing hour started off quiet with Angelo holding down the fort while others were stuck in interminable traffic, but if the IRC channel is any indication, he got some productive work done.
Following introductions, I did a demo of the browser-based push notifications I enabled on this site about a week ago and discussed some pathways to help others explore options for doing so on theirs. Coincidentally, WordPress.com just unveiled some functionality like this yesterday that is more site-owner oriented than user oriented, so I’ll be looking into that functionality shortly.
Angelo showed off some impressive python code which he’s preparing to opensource, but just before the meeting had managed to completely bork his site, so everyone got a stunning example of a “502 Bad Gateway” notice.
At the break, we were so engaged we all completely forgot to either take a break or do the usual group photo. My 1 minute sketch gives a reasonable facsimile of what a photo would have looked like.
Peer-to-Peer Building and Help
With a new group, we spent some time discussing some general Indieweb principles, outlining ideas, and example projects.
Since Michael was very new to the group, we helped him install the WordPress IndieWeb plugin and configure a few of the sub-plugins to get him started. We discussed some basic next steps and pointers to the WordPress documentation to provide him some direction for building until we meet again.
We spent a few minutes discussing the upcoming IndieWebCamp logistics as well as outreach to the broader Los Angeles area community.
Next Meeting
For a new group, there’s enough enthusiasm to do at least two meetings a month, in keeping with the broader Homebrew movement, so we’re already committed to our next meeting on August 24. It’s tentatively at the same location unless a more suitable one comes along prior to then.
Thanks for coming everyone! We’ll see you next time.
I run across notices on the web like this regularly and it used to aggravate me to no end:
The dreaded “awaiting moderation” notice. Is my content lost forever or not?
Infuriatingly it usually involved having just spent 5 minutes reading something and then spending 10 minutes to hours writing a reasoned and thoughtful response. (Because every troll knows that’s what the internet was designed to encourage, right?)
After pressing the reply button (even scarier than hitting the “Publish” button because you don’t have the ability to edit it after-the-fact and someone else now “owns” your content), you see the dreaded notice that your comment is “AWAITING MODERATION…”
Will they approve it? Will they delete it? Is it gone forever? Did they really get it, or did it disappear into the ether? Oh #%@$!, I wish I’d made a back up copy because that took a bit of work, and I might like to refer to it again later. Are they going to censor my thoughts? Silence my voice?
I Get It: The Need for Moderation
I completely get the need for moderation on the web, particularly as almost no one is as kind, considerate, courteous, or civil as my friend P.M. Forni. (And who could be — he literally wrote the book(s) on the subject!)
On a daily basis, I’m spammed by sites desperate to sell or promote FIFA coins, Ray Bans, Christian Louboutin shoes, or even worse types of hateful blather, so I too gently moderate. I try to save my own readers from having to see such drivel, and don’t want to provide a platform or audience for them to shout from or at, respectively.
I won’t be silenced anymore
No longer can I be silenced by random moderators that I often don’t know.
Why, you ask?
I now post everything I write online onto a site I own first.
Because now, thanks to philosophies from the Indieweb movement and technologies like webmention, which growing numbers of websites are beginning to support, I now post everything I write online onto a site I own first. There it can be read in perpetuity by anyone who chooses to come read it, or from where I can syndicate it out to the myriad of social media sites for others to read en masse. (And maybe my voice has more reach than the site I’m posting to?)
Functionality like webmention (a more modern version of pingback or trackback) then allows my content to be sent to the website I was replying to in an elegant way for (eventual?) display. Or I can copy and paste it directly if they don’t support modern protocols.
Sure, they can choose to moderate me or choose not to feature my viewpoint on their own site if they wish, but at least I still own the work I put into those thoughts. I don’t have to worry about where they went or how I might be able to find them in the future. They will always be mine, and that is empowering.
Mike Morell, former deputy director of the CIA, on Donald Trump and his recent op-ed endorsing Hillary Clinton.
First let’s start with the fact that I’m a big Mike Morell fan! If you want to know about world politics and know more about not only the big picture but the minutiae, and learn it from someone who can not only lay out an argument succinctly but with great depth, there is no better tutor than Morell. A former deputy director and a former acting director of the CIA, Mike Morell is about as good as it gets in understanding foreign policy. Morell is great at laying out simple facts and figures relating to incredibly complex and nuanced events and exploring a range of potential options, and then, only if asked, will provide any personal opinion on a subject. I love the fact that he appears frequently on Charlie Rose which is about as good as it gets in the interview game. Listening to their discussions will make you a better citizen, not only of America, but of the world.
Last week I was floored that Morell, a lifelong non-partisan due in great part to his decades long government service, broke ranks to endorse Hillary Clinton in an influential op-ed piece in the New York Times. I suspect (completely a gut reaction on my part) that despite not having registered with a political party, Morell leans more to the right and would generally vote Republican. Despite this, he laid out a scathing argument why Donald Trump should not be the next president. He was my foreign policy hero to begin with, but now I’ve got to build the pedestal even higher. I’m glad that despite the sacrifices he had to make to present such an argument, that he stood up firmly for what he believes is right for the country.
If you haven’t read his piece from Friday, I highly recommend it. If you prefer a video version with more discussion and elaboration, then last night’s Charlie Rose was fantastic.
Analysis of phase 1 and 2 trials testing the safety of spinal cord transplantation of human stem cells in patients with amyotrophic lateral sclerosis (ALS) with escalating doses and expansion of the trial to multiple clinical centers.
I built the microinjectors used in these experiments for injecting stem cells into the first human patients.
Transplantation of spinal cord–derived neural stem cells for ALS
Analysis of phase 1 and 2 trials
Authors: Jonathan D. Glass, MD; Vicki S. Hertzberg, PhD; Nicholas M. Boulis, MD; Jonathan Riley, MD; Thais Federici, PhD; Meraida Polak, RN; Jane Bordeau, RN; Christina Fournier, MD; Karl Johe, PhD; Tom Hazel, PhD; Merit Cudkowicz, MD; Nazem Atassi, MD; Lawrence F. Borges, MD; Seward B. Rutkove, MD; Jayna Duell, RN; Parag G. Patil, MD; Stephen A. Goutman, MD; Eva L. Feldman, MD, PhD
ABSTRACT
Objective: To test the safety of spinal cord transplantation of human stem cells in patients with amyotrophic lateral sclerosis (ALS) with escalating doses and expansion of the trial to multiple clinical centers.
Methods: This open-label trial included 15 participants at 3 academic centers divided into 5 treatment groups receiving increasing doses of stem cells by increasing numbers of cells/injection and increasing numbers of injections. All participants received bilateral injections into the cervical spinal cord (C3-C5). The final group received injections into both the lumbar (L2-L4) and cervical cord through 2 separate surgical procedures. Participants were assessed for adverse events and progression of disease, as measured by the ALS Functional Rating Scale–Revised, forced vital capacity, and quantitative measures of strength. Statistical analysis focused on the slopes of decline of these phase 2 trial participants alone or in combination with the phase 1 participants (previously reported), comparing these groups to 3 separate historical control groups.
Results: Adverse events were mostly related to transient pain associated with surgery and to side effects of immunosuppressant medications. There was one incident of acute postoperative deterioration in neurologic function and another incident of a central pain syndrome. We could not discern differences in surgical outcomes between surgeons. Comparisons of the slopes of decline with the 3 separate historical control groups showed no differences in mean rates of progression.
Conclusions: Intraspinal transplantation of human spinal cord–derived neural stem cells can be safely accomplished at high doses, including successive lumbar and cervical procedures. The procedure can be expanded safely to multiple surgical centers.
Classification of evidence: This study provides Class IV evidence that for patients with ALS, spinal cord transplantation of human stem cells can be safely accomplished and does not accelerate the progression of the disease. This study lacks the precision to exclude important benefit or safety issues.
ReadFletch Won by Gregory Mcdonald(Vintage Crime/Black Lizard)
Fletch Won
Fletch #8 (in the stories' chronological order: #1)
Gregory Mcdonald
Fiction; Mystery, Thriller & Suspense
Vintage Crime/Black Lizard
April 7, 2010
e-book
272
Overdrive
As a fledgling reporter, Fletch is doing more flailing than anything else. That and floating around from department to department trying to figure where he fits in. His managing editor’s got him pegged for the society pages, but the kind of society Fletch gets involved with is anything but polite. His first big interview, a millionaire lawyer with a crooked streak and an itch to give away some of his ill-gotten gains, ends up dead in the News-Tribune’s parking lot before Fletch can ask question number one. So Fletch ends up going after the murderer instead, and ends up learning a thing or two about crime and punishment. At the same time, he’s supposed to be covering (or maybe uncovering) a health spa that caters to all its clients' needs, and gets hired as a very personal trainer. Never mind that he’s supposed to be getting married at the end of the week; Fletch has a few other engagements to take care of first.
I don’t remember the original Fletch (book) having the awesome biting, wry humor I found in this which is more reminiscent of the adapted feature film version. But it’s a hilarious little romp of entertainment. While not as tightly crafted in terms of plot as I remember the introductory book, which I read more than 25 years ago, it was terrifically enjoyable from start to finish.
The Rio Olympics reminded me that I’d gotten Carioca Fletch to read back in the late 80’s and never got around to it, so I thought I’d come back and revisit the series. This certainly didn’t disappoint, so I’ll be delving back through the rest to fill in some entertainment in the late end of the summer. Since I couldn’t get my hands on the second in the series from a publishing chronology, I thought I’d read them in the series timeline order instead. (Or as closely as I can from the perspective of obtaining them in this order.)
I read an e-book version of the text which was fair obviously an OCR’ed version of an earlier paperback version. There were a handful of egregious spelling errors and typos that should have been fixed, but fortunately the quality wasn’t too horrific. Hopefully the quality of OCR is maintained or improved throughout the remainder of the series.
Anand Sarwate (Twitter)
Lior Pachter (& Comments by Donald Forsdyke) (Bits of DNA)
Fletch and the Widow Bradley
